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- Volume 14, Issue 10, 2008
Current Pharmaceutical Design - Volume 14, Issue 10, 2008
Volume 14, Issue 10, 2008
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Editorial [ Advanced Glycation End Products (AGEs) and their Receptor (RAGE) in Health and Disease Executive Editor: Sho-ichi Yamagishi ]
More LessThere is a growing body of evidence to show that AGEs, which form and accumulate at an accelerated rate under diabetes and normal aging, are implicated in the pathogenesis of various devastating disorders such as diabetic vascular complications, coronary heart diseases, Alzheimer's disease, cancer growth and metastasis, insulin resistance and nonalcoholic fatty liver disease. In addition, the engagement of the recept Read More
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AGE-RAGE System and Carcinogenesis
Authors: Riichiro Abe and Sho-ichi YamagishiRecent clinical studies have reported an increased risk for various types of cancers in patients with diabetes. Diabetes is characterized by increased oxidative stress conditions. Hyperglycemia induces oxidative stress generation in a variety of cells via various metabolic pathways, thus causing oxidative DNA damage, an initial step of carcinogenesis. There is accumulating evidence that advanced glycation end products (AGE), se Read More
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Role of AGEs in Diabetic Nephropathy
Authors: Kei Fukami, Sho-ichi Yamagishi, Seiji Ueda and Seiya OkudaDiabetic nephropathy is the most common cause of end-stage renal disease in the world, and accounts for a significant increase in morbidity and mortality in patients with diabetes. Therapeutic options such as strict blood pressure and/or glycemic control are effective for preventing the development and progression of diabetic nephropathy, but the number of diabetic patients on hemodialysis is still increasing. Therefore, Read More
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Role of Advanced Glycation End Products in Diabetic Neuropathy
Authors: Kazuhiro Sugimoto, Minoru Yasujima and Soroku YagihashiDiabetic neuropathy is the commonest form of peripheral neuropathy in the developed countries of the world. In diabetic patients, the presence of peripheral neuropathy increases their risks for developing foot ulceration and subsequent necrosis that necessitates lower limb amputation. Although the precise mechanisms underlying diabetic neuropathy remain unclear, there is evidence that hyperglycemia- induced format Read More
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Role of Advanced Glycation End Products (AGEs) and Oxidative Stress in Diabetic Retinopathy
Authors: Sho-ichi Yamagishi, Seiji Ueda, Takanori Matsui, Kazuo Nakamura and Seiya OkudaDiabetic retinopathy is a common and potentially devastating microvascular complication in diabetes and is a leading cause of acquired blindness among the people of occupational age. However, current therapeutic options for the treatment of sight-threatening proliferative diabetic retinopathy such as photocoagulation and vitrectomy are limited by considerable side effects and far from satisfactory. Therefore, to de Read More
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Advanced Glycation End Products (AGEs) and their Involvement in Liver Disease
Authors: Hideyuki Hyogo and Sho-ichi YamagishiAdvanced glycation end products (AGEs) are a heterogeneous group of molecules, formed in vivo both by non-oxidative and oxidative reactions of sugars and their adducts to proteins and lipids. It is now well established that formation and accumulation of AGEs progress during normal aging, and at an extremely accelerated rate under diabetes, thus being implicated in various types of AGEs-related disorders such as diabetic v Read More
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Possible Involvement of Advanced Glycation End-Products (AGEs) in the Pathogenesis of Alzheimer's Disease
Authors: Masayoshi Takeuchi and Sho-ichi YamagishiAlzheimer's disease (AD) is the most common cause of dementia in developed countries. AD is characterized pathologically by the presence of senile plaques (SPs) and neurofibrillary tangles (NFTs), the major constituents of which are amyloid β protein and tau protein, respectively. Advanced glycation end-products (AGEs), senescent macroprotein derivatives formed at an accelerated rate under normal aging, can b Read More
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The Role of AGEs in Cardiovascular Disease
Authors: Karin Jandeleit-Dahm and Mark E. CooperAdvanced glycation end-products (AGEs) are generated in the diabetic milieu, as a result of chronic hyperglycemia and enhanced oxidative stress. These AGEs, via direct and receptor dependent pathways promote the development and progression of cardiovascular disease. AGEs accumulate at many sites of the body including the heart and large blood vessels in diabetes. These modified proteins interact with receptors such a Read More
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Advanced Glycation End Products and Insulin Resistance
Authors: Hiroyuki Unoki and Sho-ichi YamagishiNon-enzymatic modification of proteins by reducing sugars, a process that is also known as Maillard reaction, leads to the formation of advanced glycation end products (AGEs) in vivo. There is a growing body of evidence that formation and accumulation of AGEs progress during normal aging, and at an extremely accelerated rate under diabetes, thus being involved in the pathogenesis of diabetic vascular complications. Furthe Read More
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Potential Strategies for Minimizing Mechanism-Based Inhibition of Cytochrome P450 3A4
More LessCytochrome P450 (CYP) 3A4, one of the most abundant hepatic Phase I enzymes, is able to metabolize more than 50% currently available therapeutic drugs. However, this enzyme is subject to mechanism-based inhibition by a number of xenobiotics and commonly- used drugs, which is characterized by NADPH-, time- and concentration-dependent enzyme inactivation, occurring when the parental drugs are converted by Read More
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Recent Developments in the Chemistry and in the Biological Applications of Amidoximes
Amidoximes are compounds bearing both a hydroxyimino and an amino group at the same carbon atom which makes them versatile building blocks for the synthesis of various heterocycles. Their importance in chemistry along with their rich biology, make amidoximes an attractive target for medicinal chemists, biochemists and biologists. Amidoximes and simple O-substituted derivatives possess very important biological a Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
- Issue 36
- Issue 35
- Issue 34
- Issue 33
- Issue 32
- Issue 31
- Issue 30
- Issue 29
- Issue 28
- Issue 27
- Issue 26
- Issue 25
- Issue 24
- Issue 23
- Issue 22
- Issue 21
- Issue 20
- Issue 19
- Issue 18
- Issue 17
- Issue 16
- Issue 15
- Issue 14
- Issue 13
- Issue 12
- Issue 11
- Issue 10
- Issue 9
- Issue 8
- Issue 7
- Issue 6
- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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