- Home
- A-Z Publications
- Current Pharmaceutical Design
- Previous Issues
- Volume 14, Issue 18, 2008
Current Pharmaceutical Design - Volume 14, Issue 18, 2008
Volume 14, Issue 18, 2008
-
-
Editorial [ Hot Topic: Modifying Cardiovascular Risk Factors: Novel Cardiovascular Targets for Treatment by Noninvasive Imaging Techniques (Executive Editors: Aurelio Leone and Luigi Landini) ]
Authors: Luigi Landini and Aurelio LeoneCardiovascular risk factors, whatever they may be approached to be studied - and there are a lot of approaches: clinical, biological, metabolic, epidemiologic, statistic and diagnostic - lead all to a proven result that is increasing the incidence of cardiovascular pathology. The early and careful assessment of cardiovascular risk factors as well as their influence on functional and metabolic steps of the heart permit to establish tho Read More
-
-
-
Fundamentals in Cardiovascular Imaging Technologies
Authors: L. Landini, M. F. Santarelli, L. L. Jr. and V. PositanoThe aim of this paper is to introduce the prominent in vivo cardiovascular imaging modalities such as magnetic resonance imaging, nuclear imaging and ultrasound from both the physical and molecular imaging perspectives. A brief introduction to the molecular imaging principles is also reported. Special emphasis will be given to the imaging parameters of sensitivity and spatial resolution, and the trade-off between spati Read More
-
-
-
Morphology of Atherosclerotic Plaque: Its Feature by Imaging Study
Authors: Gabriella Passacquale, Claudio Ferri, Sergio Tiberti and Giovambattista DesideriAtherosclerotic plaque plays a crucial role for the development of ischaemic diseases and, therefore, its early diagnosis and feature can help to reduce the incidence of cardiovascular events. Detection of early atherogenesis and characterization of plaque feature are the major end-points of research in cardiovascular imaging. Different techniques have been proposed as instrument for morphological and functional study of v Read More
-
-
-
Endothelial Function Assessment in Complicated Hypertension
Authors: A. Virdis, L. Ghiadoni, D. Versari, C. Giannarelli, A. Salvetti and S. TaddeiA large body of evidence indicates that patients with essential hypertension, and even more those with complicated hypertension, are characterized by endothelial dysfunction characterized by impaired NO availability secondary to oxidative stress production. A dysfunctioning endothelium is an early marker of the development of atherosclerotic changes and can also contribute to cardiovascular events. Vascul Read More
-
-
-
Smoking and Cardiovascular System: Cellular Features of the Damage
Authors: A. Leone, L. L. Jr., O. Biadi and A. BalbariniTwo morphological features may be seen as a main result of the cardiovascular cell damage caused by cigarette smoking: myocardial cell necrosis and smoke cardiomyopathy that, however, can lead to cell necrosis in case of chronic prolonged exposure to tobacco smoke. Both these pathological patterns recognise hypoxia as the basic mechanism. Cardiovascular cell damage may involve either myocardial cell or coro Read More
-
-
-
Coronary Magnetic Resonance Imaging
Authors: Sebastian Kelle, Robert G. Weiss and Matthias StuberCoronary magnetic resonance imaging is a powerful non-invasive technique for the combined assessment of coronary artery anatomy and function. In the present review article, challenges in coronary artery imaging are discussed and results obtained in both healthy volunteers and patients with cardiovascular disease are presented. This includes a short overview of coronary artery vessel lumen and wall imaging, co Read More
-
-
-
The Application of NMR Spectroscopy for the Study of Heart Failure
Authors: Michiel t. Hove and Stefan NeubauerMagnetic resonance spectroscopy (MRS) has been used for several decades to examine the biochemistry of the myocardium in a non destructive manner. 31P MRS, in particular, has been used to study heart failure. 31P MRS allows for the detection of adenosine triphosphate (ATP), the primary energy source for all energy consuming processes in cardiomyocytes, and phosphocreatine (PCr). Via the creatine kinase (CK) r Read More
-
-
-
Radionuclide PET and PET/CT in Coronary Artery Disease
Authors: D. Neglia, O. Rimoldi, P. A. Kaufmann and P. G. CamiciIn the present review, the basis of non invasive assessment of CAD, the most recent technical developments and results obtained by PET in cardiovascular research and clinical cardiology are described. PET has provided a wealth of new information in the field of cardiac pathophysiology and remains the gold standard for non-invasive measurements of MBF and CFR against which new techniques should be tested. The pos Read More
-
-
-
Role of the Autonomic Nervous System and Neuropeptides in the Development of Obesity in Humans: Targets for Therapy?
Authors: Jerry R. Greenfield and Lesley V. CampbellObesity and type 2 diabetes have reached epidemic proportions worldwide. These metabolic disorders, particularly obesity, are characterised by increased basal sympathetic nervous system (SNS) activity but an impaired sympathetic response to certain stimuli, such as insulin. Although targeting the SNS may seem an attractive avenue for the pharmacological prevention and treatment of obesity and related metabolic di Read More
-
-
-
Engineering Silica Particles as Oral Drug Delivery Vehicles
Authors: S. P. Rigby, M. Fairhead and C. F. van der WallePorous silica particles are emerging as complementary systems to polyester microspheres for the encapsulation and controlled delivery of small-organic drugs. Their recent application in pharmaceutics is strengthened by well-established characterization and synthetic routes from the chemical engineering sciences. Silica is an interesting scaffold material for the encapsulation of organic molecules. It can be formed into Read More
-
Volumes & issues
-
Volume 31 (2025)
-
Volume 30 (2024)
-
Volume 29 (2023)
-
Volume 28 (2022)
-
Volume 27 (2021)
-
Volume 26 (2020)
-
Volume 25 (2019)
-
Volume 24 (2018)
-
Volume 23 (2017)
-
Volume 22 (2016)
-
Volume 21 (2015)
-
Volume 20 (2014)
-
Volume 19 (2013)
-
Volume 18 (2012)
-
Volume 17 (2011)
-
Volume 16 (2010)
-
Volume 15 (2009)
-
Volume 14 (2008)
- Issue 36
- Issue 35
- Issue 34
- Issue 33
- Issue 32
- Issue 31
- Issue 30
- Issue 29
- Issue 28
- Issue 27
- Issue 26
- Issue 25
- Issue 24
- Issue 23
- Issue 22
- Issue 21
- Issue 20
- Issue 19
- Issue 18
- Issue 17
- Issue 16
- Issue 15
- Issue 14
- Issue 13
- Issue 12
- Issue 11
- Issue 10
- Issue 9
- Issue 8
- Issue 7
- Issue 6
- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
-
Volume 13 (2007)
-
Volume 12 (2006)
-
Volume 11 (2005)
-
Volume 10 (2004)
-
Volume 9 (2003)
-
Volume 8 (2002)
-
Volume 7 (2001)
-
Volume 6 (2000)
Most Read This Month
Article
content/journals/cpd
Journal
10
5
false
en
