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- Volume 14, Issue 31, 2008
Current Pharmaceutical Design - Volume 14, Issue 31, 2008
Volume 14, Issue 31, 2008
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Editorial [Hot Topic: PET and SPECT in Drug Evaluation and Drug Design Imaging Inflammatory Processes, Tumors, and the Endocannabinoid System(Executive Editor: Aren van Waarde)]
More LessThis is the fifth issue of Current Pharmaceutical Design discussing applications of PET and SPECT in drug development. The initial issue (Vol.6, No.16, 2000) described methods for measuring the deposition, biodistribution and pharmacokinetics of drugs including their interactions with specific targets. The second issue (Vol.8, No.16, 2002) focused on the interface between nuclear medicine and molecular biology. A third Read More
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PET Imaging of the Peripheral Benzodiazepine Receptor: Monitoring Disease Progression and Therapy Response in Neurodegenerative Disorders
Authors: Janine Doorduin, Erik F.J. de Vries, Rudi A. Dierckx and Hans C. KleinIt is important to gain more insight into neurodegenerative diseases, because these debilitating diseases can not be cured. A common characteristic of many neurological diseases is neuroinflammation, which is accompanied by the presence of activated microglia cells. In activated microglia cells, an increase in the expression of peripheral benzodiazepine receptors (PBR) can be found. The PBR was suggested as a t Read More
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Receptor Binding Ligands to Image Infection
Authors: M. Chianelli, O. C. Boerman, G. Malviya, F. Galli, W. J.G. Oyen and A. SignoreThe current gold standard for imaging infection is radiolabeled white blood cells. For reasons of safety, simplicity and cost, it would be desirable to have a receptor-specific ligand that could be used for imaging infection and that would allow a differential diagnosis between sterile and septic inflammatory processes. Ligands tested for this purpose include labeled peptides (99mTc-labeled f-Met-Leu-Phe, 123I-IL-1ra, 99mTc-IL-8, Read More
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Proliferation Markers for the Differential Diagnosis of Tumor and Inflammation
Authors: Aren v. Waarde and Philip H. ElsingaFDG, the most common radiopharmaceutical for PET imaging in oncology, is not tumor-specific. Significant tracer accumulation can also occur in viral, bacterial and fungal infections, in other forms of inflammatory tissue and in brown fat. FDG accumulation in inflammatory tissue may cause false positives during cancer screening and false classification as a nonresponder during drug treatment. Yet, discrimination between be Read More
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Growth Factor/Peptide Receptor Imaging for the Development of Targeted Therapy in Oncology
Receptor imaging by means of positron emission tomography (PET) and single photon emission computerized tomography (SPECT) may non-invasively address questions that are essential to the development and the clinical application of drugs targeting receptors expressed on human malignancies : is the receptor targeting drug getting to the tumor in the required concentration, is there a heterogeneity in tumor uptak Read More
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Immunoscintigraphy as Potential Tool in the Clinical Evaluation of HER2/neu Targeted Therapy
Many new targeted anticancer drugs have been developed. In order for these drugs to be effective, the tumor target has to be present during treatment. Currently there are only a few biomarkers available to help the physician select the appropriate targeted drug for the patient and often tumor tissue is required for biomarker assays. Immunoscintigraphy might be able to improve diagnostic imaging, to guide antibody base Read More
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Development of Radioligands for In Vivo Imaging of Type 1 Cannabinoid Receptors (CB1) in Human Brain
Authors: Andrew G. Horti and Koen V. LaereCerebral cannabinoid receptor (CB1) and cannabinoid drugs constitute a vibrant field in modern medicine and pharmacology. However, the physiological and pharmacological roles played by the cannabinoid receptor in the central nervous system are still not fully understood. Positron-emission tomography (PET) is the most advanced technique for non-invasive research of cerebral receptors. Quantitative PET imaging o Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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- Issue 1
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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