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Volume 20, Issue 7
  • ISSN: 1573-4129
  • E-ISSN: 1875-676X
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Abstract

Background

Bge. is a plant extensively utilized in Traditional Chinese Medicine (TCMs). Nevertheless, our knowledge of the chemical components and metabolic complexities in its extracts is still quite limited.

Objective

The study aimed to thoroughly analyze the flavonoid metabolism in Bge. extracts and conduct a pharmacodynamic evaluation.

Methods

In this study, we investigated the metabolism of flavonoids in Bge. extracts using SD rats. The research adopted the strategy of “i metabolism assessment, basic study of pharmacodynamics and preliminary evaluation of molecular docking” to systematically investigate the pharmacodynamic substances and targets of action of Bge.

Results

The results of the study showed that the main metabolic forms of Bge. include hydroxylation, methylation, and glycosylation. Among them, luteolin in the total flavonoids of Bge. has the strongest antimicrobial and antioxidant ability. Outcomes of molecular docking experiments indicated that the glycosylated metabolite of luteolin had a significant advantage in acting with Glp-1 (Glucagon-like peptide-1).

Conclusion

The present study revealed the metabolic pathways of total flavonoids in Bge. It not only effectively screened out their pharmacodynamic substances and targets but also provided a theoretical basis for the application of TCMs into a systematic application and also provided ideas for the direction of drug optimization in the future. However, the sample range of this study is limited, and it generalizability needs to be investigated.

© 2024 Bentham Science Publishers
© 2024 The Author(s). Published by Bentham Science Publishers. This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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Analyzing the Metabolic Destiny of Potentilla discolor Bge. Extract and its Primary Components in Rat Models
Current Pharmaceutical Analysis 20, 524 (2024); https://doi.org/10.2174/0115734129298520240812062841
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Supplementary material is available on the publisher’s website along with the published article.

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  • Article Type:     Research Article
Keyword(s): glycosides, metabolite, molecular docking, pharmacodynamic; Potentilla discolor bge., flavonoids

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