Current Pharmaceutical Analysis - Volume 17, Issue 6, 2021

Aim/Background: In this study, a stability-indicating method of the anticancer agent cabazitaxel was developed and validated. This method will be used to determine the chemical stability of commercially available concentrate-solvent mixture cabazitaxel (Jevtana®) to examine the possibility of multi-dosing from the same product vial after storage. The impossibility to re-use leftovers today is contributing to unnecessary and sign Read More

Background: Xuezhikang capsule, which contains cholesterol synthase inhibitors and a large number of natural statins, is put in the clinical application of lipid-lowering and so on. However, the specific use of dose, lipid-lowering effect and the relationship between metabolites are to be further studied. Introduction: Metabonomics is the study of the relationship between the change of quantity and physiological changes fr Read More

Background: Fu Zheng Fang (FZF) is an important Chinese medicine prescription for tumor treatment in hospitals, which has two different types, traditional Chinese medicine (TCM) decoction pieces and TCM formula granules. Objective: This study aimed to determine the effective composition of the drug FZF. Methods: In this research, FZF decoction pieces and FZF formula granules were collected and their composition, determ Read More

Background: To control the potential presence of heavy metals in pharmaceuticals, the United States Pharmacopeia (USP) and International Conference on Harmonization (ICH) have put forth new requirements and guidelines. USP <232> and ICH Q3D specify 24 elemental impurities and their concentration limits in consideration of the permitted daily exposure (PDE) of different drug categories (oral, parenteral and inhalat Read More

Background: Pedunculoside (PE) is a triterpene saponin from the barks of Ilex rotunda, a Traditional Chinese Medicine called Jiubiying, which is used for the treatment of cold and fever, tonsillitis, sore throat, acute and chronic hepatitis. Previous studies have confirmed that crude extract orally has a significant therapeutic effect on myocardial infarction. Methods: A simple, sensitive, and specific method by using UPLC-MS/MS to Read More

Background: Prodrugs principle is widely used to improve the pharmacological and pharmacokinetic properties of some active drugs. Much effort was made to develop metronidazole prodrugs to enhance antibacterial activity and/or to improve pharmacokinetic properties of the molecule or to lower the adverse effects of metronidazole. Objective: In this work, the pharmacokinetic properties of some of monoterpenes and euge Read More

Background: Apranax Plus® is a new bilayer tablet dosage form, which combines two active pharmaceutical ingredients: naproxen sodium and codeine phosphate. Objective: The purpose of this work was to develop an Ultra-High-Performance Liquid Chromatography (UHPLC) method for the separation and determination of codeine phosphate hemihydrate impurities in a bilayer tablet dosage form. Methods: The separation an Read More

Background: Currently, ovulation stimulation with clomiphene citrate is the most commonly used treatment for infertility. It stimulates the secretion of gonadotropins necessary for the release of an egg. Objective: In this study, microextraction method of liquid phase was utilized using hollow fiber with high-performance liquid chromatography and ultraviolet (HPLC-UV) detector for pre-concentration and measuring clomiphene citra Read More

Background: The illegal virtual market for food supplements facilitates fraud and adulteration. Worldwide concern for consumer safety is growing on the part regulatory agencies, healthcare professionals and consumers. Objective: This work aimed to evaluate the presence of sexual stimulants and anabolic steroids commonly used in the adulteration of dietary supplements through the development of a high performance liquid Read More

Objective: A particular, easy, and precise reverse phase liquid chromatographic technique was developed for the determination of Zaltoprofen in human plasma. Methods: The ODS C18 (250mm x 4.6mm, 5μm) column was utilized for determination. The mobile phase contains buffer and acetonitrile (55:45 v/v). The rate of flow was 1.0 ml/min. The volume of infused sample was 10 μl. The column was kept at a temperatur Read More

Background: A simple and sensitive quantitation analytical technique by liquid chromatography– tandem mass spectrometry (LC-MS/MS) is essential for fedratinib in biological media with kinetic study in healthy rabbits. Objective: The main objectives of the present research work are the development of the LC-MS/MS method and to validate a procedure for the quantitation of fedratinib and its application to kinetic study in Read More

Background: A tablet dosage form widely used in the treatment of cough and cold, containing phenylephrine hydrochloride, paracetamol, caffeine, and diphenhydramine hydrochloride as active pharmaceutical ingredient was selected for the development of a novel, rapid, simultaneous isocratic reversed phase-high performance liquid chromatography (RP-HPLC) method. Objective: The objective of this paper was to develop and Read More

Background: Acefylline (Acef) is a derivative of theophylline that has bronchodilator effects. Two binary mixtures were marketed for Acef: Acefylline piperazine/ Phenobarbitone (Acef- P/Phen) and Acefylline heptaminol/ Cinnarizine (Acef-H/ Cinn). To our knowledge, none of the reported methods had the capacity to determine Acef in its binary mixture in the presence of its degradation products and potential impurity theophylline ( Read More

Purpose: Hydrazones are a class of azomethines with a wide spectrum of pharmacological properties that are influenced by the pH of the media. The purpose of this study was to investigate acidbase properties of five 4-nitrobenzaldehyde-4-substitutedphenyl-1-carbonylhydrazones in sodium hydroxide media (14>pH>7). Methods: The dissociation process was followed by UV-Vis spectroscopy, in ethanol-water (V/V, 1:1) solutio Read More

Introduction: Clarithromycin is a macrolide antibiotic that is active against a variety of microorganisms. It is widely used in the local and international market in different pharmaceutical dosage forms. However, its chemical structure lacks a chromophore and hence it has a low absorption and this makes it more difficult to be detected at low concentrations. In this research project, we proposed an easy and feasi Read More