Current Pharmaceutical Analysis - Volume 17, Issue 2, 2021

This paper includes different analytical methods available for the estimation of the Perindopril Erbumine. Perindopril Erbumine is an Angiotensin-Converting Enzyme (ACE) inhibitor used to treat hypertension and heart failure. The drug is officially listed in the monograph of USP, BP & EP. This drug is available in various marketed formulations. There are so many methods reported for the estimation of Perindopril Erbumine and Read More

Introduction: Scutellaria Baicalensis Georgi (SBG), a Traditional Chinese Medicine (TCM) used for the treatment of antiviral therapy, contains many flavonoids. Materials and Methods: A simple, fast and accurate 1H quantitative nuclear magnetic resonance (1HqNMR) method was established for simultaneously determination of four flavonoids (Baicalin, Baicalein, Wogonin and Wogonoside) in SBG extract by using 3,4,5-trichloropyr Read More

Background: Formaldehyde is a key intermediate/reagent in the synthesis of many significant pharmaceutical compounds. It is genotoxic as it interacts with the DNA, RNA and hence there is a pressing need to develop sensitive analytical methods for its trace level determination. Objective: The present study aims to develop a simple and robust Ultra-High-Performance Liquid Chromatographic (UHPLC) method for the trace l Read More

Background: ZT55 is a novel natural product isolated from Radix isatidis. It is a highlyselective tyrosine kinase inhibitor against myeloproliferative neoplasms. Although earlier research has described the pharmacodynamic properties of ZT55 in vivo and in vitro, the quantitative determination and pharmacokinetic profile in vivo have not been thoroughly studied. Methods: A novel liquid chromatography-tandem mass spectrom Read More

Background: A normal phase- High Performance Liquid Chromatographic (HPLC) method was developed for the enantioseparation of Oxomemazine. Methods: Separation of enantiomers was attained on Amylose Tris (5-chloro-2-methylphenylcarbamate) using n-hexane: Iso-propyl Alcohol (IPA): Diethylamine (DEA) (60: 40: 0.1) as the mobile phase and the peaks were observed at 227nm using PDA detector. The run Read More

Background: Linagliptin (LNG) is an oral hypoglycemic agent that acts by inhibiting the enzyme dipeptidyl peptidase - 4 (DPP-4) and reduces blood sugar levels in type-II diabetic patients. To date, the literature presents few analytical methods for the determination of LNG. However, no reversed phase-high performance liquid chromatography (RP-HPLC) method has been reported for the determination of LNG in nanotransfersom Read More

Background: Current guidelines for the treatment of hypertension recommend combination therapy, which intends to control blood pressure and enhance cardiovascular protection. Materials and Methods: A sensitive, reliable and selective tandem mass spectrometry (LC-MS/MS) method has been developed for simultaneous quantification of amlodipine (AML), valsartan (VAL) and hydrochlorothiazide (HCTZ) in human plasma. Read More

Background: Meloxicam is a non-steroidal anti-inflammatory drug, known to inhibit cyclooxygenase, a key enzyme of prostaglandin biosynthesis at the site of inflammation. Objectives: Two sensitive and fast spectrophotometric methods (direct and indirect) using flOW INJection Analysis (FIA) have been described for the assay of meloxicam in pure and in pharmaceutical formulations. Methods: The direct method (method A) d Read More

Background: There is no worldwide recognized reference internal quality control method for Therapeutic Drug Monitoring (TDM) of voriconazole (VCZ) by Liquid Chromatography (LC). In this study, we aimed to develop an internal quality control method for TDM of VCZ, evaluate it by the Westgard multi-rule theory, and guarantee the analytical quality of the assays. Methods: The plasma concentration of VCZ was detected Read More

Background: Schisandra chinensis Turcz. (Baill.) is a perennial deciduous woody vine plant, which is beneficial to all systems of the body. Objective: The goals of the present study were to compare the pharmacokinetics of schisandrol B in rats after the oral administration of schisandrol B monomer (10 mg/kg) and S. chinensis extract (equivalent to 10 mg/kg schisandrol B) and to explore interactions among the component Read More

Background: Linifanib (LFB) is a tyrosine kinase inhibitor with antineoplastic activity. The existing methods for the analysis of LFB in bulk and dosage forms do not meet the requirements of quality control (QC) analysis. Objective: The present study was devoted to the development of two methods with high throughputs for determination of LFB. These methods are 96-microwell plate assay with microplate fluorescence reader (MWP Read More

Background: The main goal of process-related substances investigations is to understand how impurities should be controlled during the synthetic or purification process to produce a high-quality drug substance. The simultaneous determination of related substances is a very important factor in the quality control of API and pharmaceutical dosage forms. Methods: A new HPLC method was developed for the simultaneous analy Read More