Current Organic Chemistry - Volume 9, Issue 7, 2005

Advances in transition metal (TM)-catalyzed organic reactions are occurring at a very fast pace, and staying current with the primary literature is a formidable task. Besides, new developments are often published in the form of communications where the range of substrates and experimental conditions are necessarily narrow. Therefore, medium-sized reviews written by practitioners critically summarizing the recent advances Read More

Water has attracted significant attention as an alternative solvent for homogeneous metal-catalyzed reactions because it is a non-toxic, nonflammable solvent that can allow for simplified recovery of homogeneous catalysts. The use of water as a solvent in palladium-catalyzed cross-coupling reactions is of great academic and industrial interest. Palladium-catalyzed coupling reactions are powerful methods to make ca Read More

This review presents the recent progresses in the transition metal mediated synthetic transformations of heterocumulenes (e.g. carbon dioxide, isocyanates, carbodiimides, ketenes, etc.). Organic transformations featured include cycloadditions, nucleophilic addition, metathesis reactions, and polymerizations. Particular emphasis is placed on catalyzed reactions although in some cases, stoichiometric reactions are also described.

This review summarizes the recent developments in palladium-catalyzed heterocycle synthesis that have been described in the literature from January, 2003 to July 31, 2004. The strategies described herein include heterocycle synthesis via either carbon-carbon or carbon-heteroatom bond-forming ring closure, annulations and cycloadditions that form two bonds in a single process, and methods that permit the elaboration o Read More

This review describes recent progress in the development of homogeneous, metal-mediated, catalytic pathways to synthetically valuable aziridines and sulfonamides. Areas of investigation described within this review include: (a) catalytic copper, iron, and silver-mediated nitrene transfer from the iminoiodinanes to olefins, (b) development of alternative nitrene sources for olefin aziridination, including N-halo-p-toluene sulfonam Read More

Catalytic carbon-carbon bond formation using transition metal complexes typically incorporates the use of an aryl halide or triflate compound (electrophile) in combination with an organometallic reagent (nucleophile). Versatile synthetic methods that allow C-C bond formation of aromatic compounds that proceed through transformation of C-H bonds would be of substantial value. Potential routes for C-C bond formation wit Read More

Among the most significant advances in organic synthesis over the past few decades are those associated with the development of transition metal complexes for their use as catalysts in organic reactions. The discovery that transition metals can also be used to catalyze the addition of B-H bonds to unsaturated substrates has provided the synthetic community with another valuable tool. This review examines recent advanc Read More

Hydroformylation reactions that show branched regioselectivity are reviewed. The mechanism of hydroformylation and the current state of the art in linear selective hydroformylation is briefly discussed prior to a more in depth discussion on synthetically useful branched selective hydroformylation reactions. The review divides these into several different classes; hydroformylation of internal cyclic alkenes, acyclic in Read More

This review describes the literature of nucleophilic additions of organometallic and metal hydride reagents to cyclopropenes with a particular focus on the regiochemical and stereochemical aspects of the addition reactions.