Current Organic Chemistry - Volume 9, Issue 13, 2005

Organic chemistry promoted by indium metal and indium salts is of considerable current interest and a few reviews are available. In these reviews, however, applications to the field of heterocyclic chemistry is only scantily covered and the review "Indium Reagents in Heterocylic chemistry" by Dr. Subodh Kumar from the Department of Chemistry, Guru Nanok Dev University, Amritsar, India will, no doubt, be timely and useful. Et Read More

Indium due to its moderate heterophilicity and recyclability plays significant role in indium catalyzed / mediated reactions of heterocycles. The co-ordination of hetero atom of the heterocycle with indium and the electronic contributions of heteroatoms in the ring provide more versatility in comparison to acyclic and carbocyclic systems. Here, the applications of indium reagents in heterocyclic chemistry have been reviewed. Read More

This paper reviews on application of two Michael reagents - ethyl ethoxymethylenecyanoacetate (EMCA) and diethyl ethoxymethylenemalonate (DEEM, abbreviated also as DEMM, EMME or DEEMM) - in organic synthesis, especially in synthesis of biologically active compounds. The Michael reaction and its mechanism is tersely summarized, followed by examples of diversity of traditional and novel Michael donors and accept Read More

The development of novel synthetic methods for the preparation of condensed aromatic and saturated isoindolones containing one or more heteroatoms is described and several new types of related ring systems are presented. The frequently applied N-acyliminium ion cyclization, the cyclocondensation of dicarbonyl compounds (e.g. γ-oxoacids) with amines and the photoinduced intramolecular ring-closure of N-substit Read More

Both direct and multistep reactions, involving the application of carbonyl compounds, e. g. oxoacids, phthalimides, 2-iodobenzamides or acylhalides, have been developed as novel synthetic routes for the preparation of 3- substituted 2,3-dihydro-1H-isoindol-1-ones, which are reviewed here. Alternatively, reductive or acid-catalyzed rearrangements of certain heterocycles lead to the formation of 3-substituted isoindolon Read More