Current Organic Chemistry - Volume 9, Issue 14, 2005

The data concerning the structure, synthesis and reactivity of six-membered ring spiranes exhibiting carbocycles and heterocycles with oxygen atoms are reviewed. The structural aspects are discussed using specific stereogenic elements and stereochemistry descriptors for spiranes with six-membered rings. The data are supported by high field NMR investigations and molecular structures obtained by X-ray diffractometry. Read More

Addition reactions to imines are relatively less developed compared to those of carbonyl compounds due to low electrophilicity and ease of α-deprotonation. With the use of an appropriate activator, which can coordinate to the imine nitrogen atom, the electrophilicity of the imine can be enhanced and a range of nucleophilic addition reactions becomes possible. When the activator is chiral, it will also create chiral environ Read More

This review reports on recent developments on the structure, biological activities and synthesis of 3- hydroxylpyrrolizidine alkaloids and related compounds.

The chemical and biological properties of anti-inflammatory marine natural products whose mechanism of action involves inhibition of phospholipase A2 (PLA2), an enzyme of key importance in the biosynthesis of proinflammatory chemical signals and mediators, has been reviewed. Remarkably, most marine natural products display a selective inhibition profile against secretory PLA2 enzymes, with little or null ability t Read More