Current Organic Chemistry - Volume 9, Issue 18, 2005

The Editor-in-Chief and the management of Current Organic Chemistry decided to devote a special issue to Organophosphorus Chemistry in 2005, to be followed by two more thematic issues in 2006 and 2007. The dedication of one special issue to organophosphorus chemistry, among the annual 18 issues, is a clear recognition of the importance of this subject, the recent trends and achievements of which can be surveyed Read More

Literature publications (up to September 2004) concerning the targeted intervention of organophosphorus synthons in mechanisms of the replicative cycle, and the therapeutic benefits resulting (of particular relevance to anticancer and antiviral therapeutics) are reviewed. DNA-cross-linking agents comprising established oxazaphosphorinanes such as cyclophosphamide, ifosfamide and trofosfamide, and the aziridine a Read More

A structure-based approach to design potent and selective inhibitors is an important component of the modern drug development process. As the altered activity of certain enzymes is associated with variety of pathologies, the design and synthesis of inhibitors for enzymes playing the key role in pathogenesis may result in potential therapeutic agents. Nowadays, the development of new inhibitors is often based on computer as Read More

The last years have seen many advances in the field of organometallic catalysis. Motivating much of the work has been the potential for discovering new catalytic reactions, which can be used for the synthesis of bulky chemicals and fine chemical intermediates. Since the efficiency and the selectivity of the catalyst mainly rely on the structure of the ligand, there is a great interest in the design and the synthesis of ne Read More

Borane complexes of trivalent phosphorus compounds have attracted a continuously growing interest over the past four decades. Their remarkable air and configurational stability combined with a relative easiness of fully stereoretentive removal of the protecting borane moiety quickly made them reagents of choice for the elaboration of phosphine structures especially suited for the preparation of chiral phosphi Read More

Synthetic approaches to both linear and cyclic cyano-substituted phosphines (P∼CN-phosphines) found an industrial application as catalyst precursors, pesticides, herbicides, flame retardants, precursors of aminophosphines etc., are reported. The main synthetic routes include reduction of P=O containing precursors, alkylation of silylphosphines and metal phosphides by halogenoalkyl(aryl)carbonitriles, phosphorylation of Read More