Current Organic Chemistry - Volume 9, Issue 12, 2005

In this review the idea of a “Peptide/Protein World” preceding the widely rooted idea of the “RNA world” is presented and elaborated. To support this idea, the formation of the building blocks of nucleic acids and peptides and their assembly to biopolymers in a primordial earth scenario is discussed. Furthermore, chemical stability problems of the building blocks and the assembled biomolecules are presented, and finally th Read More

The progress in both peptide and polymer chemistry has led to the preparation of “hybrids” to yield compounds with properties not achievable with the separate components. In this review we aim at describing the current synthetic methodologies for the preparation of peptide containing block copolymers, either being completely peptidic or as hybrids with synthetic polymer blocks. The different techniques to prepare these poly Read More

Over the years, γ and δamino acids have gathered much interest in drug discovery, especially in the peptidomimetic area. Much work on γamino acids has been focused towards the generation of γamino butyric acid (GABA) analogues, and the development of asymmetric approaches starting from unsaturated compounds, while few examples have been reported about carbohydrate-derived scaffolds as γamino acids. δAmino Read More

ortho-Phthalaldehyde (OPA) has become the preferred choice over glutaraldehyde for use as a high-level disinfectant for hospital instrument processing. Its superior antimicrobial performance is not well understood. To explain the exceptional microbicidal activity, a multi-step mechanism combining medium or solvent-induced molecular switching between the lipophilic dialdehyde OPA and the amphiphilic non-aldehyde for Read More

The continuous search for new qualities and the desirability of controlling the size, shape and the chemical features had led to the successful synthesis of various molecular containers and their complexes starting from resorcarene skeleton. The rigidified cavitands have been extended to capture in their round hug bigger and bigger molecules. By covalent synthesis many kinds of new hosts have been built, that maintain g Read More