Current Organic Chemistry - Volume 9, Issue 10, 2005

Isoxazoles are a class of heterocyclic compounds having a remarkable number of applications and have been demonstrated to be very versatile building blocks in organic synthesis. The wide range of biological activities includes pharmacological properties such as hypoglycemic, analgesic, antiinflammatory, anti-bacterial and HIV-inhibitory activity. Some isoxazole derivatives display agrochemical properties namely herbicida Read More

Room temperature ionic liquids (RTILs) are a rapidly growing area of chemistry. Although much of the interest has been focussed on the applications of these materials, there has also been significant effort directed toward extending the range of types of these materials. Unfortunately, information about the physical properties of these compounds is often poorly reported and difficult to find. The purpose o Read More

One popular model suggests that life on Earth originates from a prebiotic soup, which is the idea that a large amount of different elements spontaneously came together in a pool to form basic organic moleculars. These basic organic moleculars are believed to have then condensed and reacted to form more complex organic moleculars and then eventually formed the original life. In the process of chemical evolution, the Read More

The 5'-terminus of eukaryotic messenger RNA (mRNA) molecules contains an unique structure, viz. a dinucleoside 5',5'-triphosphate moiety where the terminal nucleoside is 7-methylguanosine. This 5'-cap structure serves as a site of recognition for numerous enzymes involved in splicing, transport and translation of mRNA, and protects mRNA against intracellular exonucleases. In addition, viral RNA polymerases use cappe Read More