Current Organic Chemistry - Volume 29, Issue 11, 2025

Compounds containing the 1,2,4-triazole substructure have been shown to have broad biological activities. Many drugs with a 1,2,4-triazole structure have been developed and proven: for example, ribavirin (antiviral), fluconazole, itraconazole, voriconazole (antifungal), alprazolam (tranquilizer), estazolam (hypnotic, sedative), anastrozole, vorozole and letrozole (as non-steroidal aromatase inhibitors). Given the impo Read More

The crucial need for sustainable and ecologically benign synthetic methodologies has propelled the exploration of catalytic systems that symbolize green chemistry principles. Zirconia, known for its exceptional catalytic properties and environmental compatibility, emerges as a promising catalyst for the synthesis of heterocyclic compounds. Parallelly, the one-pot multicomponent approach enhances the efficiency of the sy Read More

Imidazoline is often a heterogeneous 5-membered ring structure with two nitrogen atoms. The heterocyclic compounds with an imidazoline moiety are a promising scaffold for investigating medicinal potential. The imidazoline nucleus with an oxo group at the 5th, 2nd, or 4th position exhibits a wide spectrum of antibacterial and antifungal activity, as well as antiviral, anti-inflammatory, anticancer, analgesic, antihypertensive, an Read More

N-acyl tetrahydrothienopyridine derivatives serve as important structural motifs in bioorganic chemistry. Restricted rotation of C-N bond in such molecules gives rise to two distinct chemical environments. Thienopyridine derivatives 4a-4i were synthesized and characterised by 1H and 13C NMR spectroscopy. The NMR spectra reveal a doubling of signals, which suggests the presence of two rotamers in the solution. Variable Read More