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Volume 29, Issue 11
  • ISSN: 1385-2728
  • E-ISSN: 1875-5348

Abstract

The crucial need for sustainable and ecologically benign synthetic methodologies has propelled the exploration of catalytic systems that symbolize green chemistry principles. Zirconia, known for its exceptional catalytic properties and environmental compatibility, emerges as a promising catalyst for the synthesis of heterocyclic compounds. Parallelly, the one-pot multicomponent approach enhances the efficiency of the synthetic process, offering advantages such as reduced reaction steps, atom economy, and overall resource optimization. The Eco-friendly nature of zirconia catalysts, coupled with the versatility of one-pot multicomponent reactions, not only streamlines synthetic procedures but also addresses the pressing demand for sustainable protocols in contemporary organic synthesis. This comprehensive review systematically explores the current progress in zirconia-catalyzed one-pot multicomponent reactions to get various heterocycles and discusses the key advancements, reaction mechanisms, and the impact of reaction conditions on the catalytic efficiency of zirconia. Insights from this review will lead a path to the development of innovative and environmentally conscious strategies for the generation of diverse heterocycles, catering to the evolving landscape of green chemistry and green practices in the domain of organic synthesis.

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2025-05-06

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/content/journals/coc/10.2174/0113852728348025241114101345
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Eco-Friendly and Facile Synthesis of Diverse Heterocycles via Zirconia Nanoparticles Catalyzed One Pot Multicomponent Reaction
Current Organic Chemistry 29, 869 (2025); https://doi.org/10.2174/0113852728348025241114101345
/content/journals/coc/10.2174/0113852728348025241114101345
/content/journals/coc/10.2174/0113852728348025241114101345
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  • Article Type:     Review Article
Keyword(s): bioactivity; catalytic properties; Green chemistry; heterocycles synthesis; multicomponent reaction; zirconia

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