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Volume 29, Issue 11
  • ISSN: 1385-2728
  • E-ISSN: 1875-5348

Abstract

Compounds containing the 1,2,4-triazole substructure have been shown to have broad biological activities. Many drugs with a 1,2,4-triazole structure have been developed and proven: for example, ribavirin (antiviral), fluconazole, itraconazole, voriconazole (antifungal), alprazolam (tranquilizer), estazolam (hypnotic, sedative), anastrozole, vorozole and letrozole (as non-steroidal aromatase inhibitors). Given the importance of 1,2,4-triazole scaffolds, the synthesis of their derivatives has attracted much attention. This review deals with the synthetic methods of 1,2,4-triazole compounds in the past 20 years and illustrates selected reactions of this class of compounds. Various biological activities of 1,2,4-triazoles as antifungal, antibacterial, anticancer, anticonvulsant, antituberculosis, antiviral, antiparasitic, analgesic, anti-inflammatory, and anthelmintic agents are also discussed.

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Synthesis, Reactions, and Biological Applications of 1,2,4-triazoles: A Review
Current Organic Chemistry 29, 841 (2025); https://doi.org/10.2174/0113852728348836241104024823
/content/journals/coc/10.2174/0113852728348836241104024823
/content/journals/coc/10.2174/0113852728348836241104024823
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  • Article Type:     Review Article
Keyword(s): 1,2,4-Triazole; anticancer; antiviral; biological activity; heterocycles; itraconazole

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