Current Organic Chemistry - Volume 29, Issue 8, 2025

Dihydrocoumarins play pivotal roles as essential components in biologically active molecules, drugs, and flavor and fragrance compounds. In particular, chiral 3,4-dihydrocoumarins exist in natural products, exhibit less toxicity, and possess structural diversity and stability. Consequently, the asymmetric synthesis of these scaffolds has garnered considerable attention within the chemistry community. Recent advancements ha Read More

The Corona virus disease-19 (COVID-19) pandemic challenged the scientific community in the search for developing effective treatments, such as medicine and/or a vaccine candidate. The SARS-CoV-2 virus and its variants, Omega, Omicron, and Delta, remain as a major threat to human health, causing significant morbidity and mortality worldwide. Given that computational methods are thought to be quick, easy, and inex Read More

As a new type of green solvent, ionic liquids have made rapid progress in the fields of organic synthesis, separation, and electrochemistry due to their unique physical and chemical properties. At the same time, the new fluorescence characteristics and good separation and adsorption functions of ionic liquids have gradually developed in the field of environment and food, showing a good application prospect. Based on t Read More

Hydrazides, derivatives of hydrazine, are widely used in pharmaceuticals, polymers, dyes, herbicides, and as chemical preservatives. A notable application is in synthesizing 1,3,4-oxadiazole, an important aromatic compound with a five-membered heterocyclic ring containing two nitrogen atoms and one oxygen atom. Among the four oxadiazole isomers, 1,3,4-oxadiazole is the most significant, used in drug discovery, phar Read More

The synthesis of a novel family selenazolo[3,2-a]pyridin-4-ium derivatives in high yields was developed based on the annulation reactions of 2-pyridineselenenyl chloride with unsaturated heteroatom and heterocyclic compounds. The analogous new thiazolo[3,2-a]pyridin-4-ium derivatives were obtained by the annulation reactions of 2-pyridinesulfenyl chloride. The reactions with vinylic ethers and N-vinylimidazole gave 3-s Read More