Current Organic Chemistry - Volume 29, Issue 6, 2025

This review summarizes the recent trends in the transition-metal-catalyzed C-H bond functionalization approach to access C-branched (hetero)aryl/alkenyl/alkyl glycosides with reaction characteristics and proposed mechanisms. Recently, the transition-metal-catalyzed C-H functionalization has arisen as a groundbreaking and versatile method for producing potent C-branched glycosides feasibly and efficientl Read More

The development of effective therapeutics to control the infections of drug-resistant bacterial strains is the thrust area in medicinal chemistry. The glycoconjugate containing O-antigenic oligosaccharide and a carrier protein linked through a linker can develop an antigen against gram-negative bacteria like Escherichia coli (E. coli), Shigella, Providencia, and Salmonella. Therefore, the chemical synthesis of glycoconjugate vaccine Read More

Chemistry is confronted with the pressing issues of depleting non-renewable fossil resources and the imperative to combat environmental pollution, which is crucial for a sustainable future. Biomass stands out as the sole organic carbon source in nature among the array of sustainable resources available, positioning it as a prime substitute for fossil-derived chemicals and fuels. Extensive research has been conducted on the abun Read More

Bioorthogonal chemistry represents a collection of chemical techniques employing unique functional groups to probe and comprehend biological processes within living organisms. This tool has unparalleled selectivity, exceptional biocompatibility, and moreover, the versatility which all together make it a very powerful protocol for the studying of biological processes and developing new therapeutics. This review offers a Read More