Current Organic Chemistry - Volume 14, Issue 9, 2010

The chemistry of organic fluorine compounds is a rapidly developing area of research because of their importance in biochemical and medicinal applications and material science. Introduction of fluorine atom into biologically active compounds often leads to improvement of chemical, physical properties and biological activity, metabolic stability and selectivity of the parent compounds due to the unique properties of th Read More

In the past twenty years, the development of efficient methods for asymmetric fluorination is one of the most fascinating aspects of modern organofluorine chemistry. Among the many approaches towards the construction of chiral organofluorine compounds containing a fluorine atom bonded directly to a stereogenic center, electrophilic asymmetric fluorination has proven to be particularly effective. In this review, subs Read More

Organofluorine compounds are central importance in the pharmaceutical and agrochemical industries because the replacement of a hydrogen with a fluorine atom in biologically active molecules can be beneficial in terms of physicochemical properties and biological activities. Thus, the development of effective methodologies for the preparation of chiral organic fluorine compounds through C-F bond formation is still a hi Read More

Synthetic studies on fluorinated β-amino acids and β-peptides have expanded rapidly in recent years, and particularly significant are those methods giving access to the target compounds in enantiomerically pure form. Two main strategies have been investigated, namely selective fluorination of appropriate functional groups in β-amino acid frameworks, and exploitation of already fluorinated small molecules for their use as synth Read More

Chiral α-monofluorocarbonyl compounds have recently received much attention and have been often employed as targets for asymmetric synthesis. However, there are relatively few reports describing applications of such compounds compared to other types of organofluorine compounds such as trifluoromethylated compounds and fluoroaromatics in spite of the many potential applications of such compounds. Read More

The active metabolite of vitamin D, 1α,25-dihydroxyvitamin D3 (1), has a wide range of biological activities, making its analogues promising therapeutic agents for the treatment of cancer, psoriasis and osteoporosis. In particular, the stability of the carbonfluorine bond to oxidation has aided in the development of fluorinated vitamin D analogues as catabolism inhibitors. The analogues were synthesized either by classica Read More

The biological importance and activity of fluorinated carbohydrates is a focus of numerous investigations to date. The introduction of fluorine atom(s) can be achieved by a few means such as the classical fluorination, the building block strategy and the radical addition. This is a mini review of carbohydrates containing fluorine atom(s) developed in the past decade. General preparative methods to the fluorinated carbohydrat Read More