Current Organic Chemistry - Volume 14, Issue 8, 2010

Certain cycloalkane-anellated heterocycles undergo rearrangement under basic or acidic conditions via ring-contraction, ringexpansion or ring-opening pathways to afford new or unusual compounds. The reactivities and properties of cycloalkane-fused heterocycles differ significantly from those of heteroaromatic ring systems. Possible mechanisms are also discussed.

Aryl amines and ethers are very important structural motifs of numerous biologically active natural products, important pharmaceutical compounds, polymers in the material science industries and widely used as drugs, dyes, and other fine chemicals. Several studies have earlier been attempted but transition metal mediated protocols have proven more successful results. Conventional Ullmann condensation with coppe Read More

The utility of hydrazonoyl halides as precursors in synthesis of numerous biologically active compounds is presented. The biologically active compounds, that have been covered, include lipogenase, lipoxygenase and cyclo-oxygenase inhibitors, antiinflammatories, phytotoxic agents, herbicides, acaricides and miticides, insecticides, weed controlling agents, antimicrobial agents, central benzodiazepine receptors, antitu Read More

Satins are the most frequently prescribed and efficient drugs for treatment of lipid disorders. These drugs represent one of the most valuable therapeutic classes of compounds in the pharmaceutical sector. Since their discovery as fungal metabolites, many structural modifications have been performed during the past 30 years to obtain structurally refined and even more potent derivatives. These modifications led to the Read More

Heterocyclic compounds are versatile building blocks in organic synthesis. These are important part in various natural products and bioactive compounds. Several methodologies have been developed to synthesize these heterocyclic compounds. This review article covers an updated (published during 2005 to 2008) summary of transition-metal catalyzed approaches for the syntheses of commonring heterocycles cont Read More