Current Organic Chemistry - Volume 14, Issue 5, 2010

After the publication of Organophosphorus (OP) special issues 1-6 of Current Organic Chemistry in recent years, this series may perhaps be regarded to be traditional. As the next step, the 7. OP special issue is announced here. Organophosphorus chemistry hides a lot of exciting fields in itself, such as syntheses, theoretical aspects, bioactivity and a broad spectrum of applicability. In this issue two articles are connected to Read More

The development of O-phosphotyrosine (pTyr) analogues is reviewed, along with their application in peptidomimetic ligands to proteins implicated in disease-states arising from dysfunctional intracellular signal transduction pathways. Salient features of chemical syntheses are critiqued, including those of established mimetics such as 4'-(phosphonomethyl)phenylalanine (Pmp), 4'- (phosphono)phenylalanine (Ppp) and 4'-(phosphon Read More

Pyridinium aldoximes are used as antidotes in organophosphate poisoning. In the reactivation process they form a complex with the organophosphates, even if the serine active site of acetylcholinesterase enzymes has been inactivated by the organophosphorus compounds. Essential disadvantage of the previously used pyridinium aldoximes is the instability and the toxicity of these complexes. Novel pyridiniu Read More

Alkenylphosphines are compounds of great interest in view of their structures. Hence, these phosphorus derivatives bear a carbon- carbon double bond, directly linked to the phosphorus atom. This insaturation may be used as a coordinating part in presence of a metal or as a reactive part in contact with an electrophile. Thus, alkenylphosphines have found numerous applications in various fields of chemistry. They are useful in Read More

This review presents the use of cyclic tri- and pentavalent amidoesters and diamides with a stereogenic phosphorus as chiral stoichiometric auxiliaries in asymmetric synthesis. It shows that these compounds are especially useful for the preparation of selected acyclic enantiomerically (diastereomerically) pure (or enriched) tricoordinated-trivalent and tetracoordinated-pentavalent derivatives and as precursors of stere Read More

Dendrimers are a very special type of hyperbranched polymers, synthesized step by step from a central core, by the repetition of a sequence of reactions. Phosphorus-containing dendrimers, that are dendrimers possessing one phosphorus atom at each branching point, possess numerous properties, most generally due to the presence of multiple functional groups in close proximity, which may induce cooperative effects. S Read More