Current Organic Chemistry - Volume 14, Issue 4, 2010

During the past decades, many novel multicomponent reactions (MCRs) have been added to the chemist's armamentarium and successfully applied to all fields of organic chemistry. By virtue of their inherent convergence and high productivity, together with their exploratory and complexity-generating power, MCRs have naturally become a rapidly evolving field of research and have attracted the attention of both Read More

The Povarov reaction is a multicomponent process involving anilines, carbonyl compounds and activated olefins to afford tetrahydroquinolines. The mechanism of this domino reaction comprises a sequence of steps linking imine formation, a Mannich-type reaction and an intramolecular aromatic electrophilic substitution. Here we analyze the scope of the methodology, with a particular emphasis on mechanistic variations Read More

The use of emerging multicomponent reactions (MCRs) in conjunction with microwave (MW)-assisted chemistry techniques is dramatically reducing chemical waste and reaction times in several organic syntheses and chemical transformations. The MW-assisted MCRs offer rapid and efficient procedures for the introduction of many points of structural diversity into heterocyclic compounds prepared in a straightforward manne Read More

Major aspects of multicomponent synthesis of cyclic frameworks are reviewed with special focus on Knoevenagel-based domino reactions. Particularly, the Knoevenagel-Cycloaddition and the Knoevenagel-Michael cascades are the majority of reaction types which contribute to the building of complicated cyclic molecular scaffolds. Although samples of the other Knoevenagel-induced reactions are not abundant, thei Read More

Multi-component coupling reactions (MCRs) are a powerful synthetic tool to access complex structures from simple precursors via one-pot procedure. Due to various advantages, it provides, over the conventional two component methods, the investigation for the possibility of an MCR in a multi-sequential synthetic strategy towards the total synthesis of a natural product is of prime importance. Indium (III) salts have been Read More