Current Organic Chemistry - Volume 14, Issue 11, 2010

The aim of this review is to emphasize the importance of modified dinucleotide cap analogs and their useful biological and therapeutic applications. Dinucleoside 5'-5'-triphosphates fulfill numerous regulatory, signaling, or energetic functions (mRNA metabolism- synthesis, nucleo-cytoplasmic transport, translation, silencing, and turnover) in biological systems. In this context, we highlight the recent studies on the improvement i Read More

Iron catalysts are extensively used in organic reactions in recent years since iron is one of the most abundant metals on earth, consequently one of the most inexpensive, and environmentally friendly ones, and many iron salts and complexes are commercially available. This comprehensive review attempts to cover the advances of iron-catalyzed organic reactions in the literature from 2007 to Sept 2009, particularly focusing Read More

We describe the synthesis and effect of complexation on photochemical E (trans) to Z (cis) isomerization of lariat azacrown ethers. Lariat azacrown ethers-Ca2+ complexes are characterized by UV-Vis, 1H-NMR and fluorescence techniques. Photostationary state composition of E-Z isomers upon irradiation under direct excitation and complexation with Ca(ClO4)2, quantum yield of photoisomerization, and fluorescence properties a Read More

The [2+2+1]-cycloaddition of an alkyne, an alkene and carbon monoxide known as Pauson-Khand reaction is a powerful way to install two new functional groups and a cycle into a molecule. The great potential of this reaction has thus far been underestimated in the synthesis of pharmacologically active compounds.

In the last decades photocatalyzed organic processes have attracted the great interest, due to their low environmental impact. Various oxidation and reduction processes of organic substrates have been developed as alternative routes to the “classical” synthesis of more complex molecules. In this attempt TiO2 is actually largely studied and employed, especially as catalyst in the organic pollutants photodegradation to produc Read More