Current Organic Chemistry - Volume 14, Issue 19, 2010

This special issue of Current Organic Chemistry is devoted to “Recent advances in chemical analysis of organic compounds”. Organic compounds, synthetic semi-synthetic or natural are often associated with basic processes of life, such as carbohydrates, proteins,nucleic acids, lipids. They can be found in different matrices including environmental samples, food, human biological fluids,pharmaceuticals etc. Their determination i Read More

Taking the advantages of the chemical conversion of analytes through chemical reactions either in the solution or gas phase, very often an instrumental analytical problem can be addressed in a completely different way. This is at large due to the involvement of the chemical resolution in instrumental analysis. This review is focused specifically on contributions of chemical reactions to the development of novel instrumenta Read More

The problems associated with liquid chromatographic analysis of underivatized amino acids are identified and, through reviewing the recent ten years literature, possible solutions are described. Emphasis has been placed on amperometric as well as on multi mode detection. The advantages offered by preliminary voltammetric studies at microelectrodes (under mass transfer conditions similar to those of a flow cell detector) i Read More

Sample preparation is a very important and essential step in environmental analysis. A brief overview of modern sample preparation such as solvent based methods, sorptive, membrane - assisted and instrumental methods which have been recently applied to extract and preconcentrate organic analytes from different environmental matrices, is presented. The different requirements of each methodology (and its modes o Read More

Expression of genetic information is related to the presence of 5-methylcytosine in DNA. The distribution of 5-methylcytosine varies in different tissues and its frequency is drastically modified according to the developmental stage of the cell as well as under pathological conditions. Among other applications, the presence of &ldquoirregular&rdquo 5-methylcytosine distribution is currently used as a marker of carcinogenesis Read More

Since organoselenium species like selenoaminoacids, selenopeptides, alkylselenides etc. and also the inorganic species selenite (Se (IV)) and selenate (Se (VI)) are known to be present in biological liquids and tissues, some of them playing an important role, there is a constant demand to develop or improve current analytical methodologies in order to enable species-specific detection and determination of these species in Read More

The research and development of electrochemical biosensors applied to life sciences during the past years were reviewed in the present article. In the first part of the article, a brief introduction on nanomaterial based electrochemical DNA biosensors is given. In the second part DNA biosensors and transition metal complexes with biological interest are described. Finally, the development trends of electrochemical biosensors in g Read More

The increasing demand for ultra-fast separations has motivated the development of new materials in the field of chromatographic stationary phases. Since High Performance Liquid Chromatography is a powerful and popular technique, the importance of improving existing supports, as well as the development of new types of columns is more than profound. The advent of monolithic columns offered new practical possib Read More

Dental composites are tooth filling materials. Their chemical composition is complex since they are composed of synthetic polymers, ceramic reinforcing fillers, molecules, which promote or modify the polymerization reaction that yields the cross-linked polymer matrix from the dimethacrylate resin monomers, and silane coupling agents, which enable bonding of the reinforcing fillers to the polymer matrix. Each Read More

In recent years there has been considerable interest in the synthesis and separation of enantiomers of organic compounds especially because of their importance in the biochemistry and pharmaceutical industry. Major differences in biological activity have been observed in chiral molecules. These differences in stereochemistry can influence the pharmacological, metabolic or toxicological activity of the finished drug formulati Read More

Impurity profiling of active pharmaceutical ingredients is a critical quality control parameter during all stages of the development, production and stability testing of pharmaceutical formulations. Literature on this is continuously increasing, it is therefore important to keep track on the latest achievements and applications. This review presents an overview of the most recently published results on the analysis of organic impur Read More