Current Organic Chemistry - Volume 14, Issue 6, 2010

Carbohydrates are complex and structurally diverse compounds in nature with key roles in a broad range of life processes, including signal transduction, carcinogenesis and immune responses. Many natural products contain oligosaccharides that are vital for their biological activity. However, the synthesis of complex oligosaccharides and other glycoconjugates is hampered by difficulties associated with the regiosele Read More

Synthesis of racemic polyhydroxylated carbobicyclic derivatives having a decalin or hydrindane structure is reviewed. The emphasis is put on the mechanistic aspects of the formation of such derivatives using various approaches. Biological activity of these compounds is discussed.

This review reports on the synthetic strategies developed for chiral N,P; N,S; and N,O pyridine ligands in the last decade. Asymmetric reactions catalyzed by metal complexes of these ligands will be discussed.

Single enantiomers of functionalised benzopyran-3-amines are widely used in the pharmaceutical industry as building blocks or intermediates in the synthesis of drugs acting as 5-hydroxytryptamine and dopamine receptor ligands, as well as inhibitors of dopamine β-monooxygenase. Several approaches for the preparation of the key benzopyran-3-amine intermediates in optically pure form are discussed, including synthesis a Read More

Synthesis of optically pure polyhydroxylated, carbobicyclic derivatives with the decalin or hydrindane structure is described. The emphasis is put on the application of the useful chirons derived from the chiral pool. This paper presents the methodology which is complementary to the one reviewed in the previous chapter describing the synthesis of the racemic derivatives.