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Volume 2, Issue 1
  • ISSN: 2665-9786
  • E-ISSN: 2665-9794

Abstract

Colon cancer is responsible for increasing the death rate worldwide. Commonly used anticancer drugs have various side effects and their clinical usage must be restricted due to their toxicity.

The present research aimed to evaluate the anticancer potential of . (LS) seeds aqueous extract against azoxymethane/dextran sodium sulfate (AOM/DSS) induced-colon cancer in male albino mice.

Low (200 mg/kg) and high (400 mg/kg) doses of LS seeds extract were used to treat induced colon cancer in different stages.

The present results report that LS treatment for mice with colon cancer especially in high dose, decreases colon polyps/tumor incidence and size, tissues disorder, expression of P53 and increases apoptosis in colon tissue. Moreover, LS decreases micronucleus induction in polychromatic (PCE), increases PCE/normochromatic erythrocytes ratio and decreases the percentage of sperm abnormalities.

The present study reports anticancer potential of LS for induced colorectal cancer mice by ameliorating the inflammatory steps of colon.

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2021-03-01
2024-12-24

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/content/journals/cnt/10.2174/2665978601999200928212236
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Anticancer Potential of Lepidium Sativum Seeds Aqueous Extract on the Azoxymethane/ Dextran Sulfate Sodium-Induced Colon Cancer In vivo
Current Nutraceuticals 2, 78 (2021); https://doi.org/10.2174/2665978601999200928212236
/content/journals/cnt/10.2174/2665978601999200928212236
/content/journals/cnt/10.2174/2665978601999200928212236
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  • Article Type:     Research Article
Keyword(s): azoxymethane; colitis; colorectal cancer; dextran sodium sulfate; Lepidium sativum; male albino mice

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