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Volume 1, Issue 2
  • ISSN: 2666-8629
  • E-ISSN: 2666-8637

Abstract

Background

Given the lack of options for treating infectious diseases, it is urgent to explore new antimicrobials. Plant food historically represents relevant sources of antimicrobial molecules.

Objective

Here, we show that green tea can eradicate biofilms and planktonic cells of clinical isolates of and

Methods

We conducted antimicrobial activity tests (MIC, MBC, MBEC). Cytotoxicity tests were conducted using BGM cells. We used UPLC and GC-MS to detect flavonoids and other relevant phytomolecules. The antioxidant potential was assessed using the ®-carotene bleaching test. The extract was combined to clinically relevant antimicrobial drugs to investigate possible synergism or antagonism.

Results

To the best of our knowledge, MIC values are among the lowest ever described for the alcoholic extract (8 μg/mL). The extract presented elevated antioxidant potential and was not toxic to BGM cells. When the extract was combined to clinically relevant antimicrobial drugs, statistically significant antagonism was frequent for the drugs used against isolates, whilst significant synergism was observed for some drugs used against isolates.

Conclusion

Our data open doors for exploring isolated molecules from green tea extract against bacterial biofilms, and for developing formulations for clinical treatments.

© 2023 Bentham Science Publishers
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2023-09-01
2025-01-24

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/content/journals/cff/10.2174/2666862901666230419092405
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Green Tea (Camellia sinensis) Extract is Effective against Biofilms of Staphylococcus aureus and Pseudomonas aeruginosa, and Interferes on the Activity of Antimicrobial Drugs
Curr Func Foods 1, E190423216032 (2023); https://doi.org/10.2174/2666862901666230419092405
/content/journals/cff/10.2174/2666862901666230419092405
/content/journals/cff/10.2174/2666862901666230419092405
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  • Article Type:     Research Article
Keyword(s): antimicrobial; biofilm; flavonoids; Green tea; Pseudomonas aeruginosa; Staphylococcus aureus

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