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Nanostructured Lipid Carrier-based Topical Gels as Novel Drug Delivery System: A Comprehensive Overview
Authors: Ujjwal Kumar Biswas, Shreeja Sen, Susrita Sharma, Mohana Paul, Amit Kumar Nayak, and and Anindya BoseAvailable online: 18 October 2024More LessNanostructured lipid carriers (NLCs) are lipidic nanocarriers that recover the permanency and capacity of drug payloads. NLCs are well-known as second-generation lipid nanocarriers with an unstructured matrix, presenting potentially advantageous nanocarrier systems with marketable opportunities because of reproducible production methodologies and biocompatible lipidic excipients. These (NLCs) are now recognized Read More
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Fluconazole-loaded Hyaluronic Acid-modified Transfersomal Hydrogels Containing D-panthenol for Ocular Delivery in Fungal Keratitis Management
Authors: Biswarup Das, Amit Kumar Nayak and Subrata MallickAvailable online: 18 October 2024More LessBackground Fungal keratitis (mycotic keratitis) is an eye infection in which the cornea is infected by fungi and such fungal keratitis management can be effectively possible by ocular administration of antifungal drugs. Objective The main objectives of the present research were to develop and evaluate fluconazole-loaded transfersomal hydrogels for ocular delivery in the effective management of fungal keratitis. Methods A 23 f Read More
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Local Delivery of Ginger Extract via a Nanofibrous Membrane Suppresses Human Skin Melanoma B16F10 Cells Growth via Targeting Ras/ERK and PI3K/AKT Signaling Pathways: An In vitro Study
Authors: Wenju Wei, Tianlu Zhang, Bo Yuan and Saeed RohaniAvailable online: 15 October 2024More LessBackground Metastatic melanoma poses a significant threat globally, with a distressingly low ten-year survival rate of only 10%. While FDA-approved treatments such as dacarbazine and high-dose IL-2 have been employed in clinical settings, their limitations underscore the urgent need for more effective therapies. Aims This study aimed to develop a potential anticancer local treatment through the extraction of various Read More
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Nanoparticle-Mediated Transcytosis in Tumor Drug Delivery: Mechanisms, Categories, and Novel Applications
Authors: Nakaooh Doaa, Signa Lon Rolande Detorgma, Kaiyun Yang, Rajae Salama and Wenli ZhangAvailable online: 14 October 2024More LessThe development of nanotechnology-based drug delivery systems has been extensively investigated across various therapies, leading to the creation of numerous nanomedicines for clinical use. However, these nanomedicines have yet to achieve the anticipated therapeutic efficacy in clinical settings, highlighting the urgent need for further research in this area. A primary challenge in nanomedicine research lies in ensu Read More
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Alleviation of Tumor Invasion by the Development of Natural Polymer-based Low-risk Chemotherapeutic Systems – review on the Malignant Carcinoma Treatments
Available online: 14 October 2024More LessIntroduction/Objective The spread of tumors (48% in men and 51% in women), as well as the protection of malignant tumors by stromal cells and complex blood vessels, pose significant challenges to drug delivery to tumors. Modern chemotherapy, on the other hand, addresses tumor growth suppression by at least 60% through versatile formulation systems and numerous modifications to drug delivery systems. The renewabl Read More
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Multi-Stimuli-Responsive Biocompatible Magnetic Nanocarrier as Drug Delivery System to MCF-7 Breast Cancer Cells
Available online: 04 October 2024More LessIntroduction The last strategy in targeted drug delivery systems is to deliver the anticancer drug to the tumor tissue to increase its therapeutic effect and minimize its undesirable side effects. In line with this goal in this research, the redox/pH-responsive disulfide magnetic nanocarriers based on PF127-NH2/L-cysteine-CM-β-CD-FA were synthesized and evaluated in a doxorubicin delivery system. Methods We effectively s Read More
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Advances in Iron Deficiency Anaemia Management: Exploring Novel Drug Delivery Systems and Future Perspectives
Authors: Muskan Saini, Karan Trehan, Shubham Thakur, Anuj Modi and Subheet Kumar JainAvailable online: 25 July 2024More LessIron Deficiency Anaemia (IDA) is a prevalent global health issue characterized by inadequate iron levels in the body, leading to impaired red blood cell production and subsequent anaemia. Traditional treatment approaches for IDA, such as oral iron supplementation, often encounter challenges related to poor compliance, gastrointestinal side effects, and variable absorption rates. As a result, there is a growing interest in explorin Read More
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Preface
Authors: Deng-Guang Yu and He Lv
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