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- Volume 23, Issue 1, 2025
Anti-Infective Agents - Volume 23, Issue 1, 2025
Volume 23, Issue 1, 2025
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Antifungal Resistance in Candida Species: A Bit from the Totality
More LessResistance to antifungals is one of the natural protection processes developed by fungi to promote their persistence. Exposure of fungi to these agents over long periods due to improper prescription or a contaminated environment increases the resistance problem. Microbiology related to fungal species and clinical settings related to the therapeutic failure of antifungal drugs are two concepts used to define resistance. The Read More
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Synthesis, Antibacterial Activity and In Silico Study of 1-(2-ethyl acetate)-2-styryl 5-nitroimidazole Derivatives
BackgroundFor more than six decades, the use of metronidazole has been limited to anaerobic microorganisms. However, there are accounts of metronidazole derivatives exhibiting strong effectiveness against facultative anaerobic bacteria, suggesting that there may be another mechanism of action for metronidazole. Recent studies have shown that the enzyme FabH (β-ketoacyl-acyl carrier protein synthase III), responsible f Read More
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In-vitro Study of HIV-derived Reverse Transcriptase Inhibition
Authors: Hussan Ibne Shoukani, Khudija tul Kubra and Bashir AhmadIntroductionHIV utilizes a reverse transcriptase (RT) enzyme to convert the HIV-RNA into DNA. Inhibition of the reverse transcription mechanism of HIV-RT may serve as a potential therapeutic approach to impede the proliferation of HIV in those who are infected. Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are a type of medication that directly and non-competitively bind to the allosteric site of HIV-RT, inhibiti Read More
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Cefradine Schiff Bases and their Metal Salts as Potential Anti-infective Agents
Authors: Mohsin Ali, Obaid-ur-Rahman Abid, Wajid Rehman, Muhammad Shahid, Shumaila and Hifza KhanIntroductionA series of schiff bases(3-8) were synthesized by the reaction of cefradine with six different aldehydes/ketones.MethodsThese Schiff bases (3-8) were treated with different bases/salts (NaOH, KOH, Ca(OH)2, Ba(OH)2, Ag(NO)3) to get their metal salts. The structures of the products were ascertained by spectroscopic data. The synthesized compounds were tested for biological activities against Staphylococcus aureus Read More
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Isolation, Characterization and Antibacterial Activity Study of Bioactive Compounds from Leaves of Cyphostemma cyphopetalum
BackgroundCyphostemma cyphopetalum is a herbaceous climber species within the Vitaceae family, found in various tropical and subtropical regions of Africa. It has a history of traditional use in Ethiopia for treating various health issues in humans and livestock, including snake bites, rabies, and eczema. Despite its reported ethnomedicinal uses, there is a lack of sufficient scientific literature regarding the isolation and Read More
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Bioprospecting Antibacterial Properties of Fungi Isolated from Kakinada Sea Coast and Eucalyptus Foliage
BackgroundFungi produce a wide range of secondary metabolites with bactericidal or bacteriostatic properties. In search of novel antibacterial compounds recently, many fungi of marine and plant origin have been studied for their antimicrobial properties.AimThis work aimed to study the bioprospecting of marine and endophytic fungi for their antibacterial properties.MethodsIntensive microbiological methods were followe Read More
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Evaluation of Anti-microbial Activity of Novel Polyherbal Lozenges for the Management of Infection
Authors: Kajal Nagpal, Uditi Handa, Anjali Sharma, Deepshi Arora and Fatimah JanBackgroundThe use of commercial tinctures for the design of a formulation with improved anti-microbial activity in a polyherbal lozenge dosage form has not been described.ObjectiveThis study aimed to develop and evaluate the antimicrobial activity of a novel polyherbal lozenge formulation containing Ashwagandha, Neem, and Tulsi tinctures in a single-dose administration. According to previous studies, each of these herbs c Read More
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Formulation and Evaluation of Polyherbal Antidandruff Shampoo
Authors: Uditi Handa, Deepika Sharma, Abhilasha Dubey, Kajal Nagpal, Prerna Sharma, Nidhi Rani and Vishnu MittalIntroductionNowadays, most people are suffering from dandruff which when not treated becomes flaky and causes major damage to the scalp of a person. Dandruff is a common scalp illness caused by the yeast Pittosporum. It is not possible to completely eradicate dandruff; it can only be appropriately handled.MethodsWhen used as indicated, a shampoo's surfactant, often referred to as a surface-active agent, in its prope Read More
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A Review of Traditional Anthelmintic Approaches: Exploring Medicinal Plants and Polyherbal Formulations for Effective and Safe Gastrointestinal Parasite Treatment
Authors: Arzoo Pannu and Parina KumariGastrointestinal parasites have become the most common reason for infection in humans, affecting many people in the world. Helminthic infections pose a large threat to public health in developing countries. The most common parasites of helminths in humans are whipworms (Trichuris trichiura), roundworms (Ascaris lumbricoides), tapeworms (Taenia solium), and hookworms (Ancylostoma duodenale and Necator ameri Read More
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