Anti-Infective Agents - Volume 23, Issue 1, 2025

Resistance to antifungals is one of the natural protection processes developed by fungi to promote their persistence. Exposure of fungi to these agents over long periods due to improper prescription or a contaminated environment increases the resistance problem. Microbiology related to fungal species and clinical settings related to the therapeutic failure of antifungal drugs are two concepts used to define resistance. The Read More

BackgroundFor more than six decades, the use of metronidazole has been limited to anaerobic microorganisms. However, there are accounts of metronidazole derivatives exhibiting strong effectiveness against facultative anaerobic bacteria, suggesting that there may be another mechanism of action for metronidazole. Recent studies have shown that the enzyme FabH (β-ketoacyl-acyl carrier protein synthase III), responsible f Read More

IntroductionHIV utilizes a reverse transcriptase (RT) enzyme to convert the HIV-RNA into DNA. Inhibition of the reverse transcription mechanism of HIV-RT may serve as a potential therapeutic approach to impede the proliferation of HIV in those who are infected. Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are a type of medication that directly and non-competitively bind to the allosteric site of HIV-RT, inhibiti Read More

IntroductionA series of schiff bases(3-8) were synthesized by the reaction of cefradine with six different aldehydes/ketones.MethodsThese Schiff bases (3-8) were treated with different bases/salts (NaOH, KOH, Ca(OH)2, Ba(OH)2, Ag(NO)3) to get their metal salts. The structures of the products were ascertained by spectroscopic data. The synthesized compounds were tested for biological activities against Staphylococcus aureus Read More

BackgroundCyphostemma cyphopetalum is a herbaceous climber species within the Vitaceae family, found in various tropical and subtropical regions of Africa. It has a history of traditional use in Ethiopia for treating various health issues in humans and livestock, including snake bites, rabies, and eczema. Despite its reported ethnomedicinal uses, there is a lack of sufficient scientific literature regarding the isolation and Read More

BackgroundFungi produce a wide range of secondary metabolites with bactericidal or bacteriostatic properties. In search of novel antibacterial compounds recently, many fungi of marine and plant origin have been studied for their antimicrobial properties.AimThis work aimed to study the bioprospecting of marine and endophytic fungi for their antibacterial properties.MethodsIntensive microbiological methods were followe Read More

BackgroundThe use of commercial tinctures for the design of a formulation with improved anti-microbial activity in a polyherbal lozenge dosage form has not been described.ObjectiveThis study aimed to develop and evaluate the antimicrobial activity of a novel polyherbal lozenge formulation containing Ashwagandha, Neem, and Tulsi tinctures in a single-dose administration. According to previous studies, each of these herbs c Read More

IntroductionNowadays, most people are suffering from dandruff which when not treated becomes flaky and causes major damage to the scalp of a person. Dandruff is a common scalp illness caused by the yeast Pittosporum. It is not possible to completely eradicate dandruff; it can only be appropriately handled.MethodsWhen used as indicated, a shampoo's surfactant, often referred to as a surface-active agent, in its prope Read More

Gastrointestinal parasites have become the most common reason for infection in humans, affecting many people in the world. Helminthic infections pose a large threat to public health in developing countries. The most common parasites of helminths in humans are whipworms (Trichuris trichiura), roundworms (Ascaris lumbricoides), tapeworms (Taenia solium), and hookworms (Ancylostoma duodenale and Necator ameri Read More