Epilepsy is the second most typical chronic disorder described by recurrent seizures and uncontrolled electrical signaling from neurons in the cerebral cortex. Stimulated astrocytes along with microglia promote cytokines that cause neuroinflammation leading to a chain reaction of subsequent steps involving neurons as well as endothelial cells along the blood-brain barrier. Inflammation in the brain’s neural network can cause convulsions and epilepsy. T Read More

Despite the availability of numerous anti-hyperglycemic and psychoactive drugs and diverse therapeutic modalities prevention and cure of diabetes-associated mental health problems continue to be a major challenge for medical practitioners. Considerable efforts have been made in many research laboratories including ours to identify the bioactive of traditionally known medicinal or food plants to identify their bioactive that could be used for Read More

Alzheimer's disease is distinguished by gradual changes in behavior because of the aggregation of β-amyloid and τ protein that blocks the signal transduction pathway. It is one of the major problems in the current scenario. It mainly occurs after the age of 60 and eventually leads to memory loss. Nonetheless medicinal plants have therapeutic potential to improve many diseases. Medicinal drugs with their phytoconstituents may offer therapeutic potenti Read More

This comprehensive textbook offers an in-depth exploration of how thyroid hormones influence brain development and function particularly on cellular and molecular mechanisms. Readers will find current insights into the complex interplay between the thyroid and neurological systems making it a valuable resource for researchers advanced learners and clinicians in the fields of endocrinology neuroscience and developmental biology.The book starts Read More

Parkinson's disease (PD) is a progressive neurological condition characterized by bradykinesia rigidity tremors and impaired balance among other motor impairments. The issue arises from dopaminergic neurons located in the spinal column of the brain. This research report examines the therapeutic potential of dopaminergic medications in the management of Parkinson's disease. The central concept of Parkinson's disease (PD) revolves around the noti Read More

Depression has a high prevalence and associated comorbidities. It is still unknown what the molecular basis of depression is regardless of many theories that have been put up to explain it. Many researchers investigate that present-day therapies for depression are ineffective due to their low efficacy delayed onset of action (typically two weeks) and adverse effects. Novel medications that operate more quickly and effectively are thus needed. Several novel m Read More

BackgroundStress-related illnesses and depression are rising in modern society. Selective serotonin reuptake inhibitors as well as other antidepressants are also not very effective and commonly exhibit partial remission suggesting the need for novel therapeutic agents for treating anxiety and depression.ObjectiveThe present study was designed to investigate serotonergic mechanisms in the potential anxiolytic and stress-reducing effect Read More

BackgroundFollowing clinical trials on psilocybin for the treatment of pain anxiety and depression in patients with cancer scientific interest emerged in its use for substance use disorders.MethodsIn this review of the literature we summarize available trials looking at the use of psilocybin in addiction.ResultsOne double-blind randomized clinical trial looked at the effect of psilocybin on heavy drinking in adults diagnosed with alcohol dependence. Several trial Read More

BackgroundMedication-assisted treatment constitutes the gold standard management for patients with opioid use disorder. Many factors can alter the response to medications including genetic variations. In this case report we discuss the presentation of a patient maintained on subcutaneous extended-release buprenorphine formulation who repeatedly presented objective and subjective signs of opioid withdrawal when he was switched from wee Read More

Current Psychopharmacology publishes peer-reviewed expert review articles and single topic guest edited issues on all aspects of pre-clinical and clinical research in psychopharmacology. The journal aims to be the leading forum for expert review articles in the field. The journal also accepts high-level original research articles on outstanding topics of preclinical and clinical psychopharmacology. Data must be published for the first time in Current Psycho Read More