Introduction Endogenous microRNAs (miRNAs) are critical regulators of tumor progression making their role in breast cancer an important area of investigation. Method This study examined the regulation of MSMO1 by miR-584-5p in breast cancer cells. Using bioinformatics and Western blotting we confirmed MSMO1 expression in breast cancer cells and evaluated its effects on cell migration invasion and the AKT signaling pathway. In vivo exp Read More

Introduction Gastric cancer has emerged as one of the major diseases threatening human health. Our previous studies indicated that the anti-cancer bioactive peptide (ACBP) inhibits the initiation and progression of gastric cancer through apoptosis and cell cycle arrest yet the mechanisms remain unclear. To elucidate the relationships between the effects of ACBP and the levels of cell differentiation as well as the functional mechanisms of ACBP we c Read More

Background The role of ZNF165 in only a few tumors has been reported. ZNF165 plays an important role in liver cancer gastric cancer and breast cancer especially in regulating the immune microenvironment promoting tumor cell proliferation and migration and serving as a potential target for immunotherapy. Objective This study aimed to enhance an understanding of how the ZNF165 gene functions and influences cancer development. Methods Using a Read More

Like other vertebrates amphibians possess innate and adaptive immune systems. At the center of the adaptive immune system is the Major Histocompatibility Complex. The important molecules of innate immunity are antimicrobial peptides (AMPs). These peptides are secreted by granular glands in the skin and protect the animal against microorganisms entering its body through the skin. AMPs offer an effective and rapid defense against pa Read More

Introduction Vigna unguiculata (Cowpea) a legume rich in phytochemicals has been traditionally used to improve fertility and treat various ailments. This study used in-silico and in-vivo methods to evaluate the effects of cowpea protein isolate and essential oil on reproductive hormonal and antioxidant indices. Method Forty (40) female rats were divided into eight groups (n=5). After 14 days of treatment hormone levels (progesterone prolactin testostero Read More

With the emergence of the precision medicine era targeting specific proteins has emerged as a pivotal breakthrough in tumor diagnosis and treatment. Apurinic/apyrimidinic Endonuclease 1 (APE1) is a multifunctional protein that plays a crucial role in DNA repair and cellular redox regulation. This article comprehensively explores the fundamental mechanisms of APE1 as a multifunctional enzyme in biology with particular emphasis on its potential si Read More

BackgroundCholelithiasis is the most prevalent inflammatory condition of the gallbladder. The regulation of biological processes including energy homeostasis and control of body weight are key mechanisms that the leptin and melanocortin pathways play a role in Cholelithiasis is the most prevalent inflammatory condition of the gallbladder. There are various risk factors for the development of gallstone disease especially weight gain and obesity is just one o Read More

IntroductionThe progression of type 2 diabetes in humans appears to be linked to the loss of insulin-producing β-cells. One of the major contributors to β-cell loss is the formation of toxic human IAPP amyloid (hIAPP Islet Amyloid Polypeptide amylin) in the pancreas. Inhibiting the formation of toxic hIAPP amyloid could slow if not prevent altogether the progression of type 2 diabetes. Many non-human organisms also express amyloidogenic IAPP variants kno Read More

Immunoproteomics is the branch of proteomics with an emphasis on the study of functional peptides and proteins related to the immune system. Combining proteomics techniques with immunological research aims to uncover the complex interactions of proteins involved in immune responses. This review discusses the methods applications and recent advancements in immunoproteomics highlighting its critical role in understanding immune respons Read More