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2000
Volume 31, Issue 11
  • ISSN: 0929-8665
  • E-ISSN: 1875-5305

Abstract

Despite significant research efforts, Alzheimer's disease (AD), the primary cause of dementia in older adults worldwide, remains a neurological challenge for which there are currently no effective therapies. There are substantial financial, medical, and personal costs associated with this condition. Important pathological features of AD include hyperphosphorylated microtubule-associated protein Tau, the formation of amyloid β (Aβ) peptides from amyloid precursor protein (APP), and continuous inflammation that ultimately results in neuronal death. Important histological markers of AD, amyloid plaques, and neurofibrillary tangles are created when Aβ and hyperphosphorylated Tau build-up. Nevertheless, a thorough knowledge of the molecular players in AD pathophysiology is still elusive. Recent studies have shown how noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), regulate gene expression at the transcriptional and posttranscriptional levels in a variety of diseases, including AD. There is increasing evidence to support the involvement of these ncRNAs in the genesis and progression of AD, making them promising as biomarkers and therapeutic targets. As a result, therapeutic approaches that target regulatory ncRNAs are becoming more popular as potential means of preventing the progression of AD. This review explores the posttranscriptional relationships between ncRNAs and the main AD pathways, highlighting the potential of ncRNAs to advance AD treatment. In AD, ncRNAs, especially miRNAs, change expression and present potential targets for therapy. MiR-346 raises Aβ through APP messenger Ribonucleic Acid (mRNA), whereas miR-107 may decrease Aβ by targeting beta-site amyloid precursor protein cleaving enzyme 1 (BACE1). They are promising early AD biomarkers due to their stability in cerebrospinal fluid (CSF) and blood. Furthermore, additional research is necessary to determine the role that RNA fragments present in AD-related protein deposits play in AD pathogenesis.

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References

  1. PalopJ.J. ChinJ. MuckeL. A network dysfunction perspective on neurodegenerative diseases.Nature2006443711376877310.1038/nature0528917051202
    [Google Scholar]
  2. WalshD.M. MinogueA.M. Sala FrigerioC. FadeevaJ.V. WascoW. SelkoeD.J. The APP family of proteins: Similarities and differences.Biochem. Soc. Trans.200735241642010.1042/BST035041617371289
    [Google Scholar]
  3. SingerO. MarrR.A. RockensteinE. CrewsL. CoufalN.G. GageF.H. VermaI.M. MasliahE. Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model.Nat. Neurosci.20058101343134910.1038/nn153116136043
    [Google Scholar]
  4. DuyckaertsC. DelatourB. PotierM.C. Classification and basic pathology of Alzheimer disease.Acta Neuropathol.2009118153610.1007/s00401‑009‑0532‑119381658
    [Google Scholar]
  5. PalopJ.J. MuckeL. Amyloid-β–induced neuronal dysfunction in Alzheimer’s disease: From synapses toward neural networks.Nat. Neurosci.201013781281810.1038/nn.258320581818
    [Google Scholar]
  6. BertramL. LillC.M. TanziR.E. The genetics of Alzheimer disease: Back to the future.Neuron201068227028110.1016/j.neuron.2010.10.01320955934
    [Google Scholar]
  7. GeninE. HannequinD. WallonD. SleegersK. HiltunenM. CombarrosO. BullidoM.J. EngelborghsS. De DeynP. BerrC. PasquierF. DuboisB. TognoniG. FiévetN. BrouwersN. BettensK. ArosioB. CotoE. Del ZompoM. MateoI. EpelbaumJ. Frank-GarciaA. HelisalmiS. PorcelliniE. PilottoA. FortiP. FerriR. ScarpiniE. SicilianoG. SolfrizziV. SorbiS. SpallettaG. ValdiviesoF. VepsäläinenS. AlvarezV. BoscoP. MancusoM. PanzaF. NacmiasB. BossùP. HanonO. PiccardiP. AnnoniG. SeripaD. GalimbertiD. LicastroF. SoininenH. DartiguesJ-F. KambohM.I. Van BroeckhovenC. LambertJ.C. AmouyelP. CampionD. APOE and Alzheimer disease: A major gene with semi-dominant inheritance.Mol. Psychiatry201116990390710.1038/mp.2011.5221556001
    [Google Scholar]
  8. LogueM.W. SchuM. VardarajanB.N. BurosJ. GreenR.C. GoR.C. GriffithP. ObisesanT.O. ShatzR. BorensteinA. CupplesL.A. LunettaK.L. FallinM.D. BaldwinC.T. FarrerL.A. A comprehensive genetic association study of Alzheimer disease in African Americans.Arch. Neurol.201168121569157910.1001/archneurol.2011.64622159054
    [Google Scholar]
  9. VollmarP. KullmannJ.S. ThiloB. ClaussenM.C. RothhammerV. JacobiH. SellnerJ. NesslerS. KornT. HemmerB. Active immunization with amyloid-beta 1-42 impairs memory performance through TLR2/4-dependent activation of the innate immune system.J. Immunol.2010185106338634710.4049/jimmunol.100176520943998
    [Google Scholar]
  10. MoralesI. FaríasG. MaccioniR.B. Neuroimmunomodulation in the pathogenesis of Alzheimer’s disease.Neuroimmunomodulation201017320220410.1159/00025872420134203
    [Google Scholar]
  11. JonesL. HolmansP.A. HamshereM.L. HaroldD. MoskvinaV. IvanovD. PocklingtonA. AbrahamR. HollingworthP. SimsR. GerrishA. PahwaJ.S. JonesN. StrettonA. MorganA.R. LovestoneS. PowellJ. ProitsiP. LuptonM.K. BrayneC. RubinszteinD.C. GillM. LawlorB. LynchA. MorganK. BrownK.S. PassmoreP.A. CraigD. McGuinnessB. ToddS. HolmesC. MannD. SmithA.D. LoveS. KehoeP.G. MeadS. FoxN. RossorM. CollingeJ. MaierW. JessenF. SchürmannB. van den BusscheH. HeuserI. PetersO. KornhuberJ. WiltfangJ. DichgansM. FrölichL. HampelH. HüllM. RujescuD. GoateA.M. KauweJ.S.K. CruchagaC. NowotnyP. MorrisJ.C. MayoK. LivingstonG. BassN.J. GurlingH. McQuillinA. GwilliamR. DeloukasP. Al-ChalabiA. ShawC.E. SingletonA.B. GuerreiroR. MühleisenT.W. NöthenM.M. MoebusS. JöckelK-H. KloppN. WichmannH-E. RütherE. CarrasquilloM.M. PankratzV.S. YounkinS.G. HardyJ. O’DonovanM.C. OwenM.J. WilliamsJ. OwenM.J. WilliamsJ. Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer’s disease.PLoS One2010511e1395010.1371/journal.pone.001395021085570
    [Google Scholar]
  12. BoutajangoutA. QuartermainD. SigurdssonE.M. Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model.J. Neurosci.20103049165591656610.1523/JNEUROSCI.4363‑10.201021147995
    [Google Scholar]
  13. Zivari-GhaderT. ValiogluF. EftekhariA. AliyevaI. BeylerliO. DavranS. ChoW.C. BeilerliA. KhalilovR. JavadovS. Recent progresses in natural based therapeutic materials for Alzheimer’s disease.Heliyon2024104e2635110.1016/j.heliyon.2024.e2635138434059
    [Google Scholar]
  14. KaradağM. Use of Prunus armeniaca L. seed oil and pulp in health and cosmetic products.Adv. Biol. Earth Sci.20249Special Issue10511010.62476/abess105
    [Google Scholar]
  15. AhmadianE. EftekhariA. SamieiM. Maleki DizajS. VinkenM. The role and therapeutic potential of connexins, pannexins and their channels in Parkinson’s disease.Cell. Signal.20195811111810.1016/j.cellsig.2019.03.01030877035
    [Google Scholar]
  16. KapranovP. ChengJ. DikeS. NixD.A. DuttaguptaR. WillinghamA.T. StadlerP.F. HertelJ. HackermüllerJ. HofackerI.L. BellI. CheungE. DrenkowJ. DumaisE. PatelS. HeltG. GaneshM. GhoshS. PiccolboniA. SementchenkoV. TammanaH. GingerasT.R. RNA maps reveal new RNA classes and a possible function for pervasive transcription.Science200731658301484148810.1126/science.113834117510325
    [Google Scholar]
  17. BerrettaJ. MorillonA. Pervasive transcription constitutes a new level of eukaryotic genome regulation.EMBO Rep.200910997398210.1038/embor.2009.18119680288
    [Google Scholar]
  18. PollardK.S. SalamaS.R. LambertN. LambotM.A. CoppensS. PedersenJ.S. KatzmanS. KingB. OnoderaC. SiepelA. KernA.D. DehayC. IgelH. AresM.Jr VanderhaeghenP. HausslerD. An RNA gene expressed during cortical development evolved rapidly in humans.Nature2006443710816717210.1038/nature0511316915236
    [Google Scholar]
  19. MajerA. BoothS.A. Computational methodologies for studying non-coding RNAs relevant to central nervous system function and dysfunction.Brain Res.2010133813114510.1016/j.brainres.2010.03.09520381467
    [Google Scholar]
  20. YangJ.H. ShaoP. ZhouH. ChenY.Q. QuL.H. deepBase: A database for deeply annotating and mining deep sequencing data.Nucleic Acids Res.201038Database issueSuppl. 1D123D13010.1093/nar/gkp94319966272
    [Google Scholar]
  21. BrosiusJ. Waste not, want not – transcript excess in multicellular eukaryotes.Trends Genet.200521528728810.1016/j.tig.2005.02.01415851065
    [Google Scholar]
  22. FaghihiM.A. ModarresiF. KhalilA.M. WoodD.E. SahaganB.G. MorganT.E. FinchC.E. St LaurentG.III KennyP.J. WahlestedtC. Expression of a noncoding RNA is elevated in Alzheimer’s disease and drives rapid feed-forward regulation of beta-secretase.Nat. Med.200814772373010.1038/nm178418587408
    [Google Scholar]
  23. CaoX. YeoG. MuotriA.R. KuwabaraT. GageF.H. Noncoding RNAs in the mammalian central nervous system.Annu. Rev. Neurosci.20062917710310.1146/annurev.neuro.29.051605.11283916776580
    [Google Scholar]
  24. MehlerM.F. MattickJ.S. Noncoding RNAs and RNA editing in brain development, functional diversification, and neurological disease.Physiol. Rev.200787379982310.1152/physrev.00036.200617615389
    [Google Scholar]
  25. MercerT.R. DingerM.E. MarianiJ. KosikK.S. MehlerM.F. MattickJ.S. Noncoding RNAs in Long-Term Memory Formation.Neuroscientist200814543444510.1177/107385840831918718997122
    [Google Scholar]
  26. TsurudomeK. TsangK. LiaoE.H. BallR. PenneyJ. YangJ.S. ElazzouziF. HeT. ChishtiA. LnenickaG. LaiE.C. HaghighiA.P. The Drosophila miR-310 cluster negatively regulates synaptic strength at the neuromuscular junction.Neuron201068587989310.1016/j.neuron.2010.11.01621145002
    [Google Scholar]
  27. GaoF.B. Context-dependent functions of specific microRNAs in neuronal development.Neural Dev.2010512510.1186/1749‑8104‑5‑2520920300
    [Google Scholar]
  28. QureshiI.A. MehlerM.F. Non-coding RNA networks underlying cognitive disorders across the lifespan.Trends Mol. Med.201117633734610.1016/j.molmed.2011.02.00221411369
    [Google Scholar]
  29. SiegelG. SabaR. SchrattG. microRNAs in neurons: Manifold regulatory roles at the synapse.Curr. Opin. Genet. Dev.201121449149710.1016/j.gde.2011.04.00821561760
    [Google Scholar]
  30. PauliA. RinnJ.L. SchierA.F. Non-coding RNAs as regulators of embryogenesis.Nat. Rev. Genet.201112213614910.1038/nrg290421245830
    [Google Scholar]
  31. MattickJ.S. AmaralP.P. DingerM.E. MercerT.R. MehlerM.F. RNA regulation of epigenetic processes.BioEssays2009311515910.1002/bies.08009919154003
    [Google Scholar]
  32. SuhN. BlellochR. Small RNAs in early mammalian development: From gametes to gastrulation.Development201113891653166110.1242/dev.05623421486922
    [Google Scholar]
  33. LeeR.C. FeinbaumR.L. AmbrosV. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.Cell199375584385410.1016/0092‑8674(93)90529‑Y8252621
    [Google Scholar]
  34. LeeY. KimM. HanJ. YeomK.H. LeeS. BaekS.H. KimV.N. MicroRNA genes are transcribed by RNA polymerase II.EMBO J.200423204051406010.1038/sj.emboj.760038515372072
    [Google Scholar]
  35. CaiX. HagedornC.H. CullenB.R. Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs.RNA200410121957196610.1261/rna.713520415525708
    [Google Scholar]
  36. FabianM.R. SonenbergN. FilipowiczW. Regulation of mRNA Translation and Stability by microRNAs.Annu. Rev. Biochem.201079135137910.1146/annurev‑biochem‑060308‑10310320533884
    [Google Scholar]
  37. EulalioA. HuntzingerE. IzaurraldeE. Getting to the root of miRNA-mediated gene silencing.Cell2008132191410.1016/j.cell.2007.12.02418191211
    [Google Scholar]
  38. VasudevanS. TongY. SteitzJ.A. Switching from repression to activation: MicroRNAs can up-regulate translation.Science200731858581931193410.1126/science.114946018048652
    [Google Scholar]
  39. PlaceR.F. LiL.C. PookotD. NoonanE.J. DahiyaR. MicroRNA-373 induces expression of genes with complementary promoter sequences.Proc. Natl. Acad. Sci. USA200810551608161310.1073/pnas.070759410518227514
    [Google Scholar]
  40. FriedmanR.C. FarhK.K.H. BurgeC.B. BartelD.P. Most mammalian mRNAs are conserved targets of microRNAs.Genome Res.20091919210510.1101/gr.082701.10818955434
    [Google Scholar]
  41. AmaralP.P. ClarkM.B. GascoigneD.K. DingerM.E. MattickJ.S. lncRNAdb: A reference database for long noncoding RNAs.Nucleic Acids Res.201139Database issueD146D15110.1093/nar/gkq113821112873
    [Google Scholar]
  42. WiluszJ.E. SunwooH. SpectorD.L. Long noncoding RNAs: Functional surprises from the RNA world.Genes Dev.200923131494150410.1101/gad.180090919571179
    [Google Scholar]
  43. MagistriM. FaghihiM.A. St LaurentG.III WahlestedtC. Regulation of chromatin structure by long noncoding RNAs: Focus on natural antisense transcripts.Trends Genet.201228838939610.1016/j.tig.2012.03.01322541732
    [Google Scholar]
  44. LamJ.K.W. ChowM.Y.T. ZhangY. LeungS.W.S. siRNA versus miRNA as therapeutics for gene silencing.Mol. Ther. Nucleic Acids201549e25210.1038/mtna.2015.2326372022
    [Google Scholar]
  45. SempereL.F. FreemantleS. Pitha-RoweI. MossE. DmitrovskyE. AmbrosV. Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation.Genome Biol.200453R1310.1186/gb‑2004‑5‑3‑r1315003116
    [Google Scholar]
  46. LandgrafP. RusuM. SheridanR. SewerA. IovinoN. AravinA. PfefferS. RiceA. KamphorstA.O. LandthalerM. LinC. SocciN.D. HermidaL. FulciV. ChiarettiS. FoàR. SchliwkaJ. FuchsU. NovoselA. MüllerR.U. SchermerB. BisselsU. InmanJ. PhanQ. ChienM. WeirD.B. ChoksiR. De VitaG. FrezzettiD. TrompeterH.I. HornungV. TengG. HartmannG. PalkovitsM. Di LauroR. WernetP. MacinoG. RoglerC.E. NagleJ.W. JuJ. PapavasiliouF.N. BenzingT. LichterP. TamW. BrownsteinM.J. BosioA. BorkhardtA. RussoJ.J. SanderC. ZavolanM. TuschlT. A mammalian microRNA expression atlas based on small RNA library sequencing.Cell200712971401141410.1016/j.cell.2007.04.04017604727
    [Google Scholar]
  47. BakM. SilahtarogluA. MøllerM. ChristensenM. RathM.F. SkryabinB. TommerupN. KauppinenS. MicroRNA expression in the adult mouse central nervous system.RNA200814343244410.1261/rna.78310818230762
    [Google Scholar]
  48. LugliG. TorvikV.I. LarsonJ. SmalheiserN.R. Expression of microRNAs and their precursors in synaptic fractions of adult mouse forebrain.J. Neurochem.2008106265066110.1111/j.1471‑4159.2008.05413.x18410515
    [Google Scholar]
  49. Natera-NaranjoO. AschrafiA. GioioA.E. KaplanB.B. Identification and quantitative analyses of microRNAs located in the distal axons of sympathetic neurons.RNA20101681516152910.1261/rna.183331020584895
    [Google Scholar]
  50. SuhM.R. LeeY. KimJ.Y. KimS.K. MoonS.H. LeeJ.Y. ChaK.Y. ChungH.M. YoonH.S. MoonS.Y. KimV.N. KimK.S. Human embryonic stem cells express a unique set of microRNAs.Dev. Biol.2004270248849810.1016/j.ydbio.2004.02.01915183728
    [Google Scholar]
  51. VenturaA. YoungA.G. WinslowM.M. LintaultL. MeissnerA. ErkelandS.J. NewmanJ. BronsonR.T. CrowleyD. StoneJ.R. JaenischR. SharpP.A. JacksT. Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters.Cell2008132587588610.1016/j.cell.2008.02.01918329372
    [Google Scholar]
  52. MakeyevE.V. ZhangJ. CarrascoM.A. ManiatisT. The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing.Mol. Cell200727343544810.1016/j.molcel.2007.07.01517679093
    [Google Scholar]
  53. Dajas-BailadorF. BonevB. GarcezP. StanleyP. GuillemotF. PapalopuluN. microRNA-9 regulates axon extension and branching by targeting Map1b in mouse cortical neurons.Nat. Neurosci.201215569769910.1038/nn.308222484572
    [Google Scholar]
  54. RadhakrishnanB. AnandA. A. P. Role of miRNA-9 in brain development.J Exp Neurosci.20161010112010.4137/JEN.S32843
    [Google Scholar]
  55. ShenoyA. DanialM. BlellochR.H. Let-7 and miR-125 cooperate to prime progenitors for astrogliogenesis.EMBO J.20153491180119410.15252/embj.20148950425715649
    [Google Scholar]
  56. LauP. VerrierJ.D. NielsenJ.A. JohnsonK.R. NotterpekL. HudsonL.D. Identification of dynamically regulated microRNA and mRNA networks in developing oligodendrocytes.J. Neurosci.20082845117201173010.1523/JNEUROSCI.1932‑08.200818987208
    [Google Scholar]
  57. KonopkaW. KirykA. NovakM. HerwerthM. ParkitnaJ.R. WawrzyniakM. KowarschA. MichalukP. DzwonekJ. ArnspergerT. WilczynskiG. MerkenschlagerM. TheisF.J. KöhrG. KaczmarekL. SchützG. MicroRNA loss enhances learning and memory in mice.J. Neurosci.20103044148351484210.1523/JNEUROSCI.3030‑10.201021048142
    [Google Scholar]
  58. GaoJ. WangW.Y. MaoY.W. GräffJ. GuanJ.S. PanL. MakG. KimD. SuS.C. TsaiL.H. A novel pathway regulates memory and plasticity via SIRT1 and miR-134.Nature201046673101105110910.1038/nature0927120622856
    [Google Scholar]
  59. TaganovK.D. BoldinM.P. ChangK.J. BaltimoreD. NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses.Proc. Natl. Acad. Sci. USA200610333124811248610.1073/pnas.060529810316885212
    [Google Scholar]
  60. SuW. AloiM.S. GardenG.A. MicroRNAs mediating CNS inflammation: Small regulators with powerful potential.Brain Behav. Immun.2016521810.1016/j.bbi.2015.07.00326148445
    [Google Scholar]
  61. BeeriM.S. SonnenJ. Brain BDNF expression as a biomarker for cognitive reserve against Alzheimer disease progression.Neurology201686870270310.1212/WNL.000000000000238926819454
    [Google Scholar]
  62. Lima GiacobboB. DoorduinJ. KleinH.C. DierckxR.A.J.O. BrombergE. de VriesE.F.J. Brain-derived neurotrophic factor in brain disorders: Focus on neuroinflammation.Mol. Neurobiol.20195653295331210.1007/s12035‑018‑1283‑630117106
    [Google Scholar]
  63. TianN. CaoZ. ZhangY. MiR-206 decreases brain-derived neurotrophic factor levels in a transgenic mouse model of Alzheimer’s disease.Neurosci. Bull.201430219119710.1007/s12264‑013‑1419‑724604632
    [Google Scholar]
  64. SomkuwarS.S. FannonM.J. StaplesM.C. Zamora-MartinezE.R. NavarroA.I. KimA. QuigleyJ.A. EdwardsS. MandyamC.D. Alcohol dependence-induced regulation of the proliferation and survival of adult brain progenitors is associated with altered BDNF-TrkB signaling.Brain Struct. Funct.201622194319433510.1007/s00429‑015‑1163‑z26659122
    [Google Scholar]
  65. RosaJ.M. PaziniF.L. OlescowiczG. CamargoA. MorettiM. Gil-MohapelJ. RodriguesA.L.S. Prophylactic effect of physical exercise on Aβ1–40-induced depressive-like behavior: Role of BDNF, mTOR signaling, cell proliferation and survival in the hippocampus.Prog. Neuropsychopharmacol. Biol. Psychiatry20199410964610.1016/j.pnpbp.2019.10964631078612
    [Google Scholar]
  66. ArancibiaS. SilholM. MoulièreF. MeffreJ. HöllingerI. MauriceT. Tapia-ArancibiaL. Protective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats.Neurobiol. Dis.200831331632610.1016/j.nbd.2008.05.01218585459
    [Google Scholar]
  67. LiuX.H. GengZ. YanJ. LiT. ChenQ. ZhangQ.Y. ChenZ.Y. Blocking GSK3β-mediated dynamin1 phosphorylation enhances BDNF-dependent TrkB endocytosis and the protective effects of BDNF in neuronal and mouse models of Alzheimer’s disease.Neurobiol. Dis.20157437739110.1016/j.nbd.2014.11.02025484286
    [Google Scholar]
  68. LiW. LiX. XinX. KanP.C. YanY. MicroRNA-613 regulates the expression of brain-derived neurotrophic factor in Alzheimer’s disease.Biosci. Trends201610537237710.5582/bst.2016.0112727545218
    [Google Scholar]
  69. YangQ. ZhaoQ. YinY. miR‑133b is a potential diagnostic biomarker for Alzheimer’s disease and has a neuroprotective role.Exp. Ther. Med.20191842711271810.3892/etm.2019.785531572518
    [Google Scholar]
  70. BrubanJ. VoloudakisG. HuangQ. KajiwaraY. Al RahimM. YoonY. ShioiJ. Gama SosaM.A. ShaoZ. GeorgakopoulosA. RobakisN.K. Presenilin 1 is necessary for neuronal, but not glial, EGFR expression and neuroprotection via γ-secretase-independent transcriptional mechanisms.FASEB J.20152993702371210.1096/fj.15‑27064525985800
    [Google Scholar]
  71. LiuL. JiangX. YuW. Dracohodin perochlorate stimulates fibroblast proliferation via EGFR activation and downstream ERK/CREB and PI3K/Akt/mTOR pathways in vitro.Evid Based Complement Alternat Med.201920196027186
    [Google Scholar]
  72. WangX. XuY. ZhuH. MaC. DaiX. QinC. Downregulated microRNA-222 is correlated with increased p27Kip1 expression in a double transgenic mouse model of Alzheimer’s disease.Mol. Med. Rep.20151257687769210.3892/mmr.2015.433926398571
    [Google Scholar]
  73. LiB. ChohanM.O. Grundke-IqbalI. IqbalK. Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau.Acta Neuropathol.2007113550151110.1007/s00401‑007‑0207‑817372746
    [Google Scholar]
  74. Hernandez-RappJ. RainoneS. GoupilC. DorvalV. SmithP.Y. Saint-PierreM. ValléeM. PlanelE. DroitA. CalonF. CicchettiF. HébertS.S. microRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer’s disease triple transgenic mice.Sci. Rep.2016613095310.1038/srep3095327484949
    [Google Scholar]
  75. WangG. HuangY. WangL.L. ZhangY.F. XuJ. ZhouY. LourencoG.F. ZhangB. WangY. RenR.J. HallidayG.M. ChenS.D. MicroRNA-146a suppresses ROCK1 allowing hyperphosphorylation of tau in Alzheimer’s disease.Sci. Rep.2016612669710.1038/srep2669727221467
    [Google Scholar]
  76. HuC. ZhouH. LiuY. HuangJ. LiuW. ZhangQ. TangQ. ShengF. LiG. ZhangR. ROCK1 promotes migration and invasion of non‑small‑cell lung cancer cells through the PTEN/PI3K/FAK pathway.Int. J. Oncol.201955483384410.3892/ijo.2019.486431485605
    [Google Scholar]
  77. MezacheL. MikhailM. GarofaloM. NuovoG.J. Reduced miR-512 and the elevated expression of its targets cFLIP and MCL1 localize to neurons with hyperphosphorylated tau protein in Alzheimer disease.Appl. Immunohistochem. Mol. Morphol.201523961562310.1097/PAI.000000000000014726258756
    [Google Scholar]
  78. JiangY. XuB. ChenJ. SuiY. RenL. LiJ. ZhangH. GuoL. SunX. Micro-RNA-137 inhibits tau hyperphosphorylation in Alzheimer’s disease and targets the CACNA1C gene in transgenic mice and human neuroblastoma SH-SY5Y cells.Med. Sci. Monit.2018245635564410.12659/MSM.90876530102687
    [Google Scholar]
  79. YangL.B. LindholmK. YanR. CitronM. XiaW. YangX.L. BeachT. SueL. WongP. PriceD. LiR. ShenY. Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease.Nat. Med.2003913410.1038/nm0103‑312514700
    [Google Scholar]
  80. YangG. SongY. ZhouX. DengY. LiuT. WengG. YuD. PanS. MicroRNA-29c targets β-site amyloid precursor protein-cleaving enzyme 1 and has a neuroprotective role in vitro and in vivo.Mol. Med. Rep.20151223081308810.3892/mmr.2015.372825955795
    [Google Scholar]
  81. LeiX. LeiL. ZhangZ. ZhangZ. ChengY. Downregulated miR-29c correlates with increased BACE1 expression in sporadic Alzheimer’s disease.Int. J. Clin. Exp. Pathol.2015821565157425973041
    [Google Scholar]
  82. ZongY. WangH. DongW. QuanX. ZhuH. XuY. HuangL. MaC. QinC. miR-29c regulates BACE1 protein expression.Brain Res.2011139510811510.1016/j.brainres.2011.04.03521565331
    [Google Scholar]
  83. HébertS.S. HorréK. NicolaïL. PapadopoulouA.S. MandemakersW. SilahtarogluA.N. KauppinenS. DelacourteA. De StrooperB. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer’s disease correlates with increased BACE1/β-secretase expression.Proc. Natl. Acad. Sci. USA2008105176415642010.1073/pnas.071026310518434550
    [Google Scholar]
  84. ZhuH.C. WangL.M. WangM. SongB. TanS. TengJ.F. DuanD.X. MicroRNA-195 downregulates Alzheimer’s disease amyloid-β production by targeting BACE1.Brain Res. Bull.201288659660110.1016/j.brainresbull.2012.05.01822721728
    [Google Scholar]
  85. WangW.X. RajeevB.W. StrombergA.J. RenN. TangG. HuangQ. RigoutsosI. NelsonP.T. The expression of microRNA miR-107 decreases early in Alzheimer’s disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1.J. Neurosci.20082851213122310.1523/JNEUROSCI.5065‑07.200818234899
    [Google Scholar]
  86. ChangF. ZhangL.H. XuW.P. JingP. ZhanP.Y. microRNA-9 attenuates amyloidβ-induced synaptotoxicity by targeting calcium/calmodulin-dependent protein kinase kinase 2.Mol. Med. Rep.2014951917192210.3892/mmr.2014.201324603903
    [Google Scholar]
  87. YanC. ChenJ. LiM. XuanW. SuD. YouH. HuangY. ChenN. LiangX. A decrease in hepatic microRNA-9 expression impairs gluconeogenesis by targeting FOXO1 in obese mice.Diabetologia20165971524153210.1007/s00125‑016‑3932‑527003684
    [Google Scholar]
  88. JansonJ. LaedtkeT. ParisiJ.E. O’BrienP. PetersenR.C. ButlerP.C. Increased risk of type 2 diabetes in Alzheimer disease.Diabetes200453247448110.2337/diabetes.53.2.47414747300
    [Google Scholar]
  89. ChengC. LiW. ZhangZ. YoshimuraS. HaoQ. ZhangC. WangZ. MicroRNA-144 is regulated by activator protein-1 (AP-1) and decreases expression of Alzheimer disease-related a disintegrin and metalloprotease 10 (ADAM10).J. Biol. Chem.201328819137481376110.1074/jbc.M112.38139223546882
    [Google Scholar]
  90. MarttinenM. TakaloM. NatunenT. WittrahmR. GabboujS. KemppainenS. LeinonenV. TanilaH. HaapasaloA. HiltunenM. Molecular mechanisms of synaptotoxicity and neuroinflammation in Alzheimer’s disease.Front. Neurosci.20181296310.3389/fnins.2018.0096330618585
    [Google Scholar]
  91. LiuD. ZhaoD. ZhaoY. WangY. ZhaoY. WenC. Inhibition of microRNA-155 Alleviates Cognitive Impairment in Alzheimer’s Disease and Involvement of Neuroinflammation.Curr. Alzheimer Res.201916647348210.2174/156720501666619050314520731456514
    [Google Scholar]
  92. GuedesJ.R. CustódiaC.M. SilvaR.J. de AlmeidaL.P. Pedroso de LimaM.C. CardosoA.L. Early miR-155 upregulation contributes to neuroinflammation in Alzheimer’s disease triple transgenic mouse model.Hum. Mol. Genet.201423236286630110.1093/hmg/ddu34824990149
    [Google Scholar]
  93. HadarA. MilanesiE. WalczakM. Puzianowska-KuźnickaM. KuźnickiJ. SquassinaA. NiolaP. ChillottiC. AttemsJ. GozesI. GurwitzD. SIRT1, miR-132 and miR-212 link human longevity to Alzheimer’s Disease.Sci. Rep.201881846510.1038/s41598‑018‑26547‑629855513
    [Google Scholar]
  94. JiaoF. GongZ. The beneficial roles of SIRT1 in neuroinflammation-related diseases.Oxid. Med. Cell. Longev.2020202011910.1155/2020/678287233014276
    [Google Scholar]
  95. YuanH. JiangC. ZhaoJ. ZhaoY. ZhangY. XuY. GaoX. GuoL. LiuY. LiuK. XuB. SunG. Euxanthone attenuates Aβ1–42-induced oxidative stress and apoptosis by triggering autophagy.J. Mol. Neurosci.201866451252310.1007/s12031‑018‑1175‑230345461
    [Google Scholar]
  96. WuD.C. ZhangM.F. SuS.G. FangH.Y. WangX.H. HeD. XieY.Y. LiuX.H. HEY2, a target of miR-137, indicates poor outcomes and promotes cell proliferation and migration in hepatocellular carcinoma.Oncotarget2016725380523806310.18632/oncotarget.934327191260
    [Google Scholar]
  97. BaiY. FangF. JiangJ. XuF. Extrinsic calcitonin gene-related peptide inhibits hyperoxia-induced alveolar epithelial type II cells apoptosis, oxidative stress, and reactive oxygen species (ROS) production by enhancing notch 1 and homocysteine-induced endoplasmic reticulum protein (HERP) expression.Med. Sci. Monit.2017235774578210.12659/MSM.90454929206808
    [Google Scholar]
  98. YuanH. DuS. DengY. XuX. ZhangQ. WangM. WangP. SuY. LiangX. SunY. AnZ. Effects of microRNA-208a on inflammation and oxidative stress in ketamine-induced cardiotoxicity through Notch/NF-κB signal pathways by CHD9.Biosci. Rep.2019395BSR2018238110.1042/BSR20182381
    [Google Scholar]
  99. ChenF.Z. ZhaoY. ChenH.Z. MicroRNA-98 reduces amyloid β-protein production and improves oxidative stress and mitochondrial dysfunction through the Notch signaling pathway via HEY2 in Alzheimer’s disease mice.Int. J. Mol. Med.20194319110230365070
    [Google Scholar]
  100. GarciaJ.L. CouceiroJ. Gomez-MoretaJ.A. Gonzalez ValeroJ.M. BrizA.S. SauzeauV. LumbrerasE. DelgadoM. RobledoC. AlmuniaM.L. BusteloX.R. HernandezJ.M. Expression of VAV1 in the tumour microenvironment of glioblastoma multiforme.J. Neurooncol.20121101697710.1007/s11060‑012‑0936‑y22864683
    [Google Scholar]
  101. FryA.L. LaboyJ.T. NormanK.R. VAV-1 acts in a single interneuron to inhibit motor circuit activity in Caenorhabditis elegans.Nat. Commun.201451557910.1038/ncomms657925412913
    [Google Scholar]
  102. YangW.N. MaK.G. ChenX.L. ShiL.L. BuG. HuX.D. HanH. LiuY. QianY.H. Mitogen-activated protein kinase signaling pathways are involved in regulating α7 nicotinic acetylcholine receptor-mediated amyloid-β uptake in SH-SY5Y cells.Neuroscience201427827629010.1016/j.neuroscience.2014.08.01325168732
    [Google Scholar]
  103. ZhouY. WangZ.F. LiW. HongH. ChenJ. TianY. LiuZ.Y. Retracted : Protective effects of microRNA-330 on amyloid β-protein production, oxidative stress, and mitochondrial dysfunction in Alzheimer’s disease by targeting VAV1 via the MAPK signaling pathway.J. Cell. Biochem.201811975437544810.1002/jcb.2670029369410
    [Google Scholar]
  104. ZhongZ. YuanK. TongX. HuJ. SongZ. ZhangG. FangX. ZhangW. MiR-16 attenuates β-amyloid-induced neurotoxicity through targeting β-site amyloid precursor protein-cleaving enzyme 1 in an Alzheimer’s disease cell model.Neuroreport201829161365137210.1097/WNR.000000000000111830142113
    [Google Scholar]
  105. KimJ. YoonH. ChungD. BrownJ.L. BelmonteK.C. KimJ. miR-186 is decreased in aged brain and suppresses BACE 1 expression.J. Neurochem.2016137343644510.1111/jnc.1350726710318
    [Google Scholar]
  106. ZhangY. ZhaoY. AoX. YuW. ZhangL. WangY. ChangW. The role of non-coding RNAs in Alzheimer’s disease: From regulated mechanism to therapeutic targets and diagnostic biomarkers.Front. Aging Neurosci.20211365497810.3389/fnagi.2021.65497834276336
    [Google Scholar]
  107. LiuC. WangJ. LiL. XueL. ZhangY. WangP. MicroRNA-135a and -200b, potential Biomarkers for Alzheimer׳s disease, regulate β secretase and amyloid precursor protein.Brain Res.20141583556410.1016/j.brainres.2014.04.02625152461
    [Google Scholar]
  108. LongJ.M. MaloneyB. RogersJ.T. LahiriD.K. Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5′-untranslated region: Implications in Alzheimer’s disease.Mol. Psychiatry201924334536310.1038/s41380‑018‑0266‑330470799
    [Google Scholar]
  109. XieB. ZhouH. ZhangR. SongM. YuL. WangL. LiuZ. ZhangQ. CuiD. WangX. XuS. Serum miR-206 and miR-132 as potential circulating biomarkers for mild cognitive impairment.J. Alzheimers Dis.201545372173110.3233/JAD‑14284725589731
    [Google Scholar]
  110. ZengQ. ZouL. QianL. ZhouF. NieH. YuS. JiangJ. ZhuangA. WangC. ZhangH. Expression of microRNA-222 in serum of patients with Alzheimer’s disease.Mol. Med. Rep.20171645575557910.3892/mmr.2017.730128849039
    [Google Scholar]
  111. HérardA.S. BesretL. DuboisA. DauguetJ. DelzescauxT. HantrayeP. BonventoG. MoyaK.L. siRNA targeted against amyloid precursor protein impairs synaptic activity in vivo.Neurobiol. Aging200627121740175010.1016/j.neurobiolaging.2005.10.02016337035
    [Google Scholar]
  112. MillerV.M. GouvionC.M. DavidsonB.L. PaulsonH.L. Targeting Alzheimer’s disease genes with RNA interference: An efficient strategy for silencing mutant alleles.Nucleic Acids Res.200432266166810.1093/nar/gkh20814754988
    [Google Scholar]
  113. DrewesG. TrinczekB. IllenbergerS. BiernatJ. Schmitt-UlmsG. MeyerH.E. MandelkowE.M. MandelkowE. Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262.J. Biol. Chem.199527013767976887706316
    [Google Scholar]
  114. PeelA. BredesenD.E. Activation of the cell stress kinase PKR in Alzheimer’s disease and human amyloid precursor protein transgenic mice.Neurobiol. Dis.2003141526210.1016/S0969‑9961(03)00086‑X13678666
    [Google Scholar]
  115. AzorsaD.O. RobesonR.H. FrostD. hoovetB.M. BrautigamG.R. DickeyC. BeaudryC. BasuG.D. HolzD.R. HernandezJ.A. BisanzK.M. GwinnL. GroverA. RogersJ. ReimanE.M. HuttonM. StephanD.A. MoussesS. DunckleyT. High-content siRNA screening of the kinome identifies kinases involved in Alzheimer’s disease-related tau hyperphosphorylation.BMC Genomics20101112510.1186/1471‑2164‑11‑2520067632
    [Google Scholar]
  116. OlufunmilayoE.O. HolsingerR.M.D. Roles of Non-Coding RNA in Alzheimer’s Disease Pathophysiology.Int. J. Mol. Sci.202324151249810.3390/ijms24151249837569871
    [Google Scholar]
  117. HolsingerR.M.D. McLeanC.A. BeyreutherK. MastersC.L. EvinG. Increased expression of the amyloid precursor β-secretase in Alzheimer’s disease.Ann. Neurol.200251678378610.1002/ana.1020812112088
    [Google Scholar]
  118. HolsingerR.M.D. LeeJ.S. BoydA. MastersC.L. CollinsS.J. CSF BACE1 activity is increased in CJD and Alzheimer disease versus other dementias.Neurology200667471071210.1212/01.wnl.0000229925.52203.4c16924032
    [Google Scholar]
  119. HolsingerR.M.D. McLeanC.A. CollinsS.J. MastersC.L. EvinG. Increased β-Secretase activity in cerebrospinal fluid of Alzheimer’s disease subjects.Ann. Neurol.200455689889910.1002/ana.2014415174031
    [Google Scholar]
  120. ZhangW. ZhaoH. WuQ. XuW. XiaM. Knockdown of BACE1‑AS by siRNA improves memory and learning behaviors in Alzheimer’s disease animal model.Exp. Ther. Med.20181632080208610.3892/etm.2018.635930186443
    [Google Scholar]
  121. RoyJ. SarkarA. ParidaS. GhoshZ. MallickB. Small RNA sequencing revealed dysregulated piRNAs in Alzheimer’s disease and their probable role in pathogenesis.Mol. Biosyst.201713356557610.1039/C6MB00699J28127595
    [Google Scholar]
  122. SunZ. WuT. ZhaoF. LauA. BirchC.M. ZhangD.D. KPNA6 (Importin alpha7)-mediated nuclear import of Keap1 represses the Nrf2-dependent antioxidant response.Mol. Cell. Biol.20113191800181110.1128/MCB.05036‑1121383067
    [Google Scholar]
  123. ShaoY. ChenY. Roles of circular RNAs in neurologic disease.Front. Mol. Neurosci.201692510.3389/fnmol.2016.0002527147959
    [Google Scholar]
  124. TatroE.T. RisbroughV. SoontornniyomkijB. YoungJ. Shumaker-ArmstrongS. JesteD.V. AchimC.L. Short-term recognition memory correlates with regional CNS expression of microRNA-138 in mice.Am. J. Geriatr. Psychiatry201321546147310.1016/j.jagp.2012.09.00523570889
    [Google Scholar]
  125. SchröderJ. AnsaloniS. SchillingM. LiuT. RadkeJ. JaedickeM. SchjeideB.M. MashychevA. TegelerC. RadbruchH. PapenbergG. DüzelS. DemuthI. BucholtzN. LindenbergerU. LiS.C. Steinhagen-ThiessenE. LillC.M. BertramL. MicroRNA-138 is a potential regulator of memory performance in humans.Front. Hum. Neurosci.2014850125071529
    [Google Scholar]
  126. HansenT.B. JensenT.I. ClausenB.H. BramsenJ.B. FinsenB. DamgaardC.K. KjemsJ. Natural RNA circles function as efficient microRNA sponges.Nature2013495744138438810.1038/nature1199323446346
    [Google Scholar]
  127. XuH. GuoS. LiW. YuP. The circular RNA Cdr1as, via miR-7 and its targets, regulates insulin transcription and secretion in islet cells.Sci. Rep.2015511245310.1038/srep1245326211738
    [Google Scholar]
  128. Fernández-de FrutosM. Galán-ChiletI. GoedekeL. KimB. Pardo-MarquésV. Pérez-GarcíaA. HerreroJ.I. Fernández-HernandoC. KimJ. RamírezC.M. MicroRNA 7 impairs insulin signaling and regulates a β levels through posttranscriptional regulation of the insulin receptor substrate 2, insulin receptor, insulin-degrading enzyme, and liver x receptor pathway.Mol. Cell. Biol.20193922e00170-1910.1128/MCB.00170‑1931501273
    [Google Scholar]
  129. ZhaoY. AlexandrovP. JaberV. LukiwW. Deficiency in the ubiquitin conjugating enzyme UBE2A in Alzheimer’s disease (AD) is linked to deficits in a natural circular miRNA-7 sponge (circRNA; ciRS-7).Genes (Basel)201671211610.3390/genes712011627929395
    [Google Scholar]
  130. LonskayaI. ShekoyanA.R. HebronM.L. DesforgesN. AlgarzaeN.K. MoussaC.E.H. Diminished parkin solubility and co-localization with intraneuronal amyloid-β are associated with autophagic defects in Alzheimer’s disease.J. Alzheimers Dis.201233123124710.3233/JAD‑2012‑12114122954671
    [Google Scholar]
  131. LukiwW.J. Circular RNA (circRNA) in Alzheimer’s disease (AD).Front. Genet.2013430710.3389/fgene.2013.0030724427167
    [Google Scholar]
  132. ShiZ. ChenT. YaoQ. ZhengL. ZhangZ. WangJ. HuZ. CuiH. HanY. HanX. ZhangK. HongW. The circular RNA ci RS -7 promotes APP and BACE 1 degradation in an NF -κB-dependent manner.FEBS J.201728471096110910.1111/febs.1404528296235
    [Google Scholar]
  133. HuangJ.L. XuZ.H. YangS.M. YuC. ZhangF. QinM.C. ZhouY. ZhongZ.G. WuD.P. Identification of Differentially Expressed Profiles of Alzheimer’s Disease Associated Circular RNAs in a Panax Notoginseng Saponins-Treated Alzheimer’s Disease Mouse Model.Comput. Struct. Biotechnol. J.20181652353110.1016/j.csbj.2018.10.01030524667
    [Google Scholar]
  134. HuangJ.L. JingX. TianX. QinM.C. XuZ.H. WuD.P. ZhongZ.G. Neuroprotective properties of Panax notoginseng saponins via preventing oxidative stress injury in SAMP8 Mice.Evid. Based Complement. Alternat. Med.201720171871356110.1155/2017/871356128250796
    [Google Scholar]
  135. YangH. WangH. ShangH. ChenX. YangS. QuY. DingJ. LiX. Circular RNA circ_0000950 promotes neuron apoptosis, suppresses neurite outgrowth and elevates inflammatory cytokines levels via directly sponging miR-103 in Alzheimer’s disease.Cell Cycle201918182197221410.1080/15384101.2019.162977331373242
    [Google Scholar]
  136. DilingC. YinruiG. LongkaiQ. XiaocuiT. YadiL. XinY. GuoyanH. OuS. TianqiaoY. DongdongW. YizhenX. YangB.B. QingpingW. CircularR.N.A. Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice.Aging (Albany NY)20191124120021203110.18632/aging.10252931860870
    [Google Scholar]
  137. ZhangN. GaoY. YuS. SunX. ShenK. Berberine attenuates Aβ42-induced neuronal damage through regulating circHDAC9/miR-142-5p axis in human neuronal cells.Life Sci.202025211763710.1016/j.lfs.2020.11763732251633
    [Google Scholar]
  138. MagistriM. VelmeshevD. MakhmutovaM. FaghihiM.A. Transcriptomics profiling of Alzheimer’s disease reveal neurovascular defects, altered amyloid-β homeostasis, and deregulated expression of long noncoding RNAs.J. Alzheimers Dis.201548364766510.3233/JAD‑15039826402107
    [Google Scholar]
  139. ZhangJ. ZhangY. TanX. ZhangQ. LiuC. ZhangY. MiR-23b-3p induces the proliferation and metastasis of esophageal squamous cell carcinomas cells through the inhibition of EBF3.Acta Biochim. Biophys. Sin. (Shanghai)201850660561410.1093/abbs/gmy04929750239
    [Google Scholar]
  140. GuC. ChenC. WuR. DongT. HuX. YaoY. ZhangY. Long NoncodingR.N.A. Long noncoding RNA EBF3-AS promotes neuron apoptosis in Alzheimer’s disease.DNA Cell Biol.201837322022610.1089/dna.2017.401229298096
    [Google Scholar]
  141. ParentiR. ParatoreS. TorrisiA. CavallaroS. A natural antisense transcript against Rad18, specifically expressed in neurons and upregulated during β-amyloid-induced apoptosis.Eur. J. Neurosci.20072692444245710.1111/j.1460‑9568.2007.05864.x17970741
    [Google Scholar]
  142. HuangW. LiZ. ZhaoL. ZhaoW. Simvastatin ameliorate memory deficits and inflammation in clinical and mouse model of Alzheimer’s disease via modulating the expression of miR-106b.Biomed. Pharmacother.201792465710.1016/j.biopha.2017.05.06028528185
    [Google Scholar]
  143. ZengT. NiH. YuY. ZhangM. WuM. WangQ. WangL. XuS. XuZ. XuC. XiongJ. JiangJ. LuoY. WangY. LiuH. BACE1-AS prevents BACE1 mRNA degradation through the sequestration of BACE1-targeting miRNAs.J. Chem. Neuroanat.201998879610.1016/j.jchemneu.2019.04.00130959172
    [Google Scholar]
  144. ModarresiF. FaghihiM.A. PatelN.S. SahaganB.G. WahlestedtC. Lopez-ToledanoM.A. Knockdown of BACE1-AS nonprotein-coding transcript modulates beta-amyloid-related hippocampal neurogenesis.Int. J. Alzheimers Dis.20112011192904210.4061/2011/92904221785702
    [Google Scholar]
  145. MusE. HofP.R. TiedgeH. Dendritic BC200 RNA in aging and in Alzheimer’s disease.Proc. Natl. Acad. Sci. USA200710425106791068410.1073/pnas.070153210417553964
    [Google Scholar]
  146. LiH. ZhengL. JiangA. MoY. GongQ. Identification of the biological affection of long noncoding RNA BC200 in Alzheimer’s disease.Neuroreport201829131061106710.1097/WNR.000000000000105729979260
    [Google Scholar]
  147. PuthiyedthN. RiverosC. BerrettaR. MoscatoP. Identification of differentially expressed genes through integrated study of Alzheimer’s disease affected brain regions.PLoS One2016114e015234210.1371/journal.pone.015234227050411
    [Google Scholar]
  148. ZhaoM.Y. WangG.Q. WangN.N. YuQ.Y. LiuR.L. ShiW.Q. The long-non-coding RNA NEAT1 is a novel target for Alzheimer’s disease progression via miR-124/BACE1 axis.Neurol. Res.201941648949710.1080/01616412.2018.154874731014193
    [Google Scholar]
  149. YinR.H. YuJ.T. TanL. The Role of SORL1 in Alzheimer’s Disease.Mol. Neurobiol.201551390991810.1007/s12035‑014‑8742‑524833601
    [Google Scholar]
  150. RogaevaE. MengY. LeeJ.H. GuY. KawaraiT. ZouF. KatayamaT. BaldwinC.T. ChengR. HasegawaH. ChenF. ShibataN. LunettaK.L. Pardossi-PiquardR. BohmC. WakutaniY. CupplesL.A. CuencoK.T. GreenR.C. PinessiL. RaineroI. SorbiS. BruniA. DuaraR. FriedlandR.P. InzelbergR. HampeW. BujoH. SongY.Q. AndersenO.M. WillnowT.E. Graff-RadfordN. PetersenR.C. DicksonD. DerS.D. FraserP.E. Schmitt-UlmsG. YounkinS. MayeuxR. FarrerL.A. St George-HyslopP. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.Nat. Genet.200739216817710.1038/ng194317220890
    [Google Scholar]
  151. CiarloE. MassoneS. PennaI. NizzariM. GigoniA. DieciG. RussoC. FlorioT. CanceddaR. PaganoA. An intronic ncRNA-dependent regulation of SORL1 expression affecting Aβ formation is upregulated in post-mortem Alzheimer’s disease brain samples.Dis. Model. Mech.20136242443322996644
    [Google Scholar]
  152. ZlokovicB.V. DeaneR. SagareA.P. BellR.D. WinklerE.A. Low-density lipoprotein receptor-related protein-1: A serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β-peptide elimination from the brain.J. Neurochem.201011551077108910.1111/j.1471‑4159.2010.07002.x20854368
    [Google Scholar]
  153. StorckS.E. KurtykaM. PietrzikC.U. Brain endothelial LRP1 maintains blood–brain barrier integrity.Fluids Barriers CNS20211812710.1186/s12987‑021‑00260‑534147102
    [Google Scholar]
  154. Van GoolB. StorckS.E. ReekmansS.M. LechatB. GordtsP.L.S.M. PradierL. PietrzikC.U. RoebroekA.J.M. LRP1 has a predominant role in production over clearance of Aβ in a mouse model of Alzheimer’s disease.Mol. Neurobiol.201956107234724510.1007/s12035‑019‑1594‑231004319
    [Google Scholar]
  155. YamanakaY. FaghihiM.A. MagistriM. Alvarez-GarciaO. LotzM. WahlestedtC. Antisense RNA controls LRP1 Sense transcript expression through interaction with a chromatin-associated protein, HMGB2.Cell Rep.201511696797610.1016/j.celrep.2015.04.01125937287
    [Google Scholar]
  156. KicksteinE. KraussS. ThornhillP. RutschowD. ZellerR. SharkeyJ. WilliamsonR. FuchsM. KöhlerA. GlossmannH. SchneiderR. SutherlandC. SchweigerS. Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling.Proc. Natl. Acad. Sci. USA201010750218302183510.1073/pnas.091279310721098287
    [Google Scholar]
  157. LanZ. ChenY. JinJ. XuY. ZhuX. Long non-coding RNA: Insight into mechanisms of Alzheimer’s disease.Front. Mol. Neurosci.20221482100210.3389/fnmol.2021.82100235095418
    [Google Scholar]
  158. RansohoffJ.D. WeiY. KhavariP.A. The functions and unique features of long intergenic non-coding RNA.Nat. Rev. Mol. Cell Biol.201819314315710.1038/nrm.2017.10429138516
    [Google Scholar]
  159. YanY. YanH. TengY. WangQ. YangP. ZhangL. ChengH. FuS. Long non-coding RNA 00507/miRNA-181c-5p/TTBK1/MAPT axis regulates tau hyperphosphorylation in Alzheimer’s disease.J. Gene Med.20202212e326810.1002/jgm.326832891070
    [Google Scholar]
  160. LloydA.G. TateishiS. BieniaszP.D. MuesingM.A. YamaizumiM. MulderL.C.F. Effect of DNA repair protein Rad18 on viral infection.PLoS Pathog.200625e4010.1371/journal.ppat.002004016710452
    [Google Scholar]
  161. HarveyS.H. SheedyD.M. CuddihyA.R. O’ConnellM.J. Coordination of DNA damage responses via the Smc5/Smc6 complex.Mol. Cell. Biol.200424266267410.1128/MCB.24.2.662‑674.200414701739
    [Google Scholar]
  162. MengJ. DingT. ChenY. LongT. XuQ. LianW. LiuW. LncRNA-Meg3 promotes Nlrp3-mediated microglial inflammation by targeting miR-7a-5p.Int. Immunopharmacol.20219010714110.1016/j.intimp.2020.10714133189612
    [Google Scholar]
  163. YiJ. ChenB. YaoX. LeiY. OuF. HuangF. Upregulation of the lncRNA MEG3 improves cognitive impairment, alleviates neuronal damage, and inhibits activation of astrocytes in hippocampus tissues in Alzheimer’s disease through inactivating the PI3K/Akt signaling pathway.J. Cell. Biochem.201912010180531806510.1002/jcb.2910831190362
    [Google Scholar]
  164. TateishiS. SakurabaY. MasuyamaS. InoueH. YamaizumiM. Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens.Proc. Natl. Acad. Sci. USA200097147927793210.1073/pnas.97.14.792710884424
    [Google Scholar]
  165. ZhangX. HamblinM.H. YinK.J. The long noncoding RNA Malat1: Its physiological and pathophysiological functions.RNA Biol.201714121705171410.1080/15476286.2017.135834728837398
    [Google Scholar]
  166. ZhangL. WangH. Long Non-coding RNA in CNS Injuries: A new target for therapeutic intervention.Mol. Ther. Nucleic Acids20191775476610.1016/j.omtn.2019.07.01331437654
    [Google Scholar]
  167. MaP. LiY. ZhangW. FangF. SunJ. LiuM. LiK. DongL. Long non-coding RNA MALAT1 inhibits neuron apoptosis and neuroinflammation while stimulates neurite outgrowth and its correlation with MiR-125b mediates PTGS2, CDK5 and FOXQ1 in Alzheimer’s disease.Curr. Alzheimer Res.201916759661210.2174/156720501666619072513013431345147
    [Google Scholar]
  168. GuoF. TangC. LiY. LiuY. LvP. WangW. MuY. The interplay of Lnc RNA ANRIL and miR-181b on the inflammation-relevant coronary artery disease through mediating NF-κB signalling pathway.J. Cell. Mol. Med.201822105062507510.1111/jcmm.1379030079603
    [Google Scholar]
  169. WeiJ.C. ShiY.L. WangQ. LncRNA ANRIL knockdown ameliorates retinopathy in diabetic rats by inhibiting the NF-κB pathway.Eur. Rev. Med. Pharmacol. Sci.201923187732773931599399
    [Google Scholar]
  170. ZhouB. LiL. QiuX. WuJ. XuL. ShaoW. Long non-coding RNA ANRIL knockdown suppresses apoptosis and pro-inflammatory cytokines while enhancing neurite outgrowth via binding microRNA-125a in a cellular model of Alzheimer’s disease.Mol. Med. Rep.20202221489149710.3892/mmr.2020.1120332626959
    [Google Scholar]
  171. LiH. QiJ. WeiJ. XuB. MinS. WangL. SiY. QiuH. Long non-coding RNA ANRIL mitigates neonatal hypoxic-ischemic brain damage via targeting the miR-378b/ATG3 axis.Am. J. Transl. Res.20211310115851159634786084
    [Google Scholar]
  172. MassoneS. VassalloI. FiorinoG. CastelnuovoM. BarbieriF. BorghiR. TabatonM. RobelloM. GattaE. RussoC. FlorioT. DieciG. CanceddaR. PaganoA. 17A, a novel non-coding RNA, regulates GABA B alternative splicing and signaling in response to inflammatory stimuli and in Alzheimer disease.Neurobiol. Dis.201141230831710.1016/j.nbd.2010.09.01920888417
    [Google Scholar]
  173. ZhangC. LiB. The correlation between LncRNA-17A expression in peripheral blood mononuclear cells and Wnt/β-catenin signaling pathway and cognitive function in patients with Alzheimer disease.Am. J. Transl. Res.20211310119811198634786131
    [Google Scholar]
  174. WangM. QinL. TangB. MicroRNAs in Alzheimer’s Disease.Front. Genet.20191015310.3389/fgene.2019.0015330881384
    [Google Scholar]
  175. ZhangJ. WangR. Deregulated lncRNA MAGI2-AS3 in Alzheimer’s disease attenuates amyloid-β induced neurotoxicity and neuroinflammation by sponging miR-374b-5p.Exp. Gerontol.202114411118010.1016/j.exger.2020.11118033279663
    [Google Scholar]
  176. LiD. WangJ. ZhangM. HuX. SheJ. QiuX. ZhangX. XuL. LiuY. QinS. LncRNA MAGI2-AS3 Is Regulated by BRD4 and Promotes Gastric Cancer Progression via Maintaining ZEB1 Overexpression by Sponging miR-141/200a.Mol. Ther. Nucleic Acids20201910912310.1016/j.omtn.2019.11.00331837602
    [Google Scholar]
  177. TangC. CaiY. JiangH. LvZ. YangC. XuH. LiZ. LiY. LncRNA MAGI2-AS3 inhibits bladder cancer progression by targeting the miR-31-5p/TNS1 axis.Aging (Albany NY)20201224255472556310.18632/aging.10416233231563
    [Google Scholar]
  178. KumarS. VijayanM. ReddyP.H. MicroRNA-455-3p as a potential peripheral biomarker for Alzheimer’s disease.Hum. Mol. Genet.201726193808382210.1093/hmg/ddx26728934394
    [Google Scholar]
  179. MüllerM. KuiperijH.B. ClaassenJ.A. KüstersB. VerbeekM.M. MicroRNAs in Alzheimer’s disease: Differential expression in hippocampus and cell-free cerebrospinal fluid.Neurobiol. Aging201435115215810.1016/j.neurobiolaging.2013.07.00523962497
    [Google Scholar]
  180. WongH.K.A. VeremeykoT. PatelN. LemereC.A. WalshD.M. EsauC. VanderburgC. KrichevskyA.M. De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer’s disease.Hum. Mol. Genet.201322153077309210.1093/hmg/ddt16423585551
    [Google Scholar]
  181. PichlerS. GuW. HartlD. GasparoniG. LeidingerP. KellerA. MeeseE. MayhausM. HampelH. RiemenschneiderM. The miRNome of Alzheimer’s disease: Consistent downregulation of the miR-132/212 cluster.Neurobiol. Aging201750167.e1167.e1010.1016/j.neurobiolaging.2016.09.01927816213
    [Google Scholar]
  182. LongJ.M. LahiriD.K. MicroRNA-101 downregulates Alzheimer’s amyloid-β precursor protein levels in human cell cultures and is differentially expressed.Biochem. Biophys. Res. Commun.2011404488989510.1016/j.bbrc.2010.12.05321172309
    [Google Scholar]
  183. LongJ.M. RayB. LahiriD.K. MicroRNA-153 physiologically inhibits expression of amyloid-β precursor protein in cultured human fetal brain cells and is dysregulated in a subset of Alzheimer disease patients.J. Biol. Chem.201228737312983131010.1074/jbc.M112.36633622733824
    [Google Scholar]
  184. KumarS. ReddyP.H. Are circulating microRNAs peripheral biomarkers for Alzheimer’s disease?Biochim. Biophys. Acta Mol. Basis Dis.2016186291617162710.1016/j.bbadis.2016.06.00127264337
    [Google Scholar]
  185. Shmookler ReisR.J. AtluriR. BalasubramaniamM. JohnsonJ. GanneA. AyyadevaraS. “Protein aggregates” contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation.Aging Cell2021205e1332610.1111/acel.1332633788386
    [Google Scholar]
  186. FakhriS. DarvishE. NarimaniF. MoradiS.Z. AbbaszadehF. KhanH. The regulatory role of non-coding RNAs and their interactions with phytochemicals in neurodegenerative diseases: A systematic review.Brief. Funct. Genomics202322214316010.1093/bfgp/elac05536722043
    [Google Scholar]
  187. SwaminathanG. ShignaA. KumarA. ByrojuV.V. DurgempudiV.R. Dinesh KumarL. RNA interference and nanotechnology: A promising alliance for next generation cancer therapeutics.Front. Nanotechnol.2021369483810.3389/fnano.2021.694838
    [Google Scholar]
  188. SamuelM.S. RavikumarM. John JA. SelvarajanE. PatelH. ChanderP.S. SoundaryaJ. VuppalaS. BalajiR. ChandrasekarN. A review on green synthesis of nanoparticles and their diverse biomedical and environmental applications.Catalysts202212545910.3390/catal12050459
    [Google Scholar]
  189. WuX. XiaP. YangL. LuC. LuZ. The roles of long non-coding RNAs in Alzheimer’s disease diagnosis, treatment, and their involvement in Alzheimer’s disease immune responses.Noncoding RNA Res.20249365966610.1016/j.ncrna.2024.03.00838577023
    [Google Scholar]
  190. EldakhakhnyB. SutaihA.M. SiddiquiM.A. AqeeliY.M. AwanA.Z. AlsayeghM.Y. ElsamanoudyS.A. ElsamanoudyA. Exploring the role of noncoding RNAs in cancer diagnosis, prognosis, and precision medicine.Noncoding RNA Res.2024941315132310.1016/j.ncrna.2024.06.015
    [Google Scholar]
  191. NemethK. BayraktarR. FerracinM. CalinG.A. Non-coding RNAs in disease: From mechanisms to therapeutics.Nat. Rev. Genet.202425321123210.1038/s41576‑023‑00662‑137968332
    [Google Scholar]
  192. BougeaA. GourzisP. Biomarker-based precision therapy for Alzheimer’s Disease: Multidimensional evidence leading a new breakthrough in personalized medicine.J. Clin. Med.20241316466110.3390/jcm1316466139200803
    [Google Scholar]
  193. SpinelliC. AdnaniL. ChoiD. RakJ. Extracellular Vesicles as Conduits of Non-Coding RNA Emission and Intercellular Transfer in Brain Tumors.Noncoding RNA201851110.3390/ncrna501000130585246
    [Google Scholar]
  194. HuesoM. MallénA. Suñé-PouM. AranJ.M. Suñé-NegreJ.M. NavarroE. ncRNAs in therapeutics: Challenges and limitations in nucleic acid-based drug delivery.Int. J. Mol. Sci.202122211159610.3390/ijms22211159634769025
    [Google Scholar]
  195. WinkleM. El-DalyS.M. FabbriM. CalinG.A. Noncoding RNA therapeutics-challenges and potential solutions.Nat. Rev. Drug Discov.202120862965110.1038/s41573‑021‑00219‑z34145432
    [Google Scholar]
  196. Svob StracD. KonjevodM. SagudM. Nikolac PerkovicM. Nedic ErjavecG. VuicB. SimicG. VukicV. MimicaN. PivacN. Pharmacogenomics of dementia: Personalizing the treatment of cognitive and neuropsychiatric symptoms.Genes202314112048
    [Google Scholar]
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