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Volume 3, Issue 1
  • ISSN: 2666-1217
  • E-ISSN: 2666-1225

Abstract

Background

has been used as a traditional medicine to treat various diseases including snakebite envenomation.

Objective

In this study, the protective and ameliorative potentials of crude methanol extract of fruit pulp against crude venom of and were investigated.

Methods

The dose-dependent inhibitory studies, pharmacological, histopathological and studies were conducted using standard methods.

Results

The mean lethal dose of the crude methanolic extract of fruit pulp in rats was > 5,000 mg/kg, while venom was 0.89 mg/kg. The anti-lethality effective concentration of the fruit pulp on venom was 92.52 mg/ml. Treatment significantly ( < 0.05) inhibited the activities of phospholipase A and dose-dependently reduced venom-induced paw oedema at 1-4 hours post-envenomation. , treatment with 250 and 500 mg/kg of fruit pulp was protective against the clinical signs and mortality. Serum acetylcholinesterase activities were maintained in the group treated with normal saline and the ameliorative groups but decreased significantly ( < 0.05) in other groups. Brain acetylcholinesterase was high in all the groups by day 1 but was reduced with increasing dose by day 2 in the ameliorative groups only. fruit pulp also preserved the histoarchitecture of the brain, heart, liver and spleen from venom-induced pathologies.

Conclusion

Crude methanolic extract of fruit pulp possesses good protective and ameliorative neutralization effects on venom and could be promising in the management of snakebite envenomation.

© 2023 Bentham Science Publishers
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2023-01-11
2025-01-31

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/content/journals/vat/10.2174/2666121703666221213122738
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In-vitro and In-vivo Neutralization Activity of Methanol Extract of Adansonia digitata Fruit Pulp against Naja nigricollis Venom
Ven and Tox 3, e131222211909 (2023); https://doi.org/10.2174/2666121703666221213122738
/content/journals/vat/10.2174/2666121703666221213122738
/content/journals/vat/10.2174/2666121703666221213122738
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  • Article Type:     Research Article
Keyword(s): Adansonia digitata; in-vitro; in-vivo; Naja nigricollis; neutralization; Snakebite

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