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Volume 1, Issue 1
  • ISSN: 2666-1217
  • E-ISSN: 2666-1225

Abstract

Natural products are characterized by a complex chemical composition and are capable of concurrently modulate several signalling pathways. Considering the biological complexity of carcinogenesis, natural products represent key components of the therapeutic armamentarium for oncological diseases. The bark of is used in traditional Ayurvedic medicine for its astringent, expectorant, cardiotonic, styptic, and antidysenteric properties. Alongside its traditional uses, exhibits different biological activities including antimutagenic and anticarcinogenic.

This study was designed to evaluate the toxic effects of an alcoholic extract obtained from the bark of on a human T-lymphoblastic cell line (Jurkat). We explored the phytochemical composition and investigated the cytotoxic, cytostatic, genotoxic, and anti-genotoxic effects.

The phytochemical composition was analyzed using spectrophotometric methods; all the biological endpoints were assessed through flow cytometry.

The phytochemical screening showed that polyphenols represent about 64% of the extract. Moreover, the extract was cytotoxic on Jurkat cells by inducing both apoptosis and necrosis, and blocked the cell cycle in the G2/M phase. Additionally, it was found that the extract lacks any genotoxic effect, but was not effective in protecting Jurkat cells from the DNA damage induced by H2O2 and etoposide.

The results of our study show the toxic effects of on Jurkat cells and confirm the pivotal role played by natural compounds in the oncological field. Further studies should be performed to better understand its clinical potential and deepen its toxicological profile.

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2025-03-13

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/content/journals/vat/10.2174/2666121701999200601170928
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The Alcoholic Bark Extract of Terminalia arjuna Exhibits Cytotoxic and Cytostatic Activity on Jurkat Leukemia Cells
Ven and Tox 1, 56 (2021); https://doi.org/10.2174/2666121701999200601170928
/content/journals/vat/10.2174/2666121701999200601170928
/content/journals/vat/10.2174/2666121701999200601170928
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  • Article Type:     Research Article
Keyword(s): antigenotoxicity; cell cycle; cytotoxicity; genotoxicity; leukemia cells; Terminalia arjuna

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