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Volume 18, Issue 2
  • ISSN: 2772-2708
  • E-ISSN: 2772-2716

Abstract

Chronic rhinosinusitis is known as a common problem with inflammatory and allergic causes. Several factors are associated with developing chronic rhinosinusitis, including immunoglobulin E (IgE) production and vitamin D deficiency.

In this study, we investigated the role of IgE and Vitamin D deficiency and differences between patients with chronic, allergic sinusitis and controls.

A total of 90 subjects were included in 3 groups (n=30) in this cross-sectional, correlational descriptive study. The subjects were divided into three groups, including control (healthy subjects), chronic sinusitis patients, and allergy patients. A checklist was used to collect the necessary data, including age, gender, and body mass index (BMI). To evaluate serum levels of vitamin D3 and IgE, ELISA kits were used.

The mean vitamin D was 22 g/ml. Fifty-four participants (60%) out of all included people had insufficient vitamin D, 13% had a deficiency, and the high deficiency and insufficiency were in the group of allergic sinusitis. Our results indicated that gender (female) was significantly associated with vitamin D deficiency ( =0.01). Thirty-nine participants (43.3%) out of all studied subjects had high IgE, and the highest level of abnormality of IgE was in the allergic sinusitis group. Furthermore, it was found that gender and IgE were not significantly related. However, IgE was significantly associated with vitamin D deficiency in the allergic sinusitis group.

Our findings highlighted that most of the patients with chronic and allergic sinusitis had insufficient vitamin D. A possible association was also found between low vitamin D and IgE levels and the prevalence of allergic sinusitis. This study showed that patients with allergic sinusitis may be more vulnerable to lower serum levels of vitamin D. Therefore, vitamin D supplementation as an adjunctive therapy may be considered in these patients.

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2024-09-01
2024-10-22

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References

  1. BachertC. MannentL. NaclerioR.M. Effect of subcutaneous dupilumab on nasal polyp burden in patients with chronic sinusitis and nasal polyposis: A randomized clinical trial.JAMA2016315546947910.1001/jama.2015.1933026836729
     [Google Scholar]
  2. DelemarreT. HoltappelsG. De RuyckN. ZhangN. NauwynckH. BachertC. Type 2 inflammation in chronic rhinosinusitis without nasal polyps: Another relevant endotype.J. Allergy Clin. Immunol.2020146233743.e6
     [Google Scholar]
  3. BellussiL.M. ChenL. ChenD. PassaliF.M. PassaliD. The role of High Mobility Group Box 1 chromosomal protein in the pathogenesis of chronic sinusitis and nasal polyposis.Acta Otorhinolaryngol. Ital.201232638639223349558
     [Google Scholar]
  4. BhattacharyyaN. Functional limitations and workdays lost associated with chronic rhinosinusitis and allergic rhinitis.Am. J. Rhinol. Allergy201226212012210.2500/ajra.2012.26.375222487288
     [Google Scholar]
  5. CollinsJ.G. Prevalence of selected chronic conditions: United States, 1990-1992.Vital Health Stat. 101997194189
     [Google Scholar]
  6. HastanD. FokkensW.J. BachertC. Chronic rhinosinusitis in Europe - an underestimated disease. A GA2LEN study.Allergy20116691216122310.1111/j.1398‑9995.2011.02646.x21605125
     [Google Scholar]
  7. ShiJ.B. FuQ.L. ZhangH. Epidemiology of chronic rhinosinusitis: Results from a cross‐sectional survey in seven C hinese cities.Allergy201570553353910.1111/all.1257725631304
     [Google Scholar]
  8. ChoY.S. ChoiS.H. ParkK.H. Prevalence of otolaryngologic diseases in South Korea: Data from the Korea national health and nutrition examination survey 2008.Clin. Exp. Otorhinolaryngol.20103418319310.3342/ceo.2010.3.4.18321217958
     [Google Scholar]
  9. LiuX. LiuH. LiC. The role of bacterial infection in the pathogenesis of chronic sinusitis. Lin Chuang er bi yan hou tou Jing wai ke za zhi= J Clin.Otorhinolaryngol. Head Neck Surg.2021352189192
     [Google Scholar]
  10. SononeJ. SolankeP. NagpureP.S. GargD. PuttewarM. Effect of anatomical variations of osteomeatal complex on chronic rhinosinusitis: A propective study.Indian J. Otolaryngol. Head Neck Surg.201971S32199220210.1007/s12070‑019‑01653‑731763320
     [Google Scholar]
  11. DejimaK. RandellS.H. StuttsM.J. SeniorB.A. BoucherR.C. Potential role of abnormal ion transport in the pathogenesis of chronic sinusitis.Arch. Otolaryngol. Head Neck Surg.2006132121352136210.1001/archotol.132.12.135217178948
     [Google Scholar]
  12. KennedyJ.L. BorishL. Chronic sinusitis pathophysiology: The role of allergy.Am. J. Rhinol. Allergy201327536737110.2500/ajra.2013.27.390623601202
     [Google Scholar]
  13. BrustadN. KimM. SkovF. 25‐hydroxyvitamin D and risk of atopic diseases and infections in early childhood.Allergy202378102770277310.1111/all.1575937129456
     [Google Scholar]
  14. EmanuelI.A. ShahS.B. Chronic rhinosinusitis: Allergy and sinus computed tomography relationships.Otolaryngol. Head Neck Surg.2000123668769110.1067/mhn.2000.11096111112958
     [Google Scholar]
  15. GutmanM. TorresA. KeenK.J. HouserS.M. Prevalence of allergy in patients with chronic rhinosinusitis.Otolaryngol. Head Neck Surg.2004130554555210.1016/j.otohns.2004.02.00715138418
     [Google Scholar]
  16. HaldermanA.A. TullyL.J. The role of allergy in chronic rhinosinusitis.Otolaryngol. Clin. North Am.20175061077109010.1016/j.otc.2017.08.00328964531
     [Google Scholar]
  17. FawzanA.E. AssiriS.A. AlthaqafiR.M.M. AlsufyaniA. AlghamdiA.S.A. Association of allergic rhinitis with hypothyroidism, asthma, and chronic sinusitis: Clinical and radiological features.World J. Otorhinolaryngol. Head Neck Surg.20228326226810.1016/j.wjorl.2020.12.00136159906
     [Google Scholar]
  18. ZhangC. ZhangH. TangQ. Allergic rhinitis as an independent risk factor for postoperative recurrence of children chronic sinusitis.Children2023107120710.3390/children1007120737508704
     [Google Scholar]
  19. WiseS.K. AhnC.N. SchlosserR.J. Localized immunoglobulin E expression in allergic rhinitis and nasal polyposis.Curr. Opin. Otolaryngol. Head Neck Surg.200917321622210.1097/MOO.0b013e32832ad23d19417663
     [Google Scholar]
  20. Bayar MulukN. BafaqeehS.A. CingiC. Anti-IgE treatment in allergic rhinitis.Int. J. Pediatr. Otorhinolaryngol.201912710967410.1016/j.ijporl.2019.10967431526939
     [Google Scholar]
  21. PintoJ.M. MehtaN. DiTineoM. WangJ. BaroodyF.M. NaclerioR.M. A randomized, double-blind, placebo-controlled trial of anti-IgE for chronic rhinosinusitis.Rhinology201048331832410.4193/Rhino09.14421038023
     [Google Scholar]
  22. AlswailmiF.K. SikandarM.Z. ShahS.I.A. Biological roles of vitamin D and immunoglobulin E: Implications in allergic disorders.Pak. J. Med. Health Sci.2020143495498
     [Google Scholar]
  23. MatheuV. BäckO. MondocE. Issazadeh-NavikasS. Dual effects of vitamin D–induced alteration of TH1/TH2 cytokine expression Enhancing IgE production and decreasing airway eosinophilia in murine allergic airway disease.J. Allergy Clin. Immunol.2003112358559210.1016/S0091‑6749(03)01855‑413679819
     [Google Scholar]
  24. StokesP.J. RimmerJ. The relationship between serum vitamin D and chronic rhinosinusitis: A systematic review.Am. J. Rhinol. Allergy2016301232810.2500/ajra.2016.30.426726867526
     [Google Scholar]
  25. RingeJ.D. KipshovenC. Vitamin D-insufficiency.Dermatoendocrinol201241728010.4161/derm.1982922870356
     [Google Scholar]
  26. SchlosserR.J. SolerZ.M. SchmedesG.W. StorckK. MulliganJ.K. Impact of vitamin D deficiency upon clinical presentation in nasal polyposis.Int. Forum Allergy Rhinol.20144319619910.1002/alr.21274
     [Google Scholar]
  27. MulliganJ.K. BleierB.S. O’ConnellB. MulliganR.M. WagnerC. SchlosserR.J. Vitamin D3 correlates inversely with systemic dendritic cell numbers and bone erosion in chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis.Clin. Exp. Immunol.2011164331232010.1111/j.1365‑2249.2011.04325.x21401575
     [Google Scholar]
  28. PintoJ.M. SchneiderJ. PerezR. DeTineoM. BaroodyF.M. NaclerioR.M. Serum 25-hydroxyvitamin D levels are lower in urban African American subjects with chronic rhinosinusitis.J. Allergy Clin. Immunol.2008122241541710.1016/j.jaci.2008.05.03818585770
     [Google Scholar]
  29. WangL.F. LeeC.H. ChienC.Y. ChenJ.Y.F. ChiangF.Y. TaiC.F. Serum 25-hydroxyvitamin D levels are lower in chronic rhinosinusitis with nasal polyposis and are correlated with disease severity in Taiwanese patients.Am. J. Rhinol. Allergy2013276e162e16510.2500/ajra.2013.27.394824274207
     [Google Scholar]
  30. VerdoiaM. SchafferA. BarbieriL. Impact of gender difference on vitamin D status and its relationship with the extent of coronary artery disease.Nutr. Metab. Cardiovasc. Dis.201525546447010.1016/j.numecd.2015.01.00925791862
     [Google Scholar]
  31. AziziehF. AlyahyaK. RaghupathyR. Association between levels of vitamin D and inflammatory markers in healthy women.J. Inflamm. Res.20169515710.2147/JIR.S10329827175089
     [Google Scholar]
  32. Faghih HabibiA. GeramiH. BananR. Serum 25-hydroxy vitamin D in chronic rhinosinusitis with and without nasal polyposis: A case-control study.Iran. J. Otorhinolaryngol.201931102192430783595
     [Google Scholar]
  33. LatekM. LacwikP. MolińskaK. The role of innate lymphoid cells in chronic rhinosinusitis severity in children: A cross-sectional study.Alergologia Polska202310210010610.5114/pja.2023.129090
     [Google Scholar]
  34. QiuC. ZhongL. HuangC. Cell-bound IgE and plasma IgE as a combined clinical diagnostic indicator for allergic patients.Sci. Rep.2020101470010.1038/s41598‑020‑61455‑832170187
     [Google Scholar]
  35. BrookC.D. AgarwalP. Updates to the current understanding of the relationship between allergy and chronic sinusitis.Curr. Otorhinolaryngol. Rep.20208219119710.1007/s40136‑020‑00287‑6
     [Google Scholar]
  36. RouyarA. ClasseM. GorskiR. Type 2/Th2‐driven inflammation impairs olfactory sensory neurogenesis in mouse chronic rhinosinusitis model.Allergy201974354955910.1111/all.1355929987849
     [Google Scholar]
  37. MirzakhaniH. Al-GarawiA. WeissS.T. LitonjuaA.A. Vitamin D and the development of allergic disease: How important is it?Clin. Exp. Allergy201545111412510.1111/cea.1243025307157
     [Google Scholar]
  38. MohammadzadehI. DarvishS. QujeqD. HajiahmadiM. Vaghari-TabariM. Association of serum 25-OH vitamin D3 with serum IgE and the Pediatric Asthma Severity Score in patients with pediatric asthma. Allergy Asthma Proceedings.OceanSide Publications, Inc.2020
     [Google Scholar]
/content/journals/raiad/10.2174/0127722708281623240116100806
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Evaluation of Serum Levels of Vitamin D3 and IgE in Patients with Chronic and Allergic Sinusitis: A Cross-sectional Study
Rec Adv Inflamm Allergy Drug Discov 18, 108 (2024); https://doi.org/10.2174/0127722708281623240116100806
/content/journals/raiad/10.2174/0127722708281623240116100806
/content/journals/raiad/10.2174/0127722708281623240116100806
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  • Article Type: Research Article
Keyword(s): allergic sinusitis; chronic rhinosinusitis; deficiency; IgE; patients; Vitamin D3

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