Recent Advances in Inflammation & Allergy Drug Discovery - Current Issue

Carrageenan, a naturally occurring polysaccharide derived from red seaweed, has been utilized extensively in the food industry as a stabilizer, thickener, and emulsifier due to its unique gel-forming properties. This versatile compound exists in various forms, including kappa, iota, and lambda, each with distinct characteristics suitable for different applications. Its widespread use as a food additive has raised concerns re Read More

Background: Acne vulgaris, an alternative term for acne, is a persistent inflammatory skin condition affecting the pilosebaceous unit. Its development involves a combination of factors, including increased sebum production, changes in keratinization leading to comedone formation, colonization of hair follicles by Propionibacterium acnes (P. acnes), and the release of inflammatory mediators in the vicinity of the pilos Read More

Over the world, millions of individuals suffer from psoriasis, a chronic inflammatory skin disease. It is caused by a multifaceted mixture of environmental, immunological, and genetic factors. This review explores the many aspects of psoriasis, where the introduction gives a context background, emphasizing the prevalence and difficulties that people encounter with this dermatological ailment. Further, the pathogene Read More

Background: Andrographolide (AP), a bioactive anti-inflammatory compound of Sambiloto, inhibits NF-κB, TNF-α, and interleukin IL-6. Nowadays, molecular docking simulation between AP and dexamethasone against NF-κB receptor presented the energy AP higher than dexamethasone. This becomes a potential treatment for psoriasis.Objective: This manuscript reported the effectiveness of AP from Sambiloto in treating psori Read More

Background: Alopecia is defined by a loss of hair density and is often considered a symptom of multiple illnesses, such as infection and inflammation.Objective: The molecular mechanisms underlying the hair-promoting effects include inhibition of 5α-reductase activity, reducing the binding affinity of Dihydrotestosterone (DHT) to androgen receptors, and decreasing/down-regulating TGF-β2 activity, which have a sugg Read More

BackgroundOsteoarthritis (OA) stands as the most widespread form of arthritis, representing a primary source of pain and functional impairment among the elderly. It is often referred to as a degenerative joint disease. OA is more than just wear and tear; it is an aberrant remodelling of joint tissues prompted by a deluge of inflammatory mediators released within the compromised joint. This disease affects 15 million people in Read More

Background: A neglected zoonosis, Cystic Echinococcosis (CE), is most common in developing nations worldwide. Vaccination is, therefore, helpful in preventing this disease.Objective: Predicting the main biochemical properties of E. granulosus Calreticulin (CRT) and its possible B-cell and T-cell-binding epitopes as a valuable candidate for immunization was the goal of the current study.Methods: Predictions were made to determi Read More

Background: Coronary Artery Bypass Graft (CABG) surgery is employed to increase the lifespan of patients with Coronary Artery Disease (CAD). The low serum levels of essential elements have a negative effect on patients undergoing CABG.Objective: This clinical trial aimed to investigate the effect of trace elements supplements on postoperative outcomes after coronary artery bypass graft.Methods: Two hundred patients und Read More