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2000
Volume 13, Issue 10
  • ISSN: 0929-8665
  • E-ISSN: 1875-5305

Abstract

Rings of rabbit aorta that were both incubated in a high concentration of D-glucose and contracted submaximally by phenylephrine showed significantly decreased endothelium-dependent relaxations induced by acetylcholine. The cGMP production of aorta rings was also reduced. Treatment with endomorphins (1-1000 nmol/L) restored acetylcholineinduced relaxations of aorta rings incubated in high glucose concentrations and increased the cGMP synthesis. Moreover, this effect of endomorphins on endothelium was antagonized by naloxone, and the increase in the production of cGMP was also blocked.

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/content/journals/ppl/10.2174/092986606778777579
2006-10-01
2025-06-11
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