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- Volume 26, Issue 22, 2020
Current Pharmaceutical Design - Volume 26, Issue 22, 2020
Volume 26, Issue 22, 2020
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Inflammatory Related Cardiovascular Diseases: From Molecular Mechanisms to Therapeutic Targets
Authors: Celestino Sardu, Giuseppe Paolisso and Raffaele MarfellaInflammation is a pathogenic response to multiple factors, that causes over-activation of different molecules and pro-inflammatory cellular lines. Different behavioral factors and risk factors might enhance the inflammatory stress, and this might cause cardiovascular disease (CVD). CVD is the world’s leading cause of morbidity and mortality, and it is represented by hypertension, coronary heart disease, cerebrovascular diseas Read More
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Ameliorative Effects and Cellular Aspects of Phytoconstituents in Atherosclerosis
Atherosclerosis is a cardiovascular disease that involves vessels through the development of fatty streaks and plaques. Plant-based compounds can help treat or prevent atherosclerosis by affecting various factors that are involved in the disease. The present review discusses our current knowledge of the major cellular and molecular mechanisms of phytotherapeutics for the treatment of atherosclerosis. Numerous studie Read More
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Inflammasome Signaling and Other Factors Implicated in Atherosclerosis Development and Progression
Authors: Zeinab Nazarian-Samani, Robert D. E. Sewell and Mahmoud Rafieian-KopaeiChronic inflammation plays an extensive role in the onset and progression of metabolic disorders such as atherosclerosis, type 2 diabetes, gout and obesity. Atherosclerosis accounts for up to 70% mortality in patients with type 2 diabetes and is also a chronic condition that causes atrial stenosis due to a lipometabolism imbalance. The purpose of this article is to consider the inflammatory factors implicated in atherosclerosis and Read More
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Mechanisms of Medicinal Plant Activity on Nitric Oxide (NO) Bioavailability as Prospective Treatments for Atherosclerosis
Authors: Khojasteh Malekmohammad, Robert D.E. Sewell and Mahmoud Rafieian-KopaeiBackground and objective: Atherosclerosis is one of the leading causes of human morbidity globally and reduced bioavailability of vascular nitric oxide (NO) has a critical role in the progression and development of the atherosclerotic disease. Loss of NO bioavailability, for example via a deficiency of the substrate (L-arginine) or cofactors for endothelial nitric oxide synthase (eNOS), invariably leads to detrimental vascular Read More
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Current Trends in the Treatment of Systemic Lupus Erythematosus
More LessBackground: Systemic lupus erythematosus (SLE) is an autoimmune disease in mankind. SLE's downregulation of T and B lymphocytes could cause the development of autoantibodies, which in turn attack cell surface, nuclear, and cytoplasmic molecules, creating immune complexes that harm tissues. Objective: The objective of the present review is to evaluate SLE's present therapeutic policies and raise consciousness about th Read More
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Exploiting Anti-Inflammation Effects of Flavonoids in Chronic Inflammatory Diseases
Authors: Tarique Hussain, Ghulam Murtaza, Huansheng Yang, Muhammad S. Kalhoro and Dildar H. KalhoroBackground: Inflammation is a complex response of the host defense system to different internal and external stimuli. It is believed that persistent inflammation may lead to chronic inflammatory diseases such as, inflammatory bowel disease, neurological and cardiovascular diseases. Oxidative stress is the main factor responsible for the augmentation of inflammation via various molecular pathways. Therefore, alleviating oxidati Read More
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Non-pharmacological Strategies Against Systemic Inflammation: Molecular Basis and Clinical Evidence
Systemic inflammation is a common denominator to a variety of cardiovascular (CV) and non-CV diseases and relative risk factors, including hypertension and its control, metabolic diseases, rheumatic disorders, and those affecting the gastrointestinal tract. Besides medications, a non-pharmacological approach encompassing lifestyle changes and other complementary measures is mentioned in several updated guideli Read More
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Impact of Prebiotics on Enteric Diseases and Oxidative Stress
Authors: Jing Gao, Md A.K. Azad, Hui Han, Dan Wan and TieJun LiIn animals, the gastrointestinal microbiota are reported to play a major role in digestion, nutrient absorption and the release of energy through metabolism of food. Therefore, microbiota may be a factor for association between diet and enteric diseases and oxidative stress. The gut microbial composition and concentration are affected by diet throughout the life of an animal, and respond rapidly and efficiently to diet Read More
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Role of the Phytochemical Compounds like Modulators in Gut Microbiota and Oxidative Stress
Background: Currently, daily consumption of green herb functional food or medicinal herbs has increased as adopted by many people worldwide as a way of life or even as an alternative to the use of synthetic medicines. Phytochemicals, which are a series of compounds of relatively complex structures and restricted distribution in plants, usually perform the defensive functions for plants against insects, bacteria, fungi or other Read More
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Conditional Reprogramming Inducing Clinical Cells Proliferation: New Research Tools in Tumor and Inflammatory-related Diseases
Authors: Jie chai, Li Han, Jianbo Zhang, Dali Han, Lei Zou, Ze Zhu, Yulong Zhao and Hongliang GuoIn the era of precision medicine, establishing a patient-derived cell model is crucial, whether in vitro or in vivo. Compared to the traditional cell lines, patient-derived primary cells represent precise genetic features from specific patients, but poor proliferative activity of human primary cells restricts their popular application. Conditional reprogramming (CR) is a new cell culture technique to achieve rapid growth of patient-der Read More
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Treatment of Severe Aplastic Anemia with Porcine Anti-Human Lymphocyte Globulin
Authors: Qi Lv, Zhang Huiqin, Xiao Na, Liu Chunyan, Shao Zonghong and Wang HuaquanAplastic anemia (AA) is a bone marrow failure syndrome characterized by pancytopenia. Decreased numbers of hematopoietic stem cells and impaired bone marrow microenvironment caused by abnormal immune function describe the major pathogenesis of AA. Hematopoietic stem cell transplantation and immunesuppressive therapy are the first-line treatments for AA. Porcine anti-lymphocyte globulin (p-ALG) is a new p Read More
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Current, New and Future Therapeutic Targets in Inflammatory Bowel Disease: A Systematic Review
Authors: Niloufar Alimohammadi, Farzad Koosha and Mahmoud Rafeian-KopaeiInflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), are chronic relapsing conditions resulting from immune system activity in a genetically predisposed individual. IBD is based on progressive damage to the inflamed gut tissue. As its pathogenesis remains unknown, recent accumulating data have demonstrated that IBD is a complex and multi-factorial disorder correlated with host l Read More
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Efficacy of some Herbal Medicines in Osteoarthritis with a Focus on Topical Agents: A Systematic Review
Authors: Sadra Ansaripour and Morteza DehghanOsteoarthritis (OA) is a leading cause of musculoskeletal disorders that mainly affects the elderly population. Some herbal medicines have the potential to alleviate the pain associated with OA and improve physical activity mostly through anti-inflammatory and anti-oxidative properties. The aim of this study was to investigate the effects of herbal medicines, especially topical types, on osteoarthritis. In this systematic review, t Read More
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Erratum: Treatment of Glucocorticoid-Induced Osteoporosis with Bisphosphonates Alone, Vitamin D Alone or a Combination Treatment in Eastern Asians: A Meta-Analysis
Authors: Junjie Wang and Hongzhuo LiDue to an overlook on the author's side, author’s affiliation in the article entitled as: “Treatment of Glucocorticoid-Induced Osteoporosis with Bisphosphonates Alone, Vitamin D Alone or a Combination Treatment in Eastern Asians: A Meta-Analysis” by Dr. Junjie Wang (Co-author) published in the journal “Current Pharmaceutical Design” Volume 25, No 14, Page no- 1653-1662 was incomplete.
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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