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- Volume 26, Issue 29, 2020
Current Pharmaceutical Design - Volume 26, Issue 29, 2020
Volume 26, Issue 29, 2020
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Recognition Pattern, Functional Mechanism and Application of Chitin and Chitosan Oligosaccharides in Sustainable Agriculture
Authors: Xiaochen Jia, Mijanur R. Rajib and Heng YinBackground: Application of chitin attracts much attention in the past decades as the second abundant polysaccharides in the world after cellulose. Chitin oligosaccharides (CTOS) and its deacetylated derivative chitosan oligosaccharides (COS) were shown great potentiality in agriculture by enhancing plant resistance to abiotic or biotic stresses, promoting plant growth and yield, improving fruits quality and storage, etc. Thos Read More
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Chemoenzymatic Synthesis and Function of Chitin Derivatives
By Makoto OgataChitin, abundant biomass found in crab shells and other marine life, has wide applications in the production of food, pharmaceuticals, and cosmetics. Our recent studies have focused on the development of new functional materials by derivatizing chitin oligosaccharides and monosaccharides. For example, we have prepared various derivatives by chemoenzymatic synthesis using N-acetylglucosamine (GlcNAc Read More
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Insect Cuticular Chitin Contributes to Form and Function
Authors: Subbaratnam Muthukrishnan, Seulgi Mun, Mi Y. Noh, Erika R. Geisbrecht and Yasuyuki ArakaneChitin contributes to the rigidity of the insect cuticle and serves as an attachment matrix for other cuticular proteins. Deficiency of chitin results in abnormal embryos, cuticular structural defects and growth arrest. When chitin is not turned over during molting, the developing insect is trapped inside the old cuticle. Partial deacetylation of cuticular chitin is also required for proper laminar organization of the cuticle and vertical p Read More
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Drosophila, Chitin and Insect Pest Management
Authors: Yiwen Wang, Lujuan Gao and Bernard MoussianInsects are a great menace in agriculture and vectors of human diseases. Hence, controlling insect populations is an important issue worldwide. A common strategy to control insects is the application of insecticides. However, insecticides entail three major problems. First, insecticides are chemicals that stress ecosystems and may even be harmful to humans. Second, insecticides are often unspecific and also eradicate ben Read More
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Tribolium castaneum: A Model for Investigating the Mode of Action of Insecticides and Mechanisms of Resistance
Authors: Janin Rösner, Benedikt Wellmeyer and Hans MerzendorferThe red flour beetle, Tribolium castaneum, is a worldwide insect pest of stored products, particularly food grains, and a powerful model organism for developmental, physiological and applied entomological research on coleopteran species. Among coleopterans, T. castaneum has the most fully sequenced and annotated genome and consequently provides the most advanced genetic model of a coleopteran pest. The beetle is als Read More
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Application of Artificial Intelligence in Pharmaceutical and Biomedical Studies
Background: Artificial intelligence (AI) is the way to model human intelligence to accomplish certain tasks without much intervention of human beings. The term AI was first used in 1956 with The Logic Theorist program, which was designed to simulate problem-solving ability of human beings. There have been a significant amount of research works using AI in order to determine the advantages and disadvantages of its Read More
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Trends in Nanomedicines for Cancer Treatment
Background: Cancer is characterized by abnormal cell growth and considered one of the leading causes of death around the world. Pharmaceutical Nanotechnology has been extensively studied for the optimization of cancer treatment. Objective: Comprehend the panorama of Pharmaceutical Nanotechnology in cancer treatment, through a survey about nanomedicines applied in clinical studies, approved for use and patented. Read More
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Mesenchymal Stem Cell-Conditioned Medium Rescues LPS-Impaired ENaC Activity in Mouse Trachea via WNK4 Pathway
Authors: Yapeng Hou, Zhiyu Zhou, Hongfei Liu, Honglei Zhang, Yan Ding, Yong Cui and Hongguang NieBackground: Airway epithelium plays an essential role in maintaining the homeostasis and function of respiratory system as the first line of host defense. Of note, epithelial sodium channel (ENaC) is one of the victims of LPS-induced airway injury. Regarding the great promise held by mesenchymal stem cells (MSCs) for regenerative medicine in the field of airway injury and the limitations of cell-based MSCs therapy, w Read More
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Survival of Beneficial Vaginal Lactobacilli (BVL) to Different Gastrointestinal Tract Conditions
Authors: Antonella Marchesi, Jessica A. Silva, Birgitt Wiese and María E.F. Nader-MacíasBackground: Lactobacilli are the dominant bacteria in the healthy vaginal tract, preventing the income of pathogenic microorganisms, either sexually or not transmitted. Probiotics are used to restore the vaginal microbiome by local administration. However, the ascendant colonization is proposed as a way to restore the vaginal balance, and to exert some complementary effects on the host, situation that requires that pro Read More
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Decoding Psoriasis: Integrated Bioinformatics Approach to Understand Hub Genes and Involved Pathways
Authors: Saumya Choudhary, Dibyabhaba Pradhan, Noor S. Khan, Harpreet Singh, George Thomas and Arun K. JainBackground: Psoriasis is a chronic immune mediated skin disorder with global prevalence of 0.2- 11.4%. Despite rare mortality, the severity of the disease could be understood by the accompanying comorbidities, that has even led to psychological problems among several patients. The cause and the disease mechanism still remain elusive. Objective: To identify potential therapeutic targets and affecting pathways for better insi Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
- Issue 46
- Issue 45
- Issue 44
- Issue 43
- Issue 42
- Issue 41
- Issue 40
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- Issue 31
- Issue 30
- Issue 29
- Issue 28
- Issue 27
- Issue 26
- Issue 25
- Issue 24
- Issue 23
- Issue 22
- Issue 21
- Issue 20
- Issue 19
- Issue 18
- Issue 17
- Issue 16
- Issue 15
- Issue 14
- Issue 13
- Issue 12
- Issue 11
- Issue 10
- Issue 9
- Issue 8
- Issue 7
- Issue 6
- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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