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- Volume 26, Issue 2, 2020
Current Pharmaceutical Design - Volume 26, Issue 2, 2020
Volume 26, Issue 2, 2020
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Specificity and Continuity of Schizophrenia and Bipolar Disorder: Relation to Biomarkers
Authors: Yuji Yamada, Madoka Matsumoto, Kazuki Iijima and Tomiki SumiyoshiSchizophrenia and bipolar disorder overlap considerably in terms of symptoms, familial patterns, risk genes, outcome, and treatment response. This article provides an overview of the specificity and continuity of schizophrenia and mood disorders on the basis of biomarkers, such as genes, molecules, cells, circuits, physiology and clinical phenomenology. Overall, the discussions herein provided support for the view that schiz Read More
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The Potential Role of Functional Near-Infrared Spectroscopy as Clinical Biomarkers in Schizophrenia
Authors: Po-Han Chou, Chun-Jun Huang and Chia-Wei SunFunctional near-infrared spectroscopy (fNIRS) is a recently developed technique that can measure hemoglobin changes in the cerebral cortex, and fNIRS-based research in psychiatry has been progressing rapidly. fNIRS is advantageous in its noninvasiveness, ease of administration, tolerance of small movements, inexpensiveness, strong signal correlations with fMRI signals, and in providing imaging with excellent time resolution Read More
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Augmentation Strategies for Clozapine-Resistant Patients with Schizophrenia
Authors: Yi-Hang Chiu, Chia-Yueh Hsu, Mong-Liang Lu and Chun-Hsin ChenBackground: Clozapine has been used in treatment-resistant patients with schizophrenia. However, only 40% of patients with treatment-resistant schizophrenia have response to clozapine. Many augmentation strategies have been proposed to treat those clozapine-resistant patients, but the results are inconclusive. In this review, we intended to review papers dealing with the augmentation strategies in the treatment of cloza Read More
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Survey of NMDA Receptor-related Biomarkers for Depression
Authors: Yu-Ming Chen, Chieh-Hsin Lin and Hsien-Yuan LaneMajor depressive disorder (MDD) is an important cause of disability in the world. Depression has negative influences on a person’s mental and physical health, quality of life, and functioning. The pathophysiology of depression has not yet been confirmed. The traditional monoamine hypothesis of MDD could not explain the unsatisfactory treatment response of antidepressants. Thus, it is necessary to search other pro Read More
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Inflammatory Biomarkers for Mood Disorders - A Brief Narrative Review
Authors: Hui H. Chang and Po S. ChenBackground: The nervous system and the immune system interact consistently in the brain and peripheries. Inflammation in the brain not only alters the metabolism of neurotransmitters, but also causes network dysfunction, structural changes, and the development of mood symptomology in patients with mood disorders. In addition, the dysregulation of the neuroimmune axis in mood disorders drives multiple-system comor Read More
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Therapeutic Strategies for Treatment-resistant Depression: State of the Art and Future Perspectives
Authors: Kah K. Goh, Shen-Chieh Chang, Chun-Hsin Chen and Mong-Liang LuIn this narrative review, we intended to summarize the evidence of pharmacological and somatic treatment choices for treatment-resistant depression (TRD). There are several types of therapeutic strategies to improve inadequate response to antidepressant treatment. The first step for patients with TRD is to optimize the dosage and duration of antidepressants as well as to ensure their drug compliance. The shift to anti Read More
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Adhesion Molecules as Potential Novel Biomarkers for Opioid Dependence
Authors: Yu-Li Liu, Hsiang-Wei Kuo, Chiu-Ping Fang, Jieh-Hen Tsung and Andrew C.H. ChenBackground: Cell-cell adhesion is essential in maintaining the structure and function of an organ. Several adhesion molecules have recently been identified as associated with heroin dependence in both genetic and peripheral plasma studies. Methods and Results: We reviewed literature concerning studies on adhesion molecules in opioid addictions in rodents and human, including human genetic associations in different e Read More
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A Single Medical Marker for Diagnosis of Methamphetamine Addiction - DNA Methylation of SHATI/NAT8L Promoter Sites from Patient Blood
Background: Methamphetamine (METH) is one of the most widely distributed psychostimulants worldwide. Despite active counter measures taken by different countries, neither overall usage of METH nor the frequency of repeat users has reduced over the past decade. METH induces abuse and dependence as it acts on the central nervous system and temporarily stimulates the brain. The recidivism rate for abuse of stimula Read More
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Anti-angiogenesis Potential of Phytochemicals for the Therapeutic Management of Tumors
The role of angiogeneses during the growth and progression of tumors is well documented. Likewise, a balance is generally maintained between the cellular proliferation and the apoptosis, therefore, the tumors can persist for years in a dormant phase. During the past few years, many hypotheses have been proposed relating to the importance of tumor angiogenesis for the development and spread of tumors and preve Read More
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Nanoemulgel: A Promising Phase in Drug Delivery
Authors: Gururaj C. Aithal, Reema Narayan and Usha Y. NayakRecently, the delivery of hydrophobic/ poorly water-soluble drugs has been a challenging task. Various strategies have been developed to counter the former along with other prime issues, such as stability, bioavailability etc. However, only few formulations have been successful in addressing the problems and nanoemulgel is a standout among them. Nanoemulgels are appropriate candidates for drug delivery because of their Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
- Issue 46
- Issue 45
- Issue 44
- Issue 43
- Issue 42
- Issue 41
- Issue 40
- Issue 39
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- Issue 32
- Issue 31
- Issue 30
- Issue 29
- Issue 28
- Issue 27
- Issue 26
- Issue 25
- Issue 24
- Issue 23
- Issue 22
- Issue 21
- Issue 20
- Issue 19
- Issue 18
- Issue 17
- Issue 16
- Issue 15
- Issue 14
- Issue 13
- Issue 12
- Issue 11
- Issue 10
- Issue 9
- Issue 8
- Issue 7
- Issue 6
- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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