Current Organic Chemistry - Volume 5, Issue 10, 2001

The characteristic features of 13C solid state NMR applications are discussed. The spectra are routinely measured with cross-polarisation (CP) pulse sequence and fast spinning under magic angle (MAS). Additional techniques (dipolar dephase, variation of cross-polarisation contact time) influence the signal intensities and enable selective observation of nonprotonated or protonated carbons. Solid state NMR is complementary to X-r Read More

Most recent research works on the hydrogen-bonded structure of solid 17O-labeled peptides and polypeptides by means of solid -state 17O NMR are presented. It has been demonstrated that 17O-labeling andsolid -state 17O NMR provide useful informations about the hydrogen-bonded structure between the amide oxygen and proton of peptides and polypeptides in the solid state, in addition to 1H, 13C and 15N techniques.

In situ MAS NMR has been demonstrated to be a superior technique for analyzing desorbed reactants, reacting adsorbates, intermediates and products. The results are useful for getting deeper insights into catalytic processes and reaction kinetics, and for re vealing the mechanisms of organic reactions. The utility of in situ NMR spectroscopy has demonstrated that this technique is an important means for the studies of Read More

Nuclear magnetic resonance (NMR) has become established as a powerful tool for qualitative and semi-quantitative analysis of complex mixtures of body fluids, intact cells, tissues and their extracts. Such studies are finding increasing applications in clinical and medical sciences. 1H and 31P NMR provide a noninvasive probe of high-energy compounds, amino acids, and compounds of phospholipid metabolism in cells and tissues. 1 Read More

The small-sized cyclic imides and amides have been for a long time known as convenient models for study of numerous biochemical processes. In addition, owing to the structural resemblance with their naturally occurring analogues, biological activity has been documented for a number of these compounds. Recent development of the experimental and especially high-level theoretical structural methods has provided new e Read More