¹⁷O-Isotope Labeling and Hydrogen-Bonded Structure Investigation in Peptides and Polypeptides by Solid State ¹⁷O NMR

Most recent research works on the hydrogen-bonded structure of solid ¹⁷O-labeled peptides and polypeptides by means of solid -state 17O NMR are presented. It has been demonstrated that ¹⁷O-labeling andsolid -state ¹⁷O NMR provide useful informations about the hydrogen-bonded structure between the amide oxygen and proton of peptides and polypeptides in the solid state, in addition to ¹H, ¹³C and ¹⁵N techniques.