Current Organic Chemistry - Volume 5, Issue 4, 2001

In this review we have sought to give the reader an appreciation of the many synthetic applications now known for the more popular asymmetric (3,3)sigmatropic rearrangements. The ability to predict the stereochemical outcome of the rearrangements, and the ability to prepare products containing several contiguous chiral centres makes the application of such asymmetric rearrangements an attractive proposition to the Read More

The beeta-turn is a common recognition feature between peptide ligands and their macromolecular targets. The cyclization of a short peptide segment with a linker is one method of imitating this conformation. The first part of this review discusses tethering strategies which have resulted in the development of mimetics for the enkephalins and somatostatin as well as in the discovery of antagonists for targets such as thrombi Read More

Filamentous fungi are capable of catalyzing regio- and stereoselective hydroxylation on an extensive array of natural and synthetic hydrophobic organic substrates. A significant benefit of fungal hydroxylation is that non-activated carbon centers can be functionalized in ways that may not be easily emulated by classical organic means. The enzymes thought to perform the hydroxylations are cytochrome P450 monooxygenase Read More