Current Organic Chemistry - Volume 5, Issue 12, 2001

This work reviews the synthesis of a class of stable sugar mimics termed, C-saccharides. These compounds are stable analogs of the corresponding O-saccharides in which the interglycosidic oxygen has been replaced by a carbon atom. For the most part, this review focuses on the synthesis of C-disaccharides. The organization is based on the type of chemistry used to assemble the target and has the following sub-sections: sig Read More

The field of glycobiology has recently enjoyed an enormous expansion boosted by new discoveries of the critical functions that carbohydrates play in nature. Further research in this area and the entry of carbohydrates into the medical and pharmaceutical fields will undoubtedly require easy access to these molecules. Recombinant glycosidases and glycosyltransferases, as well as their mutants and fusion proteins have alread Read More

As other monosaccharide mimics such as the azasugars and the carbasugars (with nitrogen and carbon atom, respectively, instead of oxygen atom in the ring) the thiosugars (with sulfur atom instead of oxygen atom in the ring) have gained importance in glycobiology and as potential drugs. Biological properties of monothiosaccharides are presented and the methods for their synthesis are reviewed and analyzed. Since the r Read More