Current Organic Chemistry - Volume 5, Issue 11, 2001

Biological systems use the interplay of redox and molecular recognition to regulate a wide variety of processes and transformations. In our research, we use synthetic model systems to gain a better understanding of the role of non-covalent interactions in controlling cofactor function. Conversely, redox events can be used to control recognition processes, providing a useful direction for the creation of molecular devices

The application of stabilized metal carbenes as reactive intermediates in synthesis has greatly expanded because of the wide array of structures that are available from these reactions. In order to expand the usefulness of these reactions, several investigators have focused on the development of chiral catalysts that cab effect asymmetric carbene reactions. This review will cover the development and application of Read More

Over the past several years, much research has centered on the development of small molecules that, through multivalent binding interactions, enhance the regulation of fundamental biological functions. The design of a wide range of potential therapeutics focuses on mimicking natural systems that control the biological effect of protein-ligand interactions through multivalency. In this review, the various approaches to ac Read More