Current Organic Chemistry - Volume 5, Issue 1, 2001

Peptides are essentially small version of proteins and the structure of peptides is best described as a chain of amino acids linked to each other through amide bonds. In the chemical synthesis of peptides, two procedures are primarily used, although they are both based on fundamentally same principles one is a solution method and the other being a solid-phase method carried out on a resin. The chemistry of peptide synt Read More

This review describes current methods for peptide and protein syntheses, largely from a strategic point of view. The solid phase method is useful for the rapid preparation of peptides. Two major synthetic strategies have been adopted by this method, namely, the Boc and Fmoc strategies. At the final stage of the Boc solid phase method, a protected peptide resin is treated with a strong acid to obtain a free peptide. On the oth Read More

Short chain dehydrogenases/reductases (SDR) constitute a large protein family. The SDR family now includes more than 1,000 enzymes from humans, mammals, insects and bacteria, and exhibits a wide variety of substrate specificity for steroids, retinoids, prostaglandins, sugars, alcohols and other small molecules. These enzymes have a residue identity level of 15-30 perent. Much has been done in the last decade to unde Read More