Current Organic Chemistry - Volume 28, Issue 18, 2024

Nowadays palladium-catalyzed C-H bond activation is a useful approach for the synthetic transformation of organic compounds due to step economy, the use of non-prefunctionalized substrates and reduced chemical wastes. Among the various synthetic strategies, palladium catalyzed intra and inter-molecular C-H bond activation has recently drawn a lot of interest to synthesize the decorated π-conjugated polycyclic ar Read More

Nitrogen-positioned radicals are chemical entities that have a lengthier history than carbon ones and their high reactivity makes them invaluable. But, despite its power, much of its chemistry is still uncharted. Currently, developed methodologies to access nitrogen-positioned radicals, such as transition metal catalysis or visible-light photoredox methods through a single-electron transfer process, avoiding the use of harmful or t Read More

Bioactive glass (BG) shows great potential as a biomaterial for bone regeneration. Chitosan enhances the biological characteristics of BG. Chitosan is the sole commonly utilized natural polysaccharide that may be chemically altered for various purposes and roles. Composite materials formed by combining chitosan bioactive glass (BG) nanoparticles and microparticles are used in this context. Integrating bioactive glasses enhance Read More

Nonsteroidal anti-inflammatory drugs account for a sizeable fraction of the drugs prescribed worldwide. If consumed for a long time, they can cause ulcers and lifethreatening side effects. Since the acidic group present in NSAIDs is mainly responsible for these side effects, the scientists try to synthesize polymer drug conjugates that avoid these side effects but still retain the potency of the parent drug. Macromolecular drug Read More

In this study, a series of novel pyrazole-based compounds were synthesized starting from the precursor ethyl 3-(4-amino-1-phenyl-3-((4-sulfamoylphenyl)carbamoyl)-1Hpyrazol- 5-yl)-3-oxopropanoate (2). Various synthetic routes were used to obtain pyrazolylpyrazolone 3, tricyclic dipyrazolopyridine 4a-c, thiazolyl-bipyrazoles 5 & 6, pyrazolo[4,3- b]pyridines 7 & 9, and tricyclic pyranopyrazolopyridine 10a-c. These co Read More