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- Volume 28, Issue 16, 2024
Current Organic Chemistry - Volume 28, Issue 16, 2024
Volume 28, Issue 16, 2024
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s The Intra- and Intermolecular Friedel-Crafts Acylation of Amino Acid Derivatives in Stereo-retarded Manner
Authors: Zetryana P. Tachrim and Makoto HashimotoThe Friedel-Crafts acylation of natural or unnatural amino acids in stereoretarded manner is willing to prescribed here. Depending on its main skeleton, the typical intra- and intermolecular Friedel-Crafts reaction of amino acids can be differentiated. The unique amino acid's general structure can contribute to the reaction between its carboxyl group and the side chain. Depending on the Friedel-Crafts reaction conditio Read More
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Recent Advances in Trifluoromethylation of Olefins, Aldehydes, and Ketones
Authors: Mengran Bai, Liyuan Zhang, Lu Liu, Chenyu Jia, Yuting Zheng, Huijian Shang, Hui Sun and Bin CuiDue to the robust electrophilic properties of the trifluoromethyl group (-CF3), its incorporation into organic compounds can markedly alter their ester affinity, stability, bioavailability, and other properties. The trifluoromethylation reaction is currently experiencing rapid advancement, with an expanding array of substrates and the emergence of novel methodologies. Consequently, compounds containing the -CF3 moiety find e Read More
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Developments of Pyrrolo[2,3-d]pyrimidines with Pharmaceutical Potential
Authors: Aymn E. Rashad, Tamer El Malah and Ahmed H. ShamroukhIn terms of fused heterocyclic compounds, pyrrolopyrimidines, and their substituted analogs are among the most extensively explored scaffolds. Based on the location of the nitrogen atom in the pyrrole ring, pyrrolopyrimidines have different isomers. This study deals only with the pyrrolo[2,3-d]pyrimidine isomer. Several techniques are represented and discussed in this review for producing pyrrolo[2,3-d]pyrimidine derivatives. Read More
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Three Diterpene Lactones from Andrographis paniculata (Burm. f) Nees In vitro, In silico Assessment of the Anticancer and Novel Liposomal Encapsulation Efficiency
Authors: Tran L. Thi Thanh, Trinh Thi Diep, Nguyen Thi To Uyen, Tran Nguyen Minh An and Le Van TanThree compounds from Andrographis paniculata (Burm. f) Nees leaf were isolated and identified using 1H, 13C, 2D-NMR, and HR-MS techniques for the first time. Compound 3,19-Di-O-acetylandrographolide (3,19-DAA) or (4) is produced by acetylating compound (2). Compounds (2) and (4) have been investigated for their cytotoxic effects on three human cancer cell lines (SK-LU-1, Hela, and HepG2) using the MTT method. Compo Read More
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Development of New N- and S-substituted-imidazolidin-4-one Analogues with Potent Anti-breast Cancer Activity: In vitro Molecular Docking Assessment
2-Thioxoimidazolidin-4-one derivatives 3, 4, 7, 8, and 9 have been synthesized from 3- (benzylideneamino)-2-thioxoimidazolidin-4-one (2) as a starting material. Compounds 3, 4, 7, 8, and 9 were obtained via the reaction of compound (2) with ethyl chloroacetate, methyl acrylate, and chlorophenacyl bromide, respectively. Elemental analysis and several spectroscopy techniques were used to confirm the synthesized co Read More
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Functionalized Adenine-based Receptors for Monocarboxylic Acids' Recognition
Authors: Tanushree Sen, Suman Adhikari, Nabajyoti Baildya and Kumaresh GhoshThree receptors 1-3, built on adenine, have been synthesized, structurally characterized, and successfully employed for the recognition of monocarboxylic acids. The adenine- based receptors 1-3 have been found to bind monocarboxylic acids via the Hoogsteen (HG) binding site or the Watson-Crick (WC) binding site and form 1:1 complexes in CHCl3. Detailed binding of the receptors 1-3, in the presence of the monocar Read More
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The Synthesis of Trans-enediones from Furan Derivatives using Pyridinium Chlorochromate: An Explanation
Authors: Maurizio D'Auria and Fausto LangerameThe reaction of pyridinium chlorochromate (PCC) with furan derivatives gives the corresponding enediones. However, the reaction of pyridinium chlorochromate with furan to give enedione derivatives cannot be performed by using commercial PCC. XRD and XPS analysis of the reagents coupled with DFT calculations can allow us to explain this different behavior. Homemade and commercial PCC have different colors and Read More
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Volumes & issues
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Volume 29 (2025)
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Volume 28 (2024)
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Volume 27 (2023)
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Volume 26 (2022)
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Volume 25 (2021)
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Volume 24 (2020)
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Volume 23 (2019)
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Volume 22 (2018)
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Volume 21 (2017)
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Volume 20 (2016)
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Volume 19 (2015)
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Volume 18 (2014)
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Volume 17 (2013)
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Volume 16 (2012)
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Volume 15 (2011)
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Volume 14 (2010)
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Volume 13 (2009)
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Volume 12 (2008)
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Volume 11 (2007)
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Volume 10 (2006)
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Volume 9 (2005)
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Volume 8 (2004)
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Volume 7 (2003)
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Volume 6 (2002)
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Volume 5 (2001)
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Volume 4 (2000)
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