Current Organic Chemistry - Volume 28, Issue 3, 2024

Tetrahydroquinoxalines are found in many biologically and pharmacologically active small molecules. In the past two decades, significant progress has been made in the development of novel synthetic routes for the preparation of biologically active tetrahydroquinoxalines and their derivatives. This synthetic review aims to provide a comprehensive overview of the advancements in the field of various synthetic strategies and me Read More

Inflammation is an intricate physiological reaction that has a vital function in the body's protection against detrimental stimuli. Nevertheless, uncontrolled inflammation may result in the development of long-term conditions, such as arthritis, cardiovascular disorders, and even cancer. Scientists are always searching for new medicinal substances that might efficiently regulate the inflammatory response. Due to its distin Read More

Quinolones are among the class of antibiotics that are used most frequently worldwide and are used for treating a variety of bacterial diseases in humans. Recent research has shown that new, improved analogues of quinolones are being used as anticancer, antifungal, antiviral and other antimicrobial agents. In an earlier review (Part 1), we discussed the synthesis and antibacterial activity of quinolones in detail. This revie Read More

Synthetic organic molecules are vital for human life, serving as medications, pesticides, dyes, and food additives. Organic synthesis provides routes for the production of these molecules. The traditional methods of organic synthesis require energy, solvents, time, and certain conditions based on the nature of the reactions. To address the issues associated with conventional processes, various environmentally friendly (green) meth Read More

1,2-Dimethyl-3-methylsulfanylbenzene is the key intermediate of topramezone. This work designed a two-step continuous-flow device to synthesize 1,2-dimethyl-3- methylsulfanylbenzene via diazotization and methanethiolation. The results showed that compared with the batch process, the continuous-flow method greatly shortened the residence time to 1 minute, avoided the accumulation of large amounts of diazonium salt Read More

In this study, some new pyrazoline derivatives bearing cyano or nitro groups were synthesized. The structures of the compounds were characterized by IR, 1H-NMR, 13C-NMR and elemental analysis data. The ABTS·+, DPPH·, CUPRAC and β-Carotene/linoleic acid assays were carried out to determine the antioxidant activity of the synthesized pyrazolines. Compound P14 showed higher antioxidant activity than the stan Read More