Current Organic Chemistry - Volume 23, Issue 18, 2019

Amines are important and valuable intermediates in the pharmaceutical, plastic and agrochemical industry. Hence, there is an increasing interest in developing improved process for the synthesis of amines. The heterogeneous catalytic hydrogenation of nitriles is one of the most frequently applied methods for the synthesis of diverse amines, but the homogeneous catalysis has also received a growing attention from the cat Read More

The field of heterocyclic chemistry has been revolutionized using transition metal catalysts in recent years. Various research groups have focused on the development of general protocols to achieve better functional group compatibilities and greater levels of molecular complexity under mild reaction conditions, using easily available starting substrates. The methodologies used earlier for their synthesis were less approachable Read More

Arylglyoxals are important synthons that have been used in the construction of a diverse spectrum of compounds. The use of multicomponent approaches in organic synthesis due to its environmentally friendly nature is a step forward towards sustainability. This review will offer the reader insightful perspectives on the use of arylglyoxals for the synthesis of various heterocyclic compounds like pyrroles, pyrazoles, furans, imi Read More

A new method for the preparation of three new curcumin analogues is described by the connection of pentadienones to carbohydrate units. From L-Rhamnose and D-Galactose, several functionalization reactions were performed to obtain the desired sugar units. The sugars 8, 18 and 19, after obtained, were used as starting material for the association with curcumin-derived pentadienones, thus giving rise to three new chalcon Read More

In this study, the synthesis and evaluation of norfloxacin analogues of dimethyl citrate conjugates were described and their antibacterial and anticancer activities were assessed. The cognate 7-substituted norfloxacin citrate conjugates are active against various strains of bacteria, including MRSA (methicillin-resistant Staphylococcus aureus) with higher activity than ciprofloxacin. Screening results indicated that com Read More