Current Organic Chemistry - Volume 23, Issue 19, 2019

This review summarizes the data published on the methods of preparation of β- keto amides as a versatile synthon for many heterocyclic rings and asymmetric urea derivatives. Based on the starting materials used for the synthesis of β-keto amides, eight methods were reported including β-keto acids and their derivatives, Meldrum’s acid and their derivatives, diketene, 2,6-dimethyl-1,3-dioxin-4-one derivatives (TMD), α-diazo Read More

In recent years, the synthesis and evaluation of the biological properties of 1,2,4,5-tetrasubstituted-1H-imidazole derivatives have been the subject of a large number of studies by academia and industry. In these studies it has been shown that this large and highly differentiated class of heteroarene derivatives includes high valuable compounds having important biological and pharmacological properties such as antibact Read More

O-Acylated 2,2,6,6-tetramethylpiperidine-N-oxyls (abbr. O-AcylTEMPOs) are easily available and stable carboxylic derivatives, but their utility in organic synthesis is unexplored in contrast to analogues, such as the N-methoxy-N-methylamides, known as Weinreb amides. Especially, the O–N unit of the O-acylTEMPOs dictates a fairly electronwithdrawing character for the carbonyl function. This enhances the reactivity and stab Read More

Currently, peptide nucleic acids (PNAs) play an important role as therapeuticAhmed S. Abdelbaky1,2,*, Ivan A. Prokhorov1, Elena V. Gnuskova1, Olga V. Esipova1 and Yulia G. Kirillova1 agents, molecular tools for diagnosis and detection of genetic diseases as well as in biosensor probes. This research aims to optimize the synthesis of aeg- and γ-(S)-Me PNA monomers based on L-Ala, intended for oligomerization according to t Read More

Triterpenes and phytosterols are classes of natural compounds widespread in plants possessing a great number of pharmacological activities. In our continued search for new compounds from natural sources with pharmacological potential, we prepared a series of novel stigmasterol and ursolic acid (UA) derivatives by coupling with L-proline, L-cysteine and L-glutamic acid. Unlike stigmasterol, the eight derivatives obtaine Read More

Due to an overlook the reference nos. 1, 6, 8, 15, 16, 34, 40, 41, 46, 47, 48, 68, 74, 80, 81 & 96 were published erroneously in the article, entitled: “Newer Developments in the Synthesis of P-Heterocycles” in “Current Organic Chemistry”, 2019, Vol. 23, No. 12, pp. 1342- 1355.”